A Case of Reverse Amblyopia of the Dominant Eye that was Refractory to Treatment

PURPOSE: The treatment for reverse amblyopia is to discontinue occlusion therapy with most cases showing improvement of visual acuity in the dominant eye. Herein, we report a case of reverse amblyopia after monocular cataract surgery which was refractory to treatment and showed strabismus. CASE SUMMARY: A 3-month-old female was diagnosed with congenital cataract in her left eye and underwent aspiration of lenses, posterior capsulectomy, and anterior vitrectomy. After the surgery, her mother performed strict 6:1 occlusion therapy on her right eye as prescribed. The best corrected visual acuity measured for the first time at the age of 32 months was 1.70 in the right eye and 0.52 in the left eye and the patient was referred to the Pediatric Ophthalmology clinic. At that time, eccentric fixation with slight exotropia was observed. With the diagnosis of reverse amblyopia in the right eye, the occlusion therapy was postponed for several months, however, visual acuity in the right eye did not recover after 4 months. After the age of 3 years, she was treated with left eye occlusion therapy, but the vision was still low and eccentric fixation was observed. At the age of 5 years she was continuously treated with left eye occlusion and the eccentric fixation improved, and at 6 years of age, a secondary intraocular lens implantation was performed. At 9 years of age, the patient underwent lateral rectus recession and medial rectus resection in the right eye for the treatment of exotropia. CONCLUSIONS: In the case of monocular congenital cataract, occlusion therapy should be prescribed after surgical treatment. However, because reverse amblyopia which is refractory to treatment can occur, the fixation pattern should be monitored carefully and the occlusion duration controlled appropriately.

Occlusion-amblyopia following high dose oral levodopa combined with part time patching.

Part time occlusion therapy is not reported to cause occlusion (reverse) amblyopia. However, when combined with high dose oral levodopa, an increase in the plasticity of the visual cortex can lead to occlusion amblyopia. In this case report, we describe a six year old child who developed occlusion amblyopia following part time patching combined with oral levodopa.