RESUMEN
Rooibos, Aspalathus linearis (Barm.f.) R. Dahlgren, is a South African endemic plant. Modern researches have shown that its leaves and branches are rich in polyphenols and specific flavonoids, aspalathin and nothofagin, which have many pharmacological effects on improving oxidative stress and inflammation, reducing blood sugar, protecting liver, resisting cancer and mutagenesis. In this paper, the research progress of Rooibos is summarized which could provide reference for further research and development.
RESUMEN
OBJECTIVE@#To investigate the role of red palm oil (RPO), rooibos tea extract (RTE) and their combined treatment (RPO + RTE) on antioxidant status in streptozotocin (STZ)-induced diabetic rats.@*METHODS@#Diabetes mellitus was induced by a single administration of streptozotocin (50 mg/kg) and the rats were treated for 7 weeks. Antioxidant enzymes [catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD)], antioxidant capacity [trolox equivalence antioxidant capacity (TEAC), oxygen radical absorbance capacity (ORAC)] as well as total protein, albumin, globulin, total glutathione, conjugated diene and thiobarbituric acid reactive substances (TBARS) were investigated.@*RESULTS@#Treatment with RPO, RTE and RPO + RTE significantly (p>0.05) improved liver SOD and plasma ORAC in the diabetic rats. Similarly, diabetic rats treated with RTE and RPO + RTE enhanced liver GPx. A significant (P<0.05) increase in the plasma TBARS in the diabetic control group was observed when compared with the normal control group. Treatment of diabetic rats with RTE and RPO + RTE reduced plasma TBARS to a level not significantly different at P<0.05 from the normal control group.@*CONCLUSIONS@#The results revealed the anti-oxidative potentials of red palm oil, rooibos and their combination in diabetic conditions and hence, they could be useful in the management of diabetes and its complications.
Asunto(s)
Animales , Masculino , Ratas , Antioxidantes , Química , Farmacología , Aspalathus , Química , Proteínas Sanguíneas , Peso Corporal , Diabetes Mellitus Experimental , Metabolismo , Glutatión , Hígado , Química , Tamaño de los Órganos , Estrés Oxidativo , Oxidorreductasas , Sangre , Aceite de Palma , Extractos Vegetales , Química , Farmacología , Aceites de Plantas , Química , Farmacología , Polifenoles , Química , Ratas WistarRESUMEN
PURPOSE: To evaluate the therapeutic potential of green tea to treat renal stone, we examined the effect of green tea on the formation and the excretion of experimentally induced calcium oxalate (CaOx) stones in rat kidneys. MATERIALS AND METHODS: CaOx nephrolithiasis was induced by administering 1% ethylene glycol (EG) for 4 weeks. To investigate the effect of tea on the formation CaOx stones, the rats were simultaneously administered either 0.2% green tea or 0.5% rooibos tea. To verify the action of green tea on the excretion of CaOx stones, the rats were divided into four groups after the administration of 1% EG water for 4 weeks and then fed with either 0.2% green tea, 0.5% rooibos tea or 80mg/l furosemide-containing 1% EG water for 4 weeks. The right kidney was frozen for mRNA measurements, with the left fixed for counting crystal deposits. Twenty-four hour urine volume and urinary excretions of oxalate, uric acid, calcium and magnesium were measured. RESULTS: Urinary biochemistry and 24 hour urine output were apparently unchanged by taking either the green tea or rooibos tea. The increases of CaOx crystal deposits and osteopontin mRNA expressions in the kidneys by the administration of 1% EG water were markedly decreased by both tea intakes, while there were no significant differences in the mRNA levels of CuZn- and Mn-superoxide dismutases between the groups. CONCLUSIONS: Green and rooibos teas significantly attenuated the calcium crystal depositions in the kidneys. Down-regulations of the osteopontin mRNA levels may be involved in the inhibitory effects of the teas on the renal CaOx stone formation.