RESUMEN
Objective To evaluate the clinical safety and therapeutic efficacy of Rupiling Granules in treating cyclomastopathy (classified into deficiency of liver and kidney,disharmony of thoroughfare and Ren channels or complicated with syndrome of qi stagnation,blood stasis,or phlegm blended with blood stasis). Methods A randomized,double-blinded,positive drug controlled parallel polycentric trial was carried out. Results Rupiling Granules showed good therapeutic effect on reducing lump in breast,relieving pain of breast,improving TCM symptoms scoring. Conclusion Rupiling Granules is safe and effective for the treatment of cyclomastopathy (deficiency of liver and kidney ,disharmony of thoroughfare and Ren channels or complicated with syndrome of qi stagnation,blood stasis,or phlegm blended with blood stasis)