Pedunculated Sclerotic Fibroma Resembling Soft Fibroma / 대한피부과학회지

Sclerotic fibroma is a rare skin neoplasm that can occur seen sporadically or in association with Cowden's disease. Clinically, it presents as asymptomatic flesh-colored or pinkish slow-growing papules or nodules with a wide anatomical distribution. We report a rare case of pedunculated type of sclerotic fibroma resembling soft fibroma, which has not been reported in Korea.

Cowden Syndrome Accompanied by Multiple Sclerotic Fibroma on the Face / 대한피부과학회지

Cowden syndrome (CS) is a rare genodermatosis that is characterized by multiple hamartomatous tumors of an ectodermal, mesodermal and endodermal origin. CS is associated with an increased risk of malignancy and especially breast cancer, thyroid cancer, uterine cancer and renal cell carcinoma. The characteristic features of the disease are mucocutaneous findings, including multiple facial trichilemmomas, oral mucosal papillomatosis and acral keratoses. Multiple sclerotic fibroma is also known to be a clue to diagnose CS. We herein emphasize that multiple sclerotic fibromas of the skin are an important marker of CS, which may also be helpful for making an early diagnosis.

A Case of Sclerotic Fibroma / 대한피부과학회지

Sclerotic fibroma of the skin is an uncommon benign tumor characterized histopathologically by a well-circumscribed dermal nodule showing hypocellular hyalinized collagen bundles. The bundles are separated by clefts and arranged in a storiform pattern. The histogenesis of this fibroma is uncertain. Herein, we report a case of sclerotic fibroma presenting on the left ala nasi of a 27-year-old woman without Cowden's disease.

A Case of Neurotized Nevus with Sclerotic Fibroma-like Change / 대한피부과학회지

We report a case of neurotized nevus with a sclerotic fibroma-like change in a 60-year-old female patient, who presented with a brown colored pedunculated nodule on the upper quadrant of the abdomen. The skin biopsy revealed a well-circumscribed, non-encapsulated nodule in the reticular dermis, which consisted of hypocellular hyalinized collagen bundles separated by clefts mixed with nevus cells. Nevus cells are small with a spindle appearance and contain Meissner corpuscle-like structures called nevic corpuscles. We suggest that a sclerotic fibroma-like change is an evolutionary end-point of a pre-existing lesion. This is supported further by the fact that neuroid change in the intradermal nevus represents the end stage of maturation of melanocytes of the nevi.

Comparison of Sporadic Sclerotic Fibroma and Solitary Fibrous Tumor in the Oral Cavity

Sporadic sclerotic fibroma (SF) and solitary fibrous tumor (SFT) arising in the oral cavity are very rare. In this report, we describe two cases of oral pathology, one involving SF and the other involving SFT. Both cases presented with well- circumscribed, firm nodules with similar gross findings. However, the histologic findings of the SF and SFT showed rather distinct features. The SF was composed of hyalinized sclerotic collagen bundles arranged in a whorled pattern, whereas the SFT was formed by spindles cells arranged in hypo- and hypercellular areas. The immunohistochemical findings were similar in both cases; there was positivity for vimentin, CD34, and CD99, but bcl-2 positivity was only seen in the SFT. Although their histopathologies are similar, SF and SFT should be considered in the differential diagnosis of soft tissue tumors in the oral cavity.

Two Cases of Dermatofibroma with Sclerotic Fibroma-like Change / 대한피부과학회지

Sclerotic fibroma is often regarded as a unique proliferating lesion, but some authors regard it as an end stage of other neoplasms, especially dermatofibroma. We report two cases of dermatofibroma with sclerotic fibroma-like change. The skin biopsy specimens from different patients showed a common finding of dermatofibroma, while some portions of the tumor were replaced by thick, hyalinized, eosinophilic collagen bundles and empty clefts with low cellularity, which was histologically similar to sclerotic fibroma. According to these findings, dermatofibroma with sclerotic fibroma-like change can be evidence of the possible pathogenesis of sclerotic fibroma.

A Case of Sclerotic Fibroma / 대한피부과학회지

Sclerotic fibroma is one of the histologic variants of soft fibroma. Clinically, it presents as a solitary skin-colored nodule, usually less than 1 cm in diameter in adults and has a wide anatomical distribution. Histologically, it is a well-circumscribed dermal nodule composed of hypocellular hyalinized collagen bundles separated by clefts and arranged in a storiform pattern. Treatment with simple excision is curative. We report a case of sclerotic fibroma in a 34-year-old man who presented an asymptomatic, bean-sized, intracutaneous nodule on his back for 3 years.

Two Cases of Sclerotic Fibroma / 대한피부과학회지

Sclerotic fibroma is an uncommom fibrotic neoplasm that can occur as solitary lesions in otherwise healthy individuals. Multiple sclerotic fibromas of the skin are considered a cutaneous marker of multiple hamartoma syndrome or Cowden's disease. Sclerotic fibroma was first described by Weary et al. in the tongue of a patient with Cowden's disease in 1972. Rapini and Golitz described the sporadic occurrence of histologically identical tumors, and they suggested the names `hypocellular fibroma' and `sclerotic fibromas of the skin' for these lesions in 1990. The characteristics of sclerotic fibromas include hypocellularity and stromal sclerosis with eosinophilic, hyalinized collagen bundles in a parallel or whorled arrangement. We report two cases of solitary sclerotic fibroma of the skin not associated with Cowden's disease.