RESUMEN
Objective: Through orthogonal test to find out the scientific conditions for dry-heat sterilization process of Scutellaria Baicalensis Radix powder. Methods: The microbial (bacterium and molds) quantity and the content of baicalin as the indexes, the temperature, time, thickness of powder as factors, the sterilization process for Scutellaria Baicalensis Radix powder was determined by L9(34) orthogonal test. Results: The optimal technological conditions for sterilization were 100°C, 10 h, and the powder thickness of 2 cm. Conclusion: This condition is proved by the amplified test and the large scale production, after the sterilization, the hygiene indexes of Scutellaria Baicalensis Radix powder can reach the requirements of Chinese Pharmacopoeia 2010. There is a good reproducibility but no significant difference for the content of baicalin before and after the sterilization.