Sebaceomas: a propósito de dos casos / Sebaceomas: report of two cases

Los sebaceomas son tumores infrecuentes que se originan en los anexos sebáceos. Suelen desarrollarse en adultos mayores, más frecuentemente en cabeza y cuello. Su denominación es controversial, presentando características histopatológicas y clínicas similares a otras entidades, que presentan diferenciación sebácea. El pronóstico de esta entidad es bueno, siendo su tratamiento la extirpación quirúrgica. Sin embargo, su relevancia clínica se establece por su asociación frecuente con el síndrome de Muir-Torre, por lo que ante la presencia de esta neoplasia, es necesario descartar neoplasias viscerales ocultas. Presentamos el caso de dos pacientes con sebaceomas en diferentes localizaciones, que hasta el momento de esta publicación no presentaron síndrome de Muir-Torre asociado y realizamos una revisión de la literatura.

Sebaceomas are infrequent tumors originated from the sebaceous annexes. They usually develop in the third decade, more frequently in the head and neck. Its denomination is controversial, presenting both histopathological and clinical characteristics similar to other entities, with sebaceous differentiation. The prognosis of the condition is good, being its treatment the surgical removal. Though, its clinical relevance is established by its frequent association with the Muir-Torre syndrome, so that, in the presence of this neoplasm, it is necessary to rule out occult visceral neoplasms. We present two cases of sebaceomas in different locations that until this moment did not present associated neoplasm.

A Case of Sebaceoma on the Right Earlobe / 대한피부과학회지

Sebaceoma, also known as sebaceous epithelioma, is a rare, benign, adnexal tumor with sebaceous differentiation. It usually appears as a yellowish papule, nodule, or plaque on the scalp and face, on which there are abundant sebaceous glands. Histologically, it is a well-circumscribed lesion composed of undifferentiated basaloid cells and mature sebaceous cells in relatively preserved lobulated architectures. A 31-year-old woman presented with a 1.3-cm ×1.1-cm nodule on the right earlobe. Mohs micrographic surgery was performed to completely remove it. Histopathological examination revealed that mature sebaceous cells with scalloped nuclei and focal cystic change were present in the lobule.

A Case of Eyelid Sebaceoma Mimicking Chalazion

PURPOSE: To report a rare case of sebaceoma misdiagnosed as chalazion. CASE SUMMARY: A 42-year-old female presented with a visible mass in her right lower eyelid. An elevated, hard mass was located at the margin of the right lower eyelid, and she had a history of incision and curettage under the clinical impression of chalazion. On eversion of the lower eyelid, the tarsal portion of the mass was visible as a white-yellowish lesion. The mass was excised under local anesthesia. A sebaceoma was diagnosed based on histopathological examinations. Immunohistochemical studies showed positive staining results for mutator L homologue 1 (MLH1), mutator S homologue 2 (MSH2), and mutator S homologue 6 (MSH6), and she had no past medical history or family history of internal malignancy, suggesting a low possibility of Muir-Torre syndrome. CONCLUSIONS: Eyelid sebaceoma should be considered as a differential diagnosis for refractory chalazion.

A Giant Sebaceous Epithelioma on the Scalp: A Case Report

PURPOSE: Sebaceous epithelioma (sebaceoma) is a benign tumor with sebaceous differentiation. It presents primarily as a yellowish papule or nodule on the face and scalp. It must be differentiated from basal cell carcinoma and other appendageal tumors. We report a giant sebaceous epithelioma on the scalp and describe the immunohistochemical character of the cells in sebaceous epithelioma to epithelial membrane antigen (EMA). METHODS: A 55-year-old-man who presented with 5-cm-diameter 2-cm-height, round shape exophytic ulcerated tumor on his head presented for treatment. The patient had noticed the lesion 40 years prior as a small yellowish plaque and 18 months ago, the plaque started to grow progressively larger. We excised the lesion with 1 cm resection margin, considering the possibility of malignancy because this lesion grossly resembled basal cell carcinoma (BCC). The defect was repaired with the use of a split-thickness skin graft. RESULTS: When we excised the lesion, the margin was clear. Histology showed nodules that consisted of an admixture of basaloid cells and mature adipocytes lacking an organized lobular architecture. Strong expression of EMA on mature adipose cells confirmed the differential diagnosis from BCC with sebaceous differentiation because of the absence of a nuclear palisade pattern and cleft-like spaces on the hematoxylin and eosin (H&E) section. CONCLUSION: We treated the giant sebaceous epithelioma on the scalp with surgical excision and a split-thickness skin graft. It is important to know that the diagnosis of sebaceous epithelioma should be made based on the histologic pattern of the H&E section. Immunohistochemistry with EMA can help to confirm the differential diagnosis between sebaceous epithelioma and BCC.

A Giant Sebaceous Epithelioma on the Scalp: A Case Report

PURPOSE: Sebaceous epithelioma (sebaceoma) is a benign tumor with sebaceous differentiation. It presents primarily as a yellowish papule or nodule on the face and scalp. It must be differentiated from basal cell carcinoma and other appendageal tumors. We report a giant sebaceous epithelioma on the scalp and describe the immunohistochemical character of the cells in sebaceous epithelioma to epithelial membrane antigen (EMA). METHODS: A 55-year-old-man who presented with 5-cm-diameter 2-cm-height, round shape exophytic ulcerated tumor on his head presented for treatment. The patient had noticed the lesion 40 years prior as a small yellowish plaque and 18 months ago, the plaque started to grow progressively larger. We excised the lesion with 1 cm resection margin, considering the possibility of malignancy because this lesion grossly resembled basal cell carcinoma (BCC). The defect was repaired with the use of a split-thickness skin graft. RESULTS: When we excised the lesion, the margin was clear. Histology showed nodules that consisted of an admixture of basaloid cells and mature adipocytes lacking an organized lobular architecture. Strong expression of EMA on mature adipose cells confirmed the differential diagnosis from BCC with sebaceous differentiation because of the absence of a nuclear palisade pattern and cleft-like spaces on the hematoxylin and eosin (H&E) section. CONCLUSION: We treated the giant sebaceous epithelioma on the scalp with surgical excision and a split-thickness skin graft. It is important to know that the diagnosis of sebaceous epithelioma should be made based on the histologic pattern of the H&E section. Immunohistochemistry with EMA can help to confirm the differential diagnosis between sebaceous epithelioma and BCC.

Muire-Torre syndrome: A case of sebaceous epithelioma with thyroid cancer / 대한내과학회지

Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis characterized by at least one rare sebaceous neoplasm occurring in association with at least one internal malignancy. The visceral neoplasms most frequently associated with MTS are colorectal and genitourinary cancer, accounting for approximately 50 and 25% of cases, respectively. MTS rarely occurs in association with head and neck cancers. We report a rare case of MTS involving follicular thyroid carcinoma in an 84-year-old female.

Muire-Torre syndrome: A case of sebaceous epithelioma with thyroid cancer / 대한내과학회지

Muir-Torre syndrome (MTS) is an autosomal dominant genodermatosis characterized by at least one rare sebaceous neoplasm occurring in association with at least one internal malignancy. The visceral neoplasms most frequently associated with MTS are colorectal and genitourinary cancer, accounting for approximately 50 and 25% of cases, respectively. MTS rarely occurs in association with head and neck cancers. We report a rare case of MTS involving follicular thyroid carcinoma in an 84-year-old female.

A Case of Nevus Sebaceus, Accompanied by Syringocystadenoma Papilliferum, a Basal Cell Carcinoma-like Tumor, Sebaceous Epithelioma, Apocrine Adenoma and Tumor of Follicular Infundibulum, with Repair by Subgaleal-periosteal Fixation / 대한피부과학회지

Nevus sebaceus is well-known for its potential to develop both benign and malignant neoplasms of epidermal and adnexal origin. We found 5 tumors including syringocystadenoma papilliferum, a basal cell carcinoma-like tumor, sebaceous epithelioma, a tumor of follicular infundibulum and apocrine adenoma within a single nevus sebaceus lesion in a 37-year-old man. This is a rarely reported case of a nevus sebaceus lesion containing a basal carcinoma-like, trichoblastoma-like skin tumor and tumors of follicular infundibulum. The lesion was treated by wide excision and repaired with subgaleal-periosteal fixation which resulted in good wound healing.

A Case of Sebaceous Epithelioma / 대한피부과학회지

Sebaceous epithelioma is a rare skin appendage tumor with sebaceous differentiation and appears as yellow papules, nodules, or plaques, most commonly in areas with large numbers of sebaceous glands, such as the face. Histopathologically, sebaceous epitheliomas are composed of circumscribed nodules consisting predominantly of basaloid cells and foci of sebaceous differentiation. We report a case of sebaceous epithelioma which appeared as a yellowish to erythematous patch on the forehead in a 55-year-old woman.

A Case of Sebaceous Epithelioma Arising from Nevus Sebaceus / 대한피부과학회지

Nevus sebaceus is a congenital cutaneous hamartoma which has a potential to develop both benign and malignant neoplasms in late life. One of the benign neoplasms is sebaceous epithelioma that is developed secondarily in lesions of nevus sebaceus. We have experienced a case of sebaceous epithelioma associated with nevus sebaceus in a 54-year-old male. Two nodular tumors developed on the verrucous surfaced yellowish plaque on the scalp. Histopathologic examination revealed mature sebaceous glands in the upper dermis and ectopic apocrine glands in the lower dermis on the verrucous surfaced yellowish plaque, and undifferentiated basaloid cells which were arranged in a palisading pattern at the periphery and groups of mature sebaceous cells on the two nodular tumors. We report a case of sebaceous epithelioma arising from nevus sebaceus.

A Case of Sebaceous Eipthelioma on the Lower Palpebral Conunctiva

PURPOSE: Sebaceous epithelioma which developed on the conjunctiva is a very rare benign skin and adnexal tumor. No case has been reported in the Republic of Korea. We report a case of sebaceous epithelioma on the lower palpebral conjunctiva. METHODS: A 69 year old man had visited with asymptomatic mass on lower palpebral conjunctiva. The mass was resected and biopsied for histological examination. RESULTS: Sebaceous epithelioma was diagnosed by histological examination.

A Case of Sebaceous Epithelioma / 대한피부과학회지

A 42-year-old woman was treated with total abdominal hysterectomy and bilateral salpingo- oophorectomy due to endometrial carcinoma 3 years ago, and has taken regular check-ups ever since. A 1.0cm-sized, yellow-orange colored, pedunculated mass had ben developed on her scalp about 1 year before. Excision showed an exophytic pedunculated, well-circumscribed nodule composed of predominant undifferentiated basaloid cells, some vacuolated sebocytes and numerous sebaceous duct like structures. There was no relapse during the follow-up of about 6 months. The development of sebaceous epithelioma in this case would be associated with Muir-Torre syndrome.

Multiple Adnexal Neoplasms Arising in Nevus Sebaceous / 대한피부과학회지

Nevus sebaceous occurs almost on the scalp and face and shows characteristically well demarcated yellowish patch or plaque. With time, benign or malignant skin tumors secondarily may be developed within nevus sebaceous lesion. We herein report a case of nevus sebaceous superimposed with 4 rare types of tumors; sebaceous epithelioma, syringocystadenoma papilliferum, tubular apocrine adenoma, and trichoblastoma.

A Case of Syringocystadenoma Papilliferum, Sebaceous Epithelioma, and Basal Cell Carcinoma Arising from Nevus Sebaceus / 대한피부과학회지

Nevus sebaceus is a congenital cutaneous hamartoma which has a potential to develop both benign and malignant neoplasm in late life. The most common benign tumor developed within the nevus is syringocystadenoma papilliferum and the most common malignant tumor basal cell epithelioma. Although two different tumors often develop simultaneously on the lesion, it is rare to see more than two different tumors developing on the lesion of nevus sebaceus. In Korean literatures only three such cases were reported. We report an additional case of nevus sebaceus developing three different tumors, syringocystadenoma papilliferum, sebaceous epithelioma, and basal cell carcinoma, in a 67-year-old female patient.

A Case of Sebaceous Epithelioma / 대한피부과학회지

We report a case of sebaceous epithelioma developed on the scalp of a 55-year-old man. Histopathologic examination revealed irregularly shaped cell aggregates partially connecting to the overlying epidermis. The majority of cells were undifferentiated basaloid cells, but some cells were sebaceous cells or transitional cells.

Two Cases of Sebaceous Epithelioma / 대한피부과학회지

Sebaceous epithelioma is a rare skin appendage tumor with sebaceous differentiation. It may occur as a primary lesion or may arise within a nevus sebaceus. We present two cases of sebaceous epithelioma developed on the scalp in a 55-year old woman and on the forehead in a 75-year old wornan. Histopathologically the tumors are composed of irregularly shaped cell masses. The majority of cells are undifferentiated basaloid cells, but some cells show differentiation toward sebaceous cells.

Sebaceous Epithelioma: A report of 2 cases

Sebaceous epithelioma is a relatively rare tumor, mostly occuring in the face or scalp. The histogenesis and clinical and pathological features of sebaceous epithelioma have not been clearly defined, and a few other diagnostic terms have been used so far instead of sebaceous epithelioma. Two cases of sebacous epitheliomas were presented. No recurrence or metastasis was observed in our cases, so sebaceous epithelioma is considered to be a benign tumor. A brief review of the literature, concerned about the biological behavior, histogenesis and pathological findings of the sebaceous epithelioma, was made.

A Case of Sebaceous Epithelioma / 대한피부과학회지

Sebaceous epithelioma is an uncommon and primary neoplasm of sebaceous gland. We report herein a case of sebaceous epithelioma in an 85-year-old female. Physical examination showed a solitary, 2.5 x 3.5cm sized, reddish. irregularly surfaced, and well defined tumor on the intercanthal area. Histopathological findings showed tumor parenchyma. romprised of several large nests of three kinds of epithelial cells, mature sebaceous cells, undifferentiated cells arranged in pa1isade fashion at the periphery of a cell nest, and transitional cells showing beginning fatty vacuolizatiorn of the cytoplasm. Electron micocopy revealed immature dark cells, transitional cells, and mature sebaceous cell which showed many scattered foci of sebaceous ditferentiation characterized by intracytoplasmic lipid droplets and glycogen particls.

A Case of Sebaceous Epithelioma Associated with a Nevus Sebaceus of Jadassohn / 대한피부과학회지

We observed a case of sebaceous epithelioma associated with a nevus sebaceus in a 25-year-old male. The tumor was bean-sized, dome-shaped nodule on the slightly yellowish plaque of nevus sebaceus. Histopathological finding shows undifferentiated cells which are arranged in a palisade fashion at the periphery of a cell mass and a fairly large number of transitional cells and groups of mature sebaeeous cells.