Development of a nomogram for predicting survival of patients with ovarian serous cystadenocarcinoma after based on SEER database / 浙江大学学报·医学版

To develop a survival time prediction model for patients with ovarian serous cystadenocarcinoma after surgery. A retrospective analysis of 5906 postoperative patients with ovarian serous cystadenocarcinoma in the surveillance, epidemiology, and end results (SEER) database from 2010 to 2015 was performed. The independent risk factors for long-term survival were analyzed with multivariate Cox proportional hazard regression model. The nomogram of 3-year and 5-year survival was developed by using R language. The receiver operator characteristic (ROC) curve and were used to test the discrimination of the model and the calibration diagram was used to evaluate the degree of calibration of the prediction model. The survival curves was conducted by the risk factors. Cox proportional hazard regression model showed that age, race, histological grade (poorly differentiated and undifferentiated), stage T (T2a, T2b, T2c, T3a, T3b and T3c), and stage M (M1) were independent factors for the prognosis of patients with ovarian serous cystadenocarcinoma after surgery. A nomogram was developed by the R language tool for predicting the 3-year and survival of patients through age, race, histological classification, stage T and stage M. The C-index was 0.688 and the areas under ROC curve of the nomogram for predicting 3-year and 5-year survival were 0.708 and 0.716, respectively. The results of the calibration indicated that the predicted values were consistent with the actual values in the prediction models. The survival time of patients with high-risk factors was shorter than that of patients with low-risk factors (<0.05). The developed nomogram in this study can be used to predict 3-year and 5-year survival of postoperative patients with ovarian serous cystadenocarcinoma, and it may be beneficial to guide clinical treatment.

Gene microarray analysis of ovarian serous cystadenocarcinoma-related genes based on TCGA / 中国病理生理杂志

[ ABSTRACT] AIM:To detect the differentially expressed genes associated with ovarian serous cystadenocarcino -ma ( OV) by microarray and to analyze the participated signaling pathway .METHODS:We analyzed 16 datasets of Affy-metrix GeneChip Human Exon 1.0 ST Arrays from The Cancer Genome Atlas ( TCGA) , including 8 OV and 8 normal ovary samples.The function of differential genes was determined by pathway and gene ontology ( GO) analysis.The probable functions of the key genes were predicted according to intergenic signal transduction network .RESULTS:The 1 144 genes were identified as distinctively expressed in OV (P<0.05), 747 of which were up-regulated and 397 were down-regula-ted.The GO analysis results showed that the altered genes were involved in 362 up-regulated and 160 down-regulated sig-nificant functions (P<0.05) related to cell cycle, DNA replication, cell proliferation, cell apoptosis, cell adhesion, etc. The pathways of the different genes were involved in the 59 enrichment-related pathways (P<0.05), 45 of which were up-regulated and 14 were down-regulated.Among the 59 pathways, cell cycle, P53 signaling pathway, DNA replication, path-ways in cancer, PI3K-Akt signaling pathway, ECM-receptor signaling pathway, cell adhesion molecules and cell apoptosis were related to tumor genesis , development and metastasis .As a result, 229 genes with significant functions and pathways in GO and pathway analysis were selected to construct signal transduction network ( Signal-Net), 4 of which, CDK1, PLK1, MCM3 and PGK1, were found to play key roles in OV signal regulation network .CONCLUSION: The OV shows abundant differentially expressed genes that play key roles in cancer-related signal pathways .

Spontaneous rupture of ovarian cystadenocarcinoma: pre- and post-rupture computed tomography evaluation / Ruptura espontânea de um cistoadenocarcinoma ovariano: avaliação tomográfica prée pós-ruptura

AbstractEpithelial ovarian tumors are the most common malignant ovarian neoplasms and, in most cases, eventual rupture of such tumors is associated with a surgical procedure. The authors report the case of a 54-year-old woman who presented with spontaneous rupture of ovarian cystadenocarcinoma documented by computed tomography, both before and after the event. In such cases, a post-rupture staging tends to be less favorable, compromising the prognosis.

ResumoOs tumores epiteliais correspondem à maioria das neoplasias ovarianas, sendo que eventuais rupturas estão mais relacionadas ao ato cirúrgico. Relatamos um caso de cistoadenocarcinoma ovariano em uma paciente de 54 anos com documentação tomográfica pré- e pós-ruptura espontânea. O estadiamento tumoral pós-ruptura tende a ser menos favorável, comprometendo o prognóstico desses pacientes.

Collision tumor of ovary: a rare combination of dysgerminoma and serous cystadenocarcinoma.

Collision tumors of ovary are rare neoplasms and most commonly consist of a teratoma with mucinous tumor. Combination of papillary serous cystsdenocarcinoma and dysgerminoma was yet to be reported. A twenty years female patient presented with a large tumor of right ovary. Microscopically it was diagnosed as a collision tumor of ovary composed of dysgerminoma and serous cystadenocarcinoma. Mixed tumour can arise from divergent differentiation of a single type of stem cell. But components of collision tumor must arise from separate clones. Possibility of collision tumour should always kept in mind during assessment of difficult ovarian tumors to avoid diagnostic error. Key words: Collision tumor, dysgerminoma and serous cystadenocarcinoma.

The relative frequency and histopathological pattern of ovarian masses - 11 year study at tertiary care centre.

Background: Ovarian tumours are one of the major cause of gynaecological problems in females and present marked variation in their histological types. Relative frequency of these lesions is different for Western and Asian countries. Aims & Objective: This study was designed to find out frequency of various histological patterns of ovarian tumours in patients attending Pathology department of a teaching institute in Gujarat. Material and Methods: A retrospective – series study was conducted on 337 cases of ovarian masses, reported from January 2002 to December 2012. Results: Mean age of the subjects was 33.6 years, ranging from 8 to 70 years. In a total 337 cases of ovarian masses, 197 (58.46%) were non-neoplastic and 140 (41.54%) were neoplastic. Among neoplastic lesions, 77.14% (108/140) were benign, 3.57% (5/140) were borderline and 19.29% (27/140) were malignant. The commonest non-neoplastic lesion was luteal cyst (59/197) followed by simple serous cyst (56/197). The commonest malignant tumour was serous cystadenocarcinoma (11/27) followed by mucinous cystadenocarcinoma (5/27). The commonest borderline tumour was borderline serous tumour (4/5). Conclusion: Non-neoplastic lesions were more common than neoplastic lesions. Among neoplastic lesions benign tumours were common. The commonest benign tumour was serous cystadenoma and malignant was serous cystadenocarcinoma. The commonest non-neoplastic lesion was luteal cyst. Among histological types of ovarian tumours, surface epithelial tumours dominated the other types.

Clear cell histology as a poor prognostic factor for advanced epithelial ovarian cancer: a single institutional case series through central pathologic review / 부인종양

OBJECTIVE: Compared with serous adenocarcinoma (SAC), clear cell carcinoma (CCC) often shows chemo-resistance, which would potentially lead to a poor prognosis. On the other hand, there have been arguments over prognoses of CCC and SAC disease. In the present study, multivariate analysis to compare prognosis of CCC patients with that of SAC was aimed for the patients selected from central pathologic review. METHODS: Between 1984 and 2009, a total of 500 ovarian cancer patients were treated at our university hospital. Among them, 111 patients with CCC and 199 patients with SAC were identified through central pathological review. Overall survival and progression-free survival were compared using Kaplan-Meier method, and prognostic factors were investigated by multiple regression analyses. RESULTS: Median age was 52 years for CCC and 55 years for SAC (p=0.03). The ratio of stage I patients were significantly higher in CCC compared with SAC (55% vs. 13%, p<0.01). Among evaluable cases, response rate was significantly lower in CCC than that in SAC (32% vs. 78%, p<0.01). No significant differences of progression-free survival and overall survival were observed in stage I patients; however, prognoses of CCC were significantly poorer than those of SAC in advanced-stage disease. In stage II-IV patients, not only residual tumors and clinical stages, but also clear cell histology were identified as predictors for poor prognosis. CONCLUSION: Clear cell histology was identified as a prognostic factor for advanced-stage ovarian cancers. Histologic subtypes should be considered in further clinical studies, especially for advanced epithelial ovarian cancers.

A case report of Pseudo-Meigs' syndrome associated with ovarian serous cystadenocarcinoma / 부인종양

Pseudo-Meigs' syndrome is a rare condition that includes hydrothorax and/or ascites secondary to ovarian neoplasms other than benign primary tumors. A 67-year-old woman presented with ascites, hydrothorax, left ovarian mass and elevated CA-125 level. The mass was removed and revealed serous cystadenocarcinoma. The immediate and complete resolution of symptoms and rapid decline of CA-125 level to normal value was achieved post-operatively. One month after surgery, she had no evidence of ascites or pleural effusion. We report Pseudo-Meigs' syndrome associated with ovarian serous cystadenocarcinoma and elevated CA-125 level.

A case report of Pseudo-Meigs' syndrome associated with ovarian serous cystadenocarcinoma / 부인종양

Pseudo-Meigs' syndrome is a rare condition that includes hydrothorax and/or ascites secondary to ovarian neoplasms other than benign primary tumors. A 67-year-old woman presented with ascites, hydrothorax, left ovarian mass and elevated CA-125 level. The mass was removed and revealed serous cystadenocarcinoma. The immediate and complete resolution of symptoms and rapid decline of CA-125 level to normal value was achieved post-operatively. One month after surgery, she had no evidence of ascites or pleural effusion. We report Pseudo-Meigs' syndrome associated with ovarian serous cystadenocarcinoma and elevated CA-125 level.

A Case of Parovarian Serous Cystadenocarcinoma of Borderline Malignancy / 대한산부인과학회잡지

Although parovarian cysts constitute 10-20% of all adnexal masses, malignant parovarian tumors are extremely rare. Due to the rarity of this lesion, there are controversies concerning the origin, clinical behavior, and prognosis of these tumors. Currently, it is suggested that these paovarian tumors should be treated similarly to their ovarian counterparts. We experienced one case of parovarian serous cystadenocarcinoma of borderline malignancy, and report this with a brief review of the literatures.

Differential Diagnosis of Ovarian Mucinous, Serous, and Endometrioid Adenocarcinoma in Peritoneal Washing Cytology / 대한세포병리학회지

This study presents the cytologic features of peritoneal washings, with particular emphasis on the cytologic discrimination among serous, mucinous, and endometrioid adenocarcinoma of the ovary. We selected histologically confirmed 27 cases of peritoneal washing : 8 cases of serous cystadenocarcinomas, 5 cases of mucinous cystadenocarcinomas, and 14 cases of endometrioid adenocarcinomas. The most frequent cytologic pattern of three tumors was clusters. Ball pattern was found in serous cystadenocarcinoma(36%) and acinar pattern in endometrioid adenocarcinoma (36%). Mucinous adenocarcinoma showed mucoid background(100%) and endometrioid adenocarcinoma revealed inflammatory background(43%). The cytoplasmic vacuoles were noted in 80%, 13%, and 43% of mucinous, serous, and endometrioid adenocarcinoma, respectively. The endometrioid adenocarcinoma showed prominent nucleoli(64%). In conclusion, the cytologic findings of mucinous cystadenocarcinoma were different from that of serous and endometrioid carcinomas, such as mucoid background, abundant cytoplasm with vacuolated cytoplasm, and peripherally located cytoplasm. Although endometrioid carcinoma showed acinar pattern and prominent nucleoli, the differential diagnosis between serous cystadenocarcinoma and endometrioid adenocarcinoma in peritoneal washing cytology was not always possible.

Carcinosarcoma in Recurrent Lesion of Serous Cystadenocarcinoma of the Ovary: A case report

Neoplasms showing both carcinomatous and sarcomatous features are well established, and have been reported in practically every organ where carcinoma can occur. But the difference in terminology and difficulties in histopathologic interpretation have hampered adequate understanding of these neoplasms. We report a case of carcinosarcoma in the recurrent form of serous cystadenocarcinoma of the ovary. The patient was a 64-year-old female who underwent total hysterectomy and bilateral salpingoophorectomy three years ago, due to perforated papillary serous cysta denocarcinoma of the right ovary. Recurrent pelvic masses contained both carcinomatous and sarcomatous components. Morphological transition between carcinomatous and sarcomatous components, and epithelial characteristics in the sarcomatous component by immunohistochemistry were recognized. We postulate the histopathogenetic mechanism based on the phenotypic conversion of carcinoma into sarcoma in the carcinosarcoma.

Effects of Dietary Salt Restriction in the Development of Renal Failure in the Excision Remnant Kidney Model

So-called sclerosing hemangioma of the lung is a rare benign neoplasm which usually presents with a coin lesion detected through routine chest X-ray. We report two cases showing characteristic cytologic appearances which have been rarely reported. Both cases were young females with coin lesions in the lung. Fine needle aspiration of each case revealed unique but some different cytologic features. Case 1 showed bland-looking polygonal epithelial cells resembling bronchioloalveolar cells having pre- dominantly papillary configurations with loosely arranged solid sheets or isolated cells. Cytoplasms were plump, cyanophilic, and finely granular, with eccentric nuclei, The nuclei were usually monotonous, round-to-ovoid, and vesicular with a small but conspicuous nucleolus. In comparison to case 1, case 2 revealed largely loose pavement-like solid sheets or clusters rather than papillary patterns in the hemorrhagic background. The size of tumor cells were a little smaller than that of case 1. Bronchioloalveolar carcinoma and papillary adenocarcinoma of metastatic origin were considered to be one of the important differential diagnoses with these cytologic features. Histologically, both cases exhibited findings compatible with so-called sclerosing hemangioma of the lung.