RESUMEN
Objective To observe the relationship between serum gamma-glutamyltransferase (GGT) and the risk factors of metabolic syndrome (MS). Methods Between April and August 2010, a total of 4110 persons from the out-patient Department of Tianjin First CentralHospital, were divided into two groups, the less than and the older than 65-year-old groups. Items as body mass index (BMI), blood pressure, FPG, serum total cholesterol(TC) ,triglyceride(TG) ,alanine transaminase (ALT) , aspartate aminotransferase (AST) , GGT, serum high-density lipoprotein level (HDL-C) , serum low-density lipoprotein level (LDL-C) and uric acid(UA) were tested and data was analyzed by SPSS. All subjects were divided into normaland abnormal groups, according to the GGT level. Results 14.6 percent of thesubjects in the younger groups and 24.3 percent in the older groups were diagnosed as MS. Significant differences were noticed among MS groups and normal groups, regarding items as BMI, dystolic, ALT, GGT, HDL-C, FPG, and UA(F<0.05). There were significant differences between GGT normal group and abnormal group (F<0.05). The GGT levels were significant positively related to the levels of BMI, dystolic, TC, TG, FPG and UA with Rs as 0.212, 0.226, 0.362,0.200,0.120 and 0.213 (P<0.01), while negatively related to the HDL-C level (r=-0.23, P<0.001). Data from the regression analysis demonstrated thatdystolic, TG, FPG and UA were predictors for GGT (β =0.170, 0.293, 0.107, 0.094, P<0.05). Conclusion GGT levels were significantly related to the risk factors of metabolic syndrome.
RESUMEN
Objective: The effects of alcohol consumption on coronary risk factors (CRFs) and insulin resistance (IR) have seemed equivocal in previous studies. This study aimed to clarify the implications of low fasting blood insulin observed in alcohol consumers as related to CRFs and IR. Methods: A cross-sectional observation in 2133 middle-aged healthy Japanese men for associations of increases in alcohol consumption, fasting serum insulin concentration and serum gamma-glutamyltransferase (GGT) activity with the major CRFs of high systolic blood pressure (SBP), fasting serum glucose, triglycerides (TG), total- and LDL-cholesterol (tCh & LDLc) and low serum HDL-cholesterol (HDLc). Results: Increased alcohol consumption was related to higher SBP, serum GGT, glucose and HDLc, and lower serum LDLc and insulin. Although high serum insulin was significantly related to all of the CRFs in all nondrinkers, moderate drinkers consuming up to 59 ml of alcohol per day and excessive drinkers consuming more, the means of SBP, serum glucose and HDLc were significantly higher and serum LDLc was lower in drinkers than in nondrinkers at any level of serum insulin, indicating that the good and bad profiles of CRFs in alcohol consumers are independent of their low fasting serum insulin. High serum GGT related to increased alcohol consumption and/or body weight was significantly associated with high serum insulin and all of the CRFs in all categories of alcohol consumption. Conclusions: Low fasting serum insulin observed in drinkers does not imply improved CRFs, and thus may not imply improved IR. High serum GGT may reflect increased IR in both drinkers and nondrinkers.