RESUMEN
Background & objectives: Previously there were reports from all over India about the changing spectrum of severe manifestations of Plasmodium falciparum malaria. Consequently, the present retrospective study was conducted to compare the severity of malaria caused by P. falciparum and P. vivax during 2007–08 and 2017–18. Methods: The present study was conducted on the patients admitted with severe malaria in a classified malaria ward of a tertiary care hospital in Bikaner, Rajasthan (Northwest India) during 2007–08 and 2017–18. It included adult patients of both sexes belonging to all age groups. The diagnosis was done by peripheral blood film (PBF), rapid diagnostic test (RDT), and validated by polymerase chain reaction (PCR). All patients were treated with intravenous oral quinine. The specific individual malaria complications registered in 2007–08 and 2017–18 were treated by following the standard WHO protocol. Results: In 2007–08, severe manifestations caused by P. falciparum were dominated by thrombocytopenia (25.98%) followed by jaundice (24.39%), multi-organ dysfunction (MODS) (16.66%), severe anemia (16.17%), cerebral malaria (5.39%), bleeding manifestation (3.92%) and shock (0.49%). While in the same year, P. vivax associated clinical spectrum of complications were observed to be dominated by thrombocytopenia (26.47%) followed by jaundice (25.00%), MODS (14.70%), severe anemia (5.88%), cerebral malaria (5.88%), renal failure (4.41%), bleeding manifestation (2.45%), shock (0.98%) and acute respiratory distress syndrome (ARDS) (0.49%). However, in 2017–18, the clinical spectrum of malaria complications caused by both species has changed. Relative to P. falciparum infections, P. vivax individual complications like thrombocytopenia (51.78%) (p<0.001) followed by jaundice (19.13%) (p<0.001) and severe anemia (4.22%) (p<0.05) were found to have increased significantly. Interpretation & conclusion: Over the last decade there is an apparent spatial and temporal shift in the clinical manifestations of severe malaria caused by the both Plasmodium species. As evident from the patient’s data from 2007–08 and 2017–18, the severity is more inclined towards Plasmodium vivax than Plasmodium falciparum malaria. Moreover, individual P. falciparum-associated complications were decreased significantly in the Bikaner region of Rajasthan, India
RESUMEN
Historical antecedents of erysipelas outbreaks in Chile, registered by national bibliography at years 1822 and 1873 are reviewed. The first one, after an earthquake, with numerous severe ataxo-adynamic manifestations and the second, more attenuated with few severe cases. Remembers of treatments utilized at XIX Century for the disease and the beginning of sulphamides prescription at the thirty decade are presented. Afterwards penicillin and other antimicrobial agents treatments were implemented. Finally, we comment the severe presentation of soft tissues streptococcal diseases that appeared in the end of XX Century.
Se revisa los antecedentes históricos de las epidemias de erisipela en Chile, que anota la bibliografía nacional, en los años 1822 y 1873. La primera, a continuación de un terremoto, con numerosas formas graves ataxo-adinámicas y la segunda, más benigna, con pocos casos graves. Se recuerda los tratamientos de la enfermedad utilizados en el siglo XIX y la iniciación de los antimicrobianos sulfamidados, en la década de los años 30. Posteriormente penicilina y otros antimicrobianos. Finalmente, se comenta la gravedad emergente de las infecciones estreptocóccicas de tejidos blandos, en los últimos años del siglo XX.