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Siddha system is mainly experienced in the Southern part of India. It is one of the most primitive traditional medicines in the world which treats not only the body but also the mind and the soul. The word Siddha derived from Tamil words “Siddhi” which means “An object to be Attained “or “perfection” or “heavenly bliss”. The aim of this review article is to explore the scientific literary evidences for the therapeutic usage of “Nilavaagai chooranam” for respiratory illness (Swasakasam, Iya noi) as mentioned in Siddha literature Siddha vaidaya Thirattu and to focus on the Pharmacological activity for the healing nature of the drug. Most of the raw drugs used for the preparation of Nilavaagai chooranam have Broncho dilatory activity, Anti-microbial activity, Anti-inflammatory activity, Immunomodulatory activity, Anti-histamine activity hence justifying its usage in respiratory ailments.
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Lumbar spondylosis is the degeneration of the spinal column from any cause. In the more narrow sense, it refers to spinal osteoarthritis. Yoga is an art and science of healthy living. It is one part of the Siddha system. It develops into a separate field and treating diseases. As per yogic scriptures, the practice of yoga leads to the union of individual consciousness with that of the Universal Consciousness. This is a case of lumbar spondylosis treated with yoga asana and Siddha medicine in an OP set up. The patient was given Siddha medicine in the form of internal oral and topical application. The present case report showed promotive effects of Siddha and yogic intervention on lumbar spondylosis.
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Background: Molecular docking has tremendous applications in the field of Siddha medicine especially herbal formulations were the interactions of the lead molecules of the formulation with that of receptors can be elucidated at the molecular level and furthermore to reach an assumption of its fundamental biochemical processes to which the formulation is targeting. Kuppaimeni Choornam (KC) is a simple herbal formulation used in Siddha medicine for urticaria and other skin allergies. As far as skin allergy is concerned Amino acids such as Asparagine (ASN), Tryptophan (Trp), Aspartate (Asp), Tyrosine (Tyr), Serine (Ser), Isoleucine (Ile), Lysine (Lys), Threonine (Thr), Phenylalanine (Phe) are the main core residues involved in mediating Human histamine receptor (3RZE). Binding of lead compounds with this core residue may inhibit the enzyme activity. Aim & Objectives: Molecular docking studies of Siddha herbal formulation KC and to screen the lead component interaction on the Human Histamine Receptor (3RZE). Methodology: Docking calculations were carried out using Auto Dock 4. Gasteiger partial charges were added to the ligand atoms. Docking simulations were performed using the Lamarckian genetic algorithm (LGA) and the Solis & Wets local search method. Initial position, orientation, and torsions of the ligand molecules were set randomly. All rotatable torsions were released during docking. Results and Conclusion: The compounds present in KC like beta-sitosterol, apigenin, luteolin, cuminaldehyde, kaempferol, and triacetonamine showed maximum interactions with 3RZE when compared to that of the standard cetirizine. Hence, these compounds of test drug possess promising Human histamine 1 receptor (3RZE) inhibition activity. For prospective pharmacological validation of Kuppaimeni Choornam, the docking studies were an important step for its scientific justification.
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Background: Siddha medicine is one of the commonest alternative medicine among AYUSH (ayurveda, yoga and naturopathy, unani, siddha, homeopathy) medicine practiced in Tamilnadu, one of the southern states of India, where it originated originally. To assess the knowledge, attitude and practice of siddha medicine practitioners towards Tuberculosis, a leading infectious disease-causing increased mortality and morbidity in the country where world’s one fifth of the diseased patients of tuberculosis live and how these alternative medicine practitioners are helping the national programme of eradicating TB in 2025 with their practice.Methods: A Questionnaire was prepared regarding the symptoms, investigations, treatment of TB and about its knowledge of recent trend. One siddha medicine practitioner was randomly selected from the 32 districts of the state from the registry, interviewed and assessed.Results: Out of the 32 siddha practitioners interviewed, 96% referred the tuberculosis patients to the nearby government hospitals for the antituberculous treatment but with the supportive siddha medicine. Regarding the awareness or update of the recent change in the TB regime and the national programme, only 10% of the siddha medicine practitioners were sensitised that too only those working in government hospitals.Conclusions: Siddha medicine practitioners mostly referred the tuberculosis patients, but they are insisting on the supportive role of siddha medicine along with the standard anti tuberculous drugs for the general improvement of the patient. Also, the sensitisation programmes for these Siddha practitioners should be initiated for the better outcome of the RNTCP (Revised National Tuberculosis Control Programme), especially in the private setup.
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Siddha Medicine is a traditional system of healing medicine in the southern part of the India and some other nations. This system of Medicine is mainly categorized into two classes, based on the root of admiration of the drugs, which are 32 types of Aga marunthugal (Internal medicine) and 32 types of Pura marunthugal (External medicine) for treating the 4448 diseases describe in the Siddha texts. The 32 types of External therapies are included in many kinds of external application of treatment procedures. Siddha texts mentioned the Pugai is termed as Fumigation is one of the external therapies in this system. This study reveals that the Pugai is the effective external treatment procedure to cure some disease condition based on Siddha theory. Fumigation signifies the artificial impregnation of the atmosphere, with the fumes or smoke of any vegetable or aromatic substances. Pugai is an application of fumes is administered in different parts of the body, apart from inhalation. Most of these therapies are aimed to maintaining the healthy balance of tri humours of Vatham, Pitham, Kabam and Saptha thathukkal which mean seven tissue types of the body. Main purpose of this procedure is to reduce microbes and to control infections. Fumigation can be effective in inactivating microbes on environmental surfaces.
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Objective: The present pilot study was designed to evaluate the efficacy of Seenthil sarkarai, a Classical Siddha medicine in Moothirakiricharam (Urinary Tract Infection) patients. Method: This study was approved by IEC and registered in Clinical Trial Registry of India and was conducted at the National Institute of Siddha, Tambaram, Chennai, India. The investigator recruited 20 patients of both male and female with an inclusion and exclusion criteria. All the patients were treated with Seenthil Sarkarai at the dose level of 2 grams two times a day with warm water for 21 days. Dietary regimen was advised for the patients. Study outcome was studied with negative Urine culture and also based on the improvement in the reduction of Burning micturition, Frequency of micturition, Dysuria with fever, Foul smelling urine. Results: The symptoms such as burning micturition, persistent urge to urinate, foul smelling urine, and presence of bacteriuria reduced markedly within 21 days of duration. Out of 20 patients, 12 patients were completely relieved from the compliance of UTI with negative Urine culture. The symptoms of UTI were markedly reduced in remaining 8 patients. There were no adverse effect reported during the study and no recurrence of UTI was noticed in 12 patients who were completely cured. Conclusion: Results suggest that the trial drug Seenthil Sarkarai is effective and safe for the management of Moothirakiricharam (UTI) and in alleviating recurrences.
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Mantha Sanni (Autism) is a Mukkuttra disease that is imbalance of all the three main fundamental principles of Vatham, Pitham and Kabam. Mantha Sanni is a neuro developmental disorder typically appearing in the first one and half years of life and characterised by impaired social and communication skills.. In the all over the world, the surveillance study identified 1 in 68 children suffering with ASD. In India, the prevalence ratio is 1:46. It is about 4.5 times more common among boys (1:48) than among girls (1:189). The higher prevalence rate was observed in the rural area. Socioeconomic status may be one of the fundamental indicators for ASD in India. Autism spectrum disorder is the world most common disorder in Children. In this study, I have to present 3 case reports of ASD children based on the assessment scale. The main course of treatment are Brami Nei as internal and Varmam as External therapy in the recommended dose as per Siddha pharmacopeia for 3 months. After 3 months, ASD children improve the cognitive skills and eye to eye contact Hyperactivity reduced well. Most of the formulation acting on psyche is ghee based. It is well established that the drugs to have its action on brain should have the capacity to cross the blood brain barrier and for the purpose ghee based Brahmi Nei is recommended for ASD in children. Manipulative therapy like Varma is to enhance the mind calming activity with sound sleep, good eye to eye contact and to reduce anxiety, hyperactivity. All the ingredients in both Internal medicines are herbal. So my attorney has to conclude the Siddha management therapy might be good and safest. It will be definitely efficacy in treating ASD children. Hence, Brami Nei as internal Varmam as External therapy may have a role to curing the ASD children.
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Siddha system of medicine is one of the ancient systems of medicine practiced among Tamil speaking community particularly in southern parts of India. The medicine in this system prepared from raw drugs which is obtained from herbals, mineral, metals and animal products. “Nilavaagaichooranam” is one of the Sastric Siddha herbo-mineral preparation with ingredients of 18 herbal and one mineral ingredient. It is used to treat the skin disorders particularly for “Karappan (Eczema)”. This review is aimed to bring out scientific evidence for the therapeutic usuage of “Nilavaagaichooranam” in skin disorders particularly in Karappan (Eczema) and focused on the pharmacological activity responsible for the curative nature of the drug in Karappan (Eczema). Most of the raw drugs used for the preparation of Nilavaagai chooranam have antihistamine activity, anti-inflammatory activity, immunomodulatory activity hence justifying its usage in Karappan (Eczema).
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Infertility is a common problem of new age couples. It is affecting them psychologically and also affecting the harmony of the family. Among infertility couples, 40% was caused by male partner particularly by oligospermia. Literally oligospermia means insufficient number of spermatozoa in semen, but significantly, it means that oligospermia is a medical condition characterized by the total sperm count less than 20 million/ml of ejaculate. Extensive clinical researches are going on worldwide to treat oligospermia by utilizing various natural sources like plants, mineral and animal origin. Siddha medicine is having many formulations to treat oligospermia, one among them is Dhathu bushti chooranam described in Noigalukku Siddha Parigaram –a Sasthiric siddha literature. 10 male partners of infertility couples attending Sool mahalir maruthuvam OPD of the Ayothidoss Pandithar Hospital, National Institute of Siddha, Tambaram sanatorium, Chennai-47 were recruited for this pilot study. All patients were treated with 10 gm of Dhathu bushti chooranam twice a day with milk for 90 days. All patients were subjected to complete semenogram on 0th and 90th day of treatment. Results were observed by analyzing the semenogram parameters. The ingredients of Dhathu bushti chooranam are Salamisiri, Nilapanai kizhangu,Thaneervittan kizhangu, Poonaikaali vidhai, Boomisarkkarai kizhangu and most of them are having good spermatogenesis and aphrodiasic activities, hence the author selected this drug for this study. The efficacy of the trial drug Dhathu bushti chooranam was appreciable and the drug may be taken for clinical trial in large number of population.
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Azhinjiathikashayam is a herbo mineral Siddha poly herbal formulation said for the management of Madhumegam (Type-2 Diabetes mellitus) in ancient Siddha literature. The study drug was subjected to estimate the therapeutic efficacy in Madhumegam patients. A well designed study protocol was approve by Institutional Ethics Committee and the clinical study was conducted as an open clinical trial in OPD/IPD of Ayothidoss pandithar Hospital of National Institute of Siddha Chennai. Based on the inclusion criteria 40 Madhumegam patients (Type -2 Diabetes mellitus) were enrolled in this study. Informed consent was obtained from each patient before study initiation. 60ml of Azhinjiathikashayam was administered orally before food twice a day for a period of 90 days and advised to follow the prescribed dietary regimen. All the baseline data, Laboratory investigations were recorded in the prescribed Case Report Form of each patient. Blood sugar level in fasting and postprandial was done once in 30 days and HbA1c was done before treatment (0th day) and after treatment (90th day). The clinical assessment was recorded once in 10 days. Paired ‘t’ test was used to test the significance of treatment using before and after treatment data on HbA1c, Clinical symptoms, Blood sugar fasting and postprandial. The level of significance probability 0.05 was used to test the treatment difference and the values are statistically significant. In this study there is statistically significant difference between before and after treatment on average HbA1c, average blood sugar of fasting and average clinical feature score (p < 0.0001).