RESUMEN
The basal forebrain is a heterogeneous structure at the base of the brain that participates in the regulation of sleep?wake, cognition, consciousness, and attention. Previous studies have suggested that these functions are mainly mediated by cholinergic neurons in the basal forebrain. With advances in research techniques, the understanding of basal forebrain cholinergic neurons, as well as GABAergic neurons and glutamatergic neurons, is deepened. The role of different neurons in the basal forebrain in the regulation of sleep?wake is summarized in this article. GABAergic neurons play a key role in promoting wakefulness, cholinergic neurons play an important role in sleep?wake homeostasis, and glutamatergic neurons provide excitation signals to other neurons.
RESUMEN
The basal forebrain is a heterogeneous structure at the base of the brain that participates in the regulation of sleep-wake, cognition, consciousness, and attention. Previous studies have suggested that these functions are mainly mediated by cholinergic neurons in the basal forebrain. With advances in research techniques, the understanding of basal forebrain cholinergic neurons, as well as GABAergic neurons and glutamatergic neurons, is deepened. The role of different neurons in the basal forebrain in the regulation of sleep-wake is summarized in this article. GABAergic neurons play a key role in promoting wakefulness, cholinergic neurons play an important role in sleep-wake homeostasis, and glutamatergic neurons provide excitation signals to other neurons.
RESUMEN
Narcolepsy is characterized by excessive daytime sleepiness, cataplexy, sleep paralysis and hypnagogic hallucinations. Only a few studies have focused on non-rapid eye movement (NREM) and REM parasomnias in narcolepsy. We report a narcolepsy without cataplexy patient presenting parasomnia as an initial symptom. A 18-year-old boy was admitted to hospital for abnormal behavior of sitting up during sleep over 2 years. He had a symptom of lethargy without cataplexy and subjective excessive daytime sleepiness, but his family found him often asleep during daytime. He underwent 3 times of polysomnography (PSG) including 1 multiple sleep latency test (MSLT) after the last PSG. The last PSG showed 1 episode of abrupt sitting. Three sleep REM onset period was observed in MSLT which was not detect in PSG. Parasomnia as an initial symptom of narcolepsy is a rare clinical entity. The MSLT may be useful in the evaluation of patients with parasomnia and unexplained hypersomnia.