Non-small cell lung cancer with both EGFR gene L861Q mutation and the first symptom of perforation due to small bowel metastasis: A case report / 肿瘤

Objective: To explore the treatment strategy for non-small cell lung cancer patients with both rare mutation (L861Q) of epidermal growth factor receptor (EGFR) gene and the first symptom of perforation due to small bowel metastasis. Methods: The medical records as well as the diagnosis and treatment process of a case of non-small cell lung cancer with both rare EGFR mutation and the first symptom of perforation due to small bowel metastasis were reviewed restropectively, to explore the treatment strategy. Results: The perforation was the first symptom in this non-small cell lung cancer patient with both rare EGFR mutation (L861Q) and small bowel metastasis. After the laparotomy and partial small intestine resection, afatinib was administered orally for 16 days according to the genetic test results until peritoneal effusion and enlarged lesions in the right lung was found, as well as liver, bilateral adrenal, brain parenchymal, vertebral and retroperitoneal lymph node metastases were assessed by CT and MR scan. Progressive disease with eventual death of vomiting occured, and the rescue is invalid. The overall survival time was 110 days after surgery. Conclusion: For non-small cell lung cancer patients with both rare EGFR mutation (L861Q) and small bowel metastasis, the prompt diagnosis and treatment against primary tumor are the keys to improve their prognosis. Rare EGFR mutations are heterogeneous and lack of standard treatment due to the low incidence. Further large-scale prospective randomized controlled studies are needed.

Malignant Mixed Mullerian Tumor with Small Bowel Metastasis: A Case Report

Malignant mixed Mullerian tumors (MMMT) are rare aggressive tumors that typically arise fromthe female genital tract. This malignancy has an extremely poor prognosis due to its rapid growthand the high associated incidence of both local recurrence and distant metastases. Althoughintraperitoneal metastasis from MMMT is relatively common, no reports exist regarding theradiologic findings of intestinal metastasis from MMMT. Here, we report a case of MMMT withsecondary small bowel metastasis and the associated radiologic findings.

Two Different Causes of Intestinal Obstruction in Lung Cancer / 결핵및호흡기질환

No abstract available.

Jejunal Intussusception with Gastrointestinal Bleeding Caused by Metastatic Lung Cancer / 대한소화기학회지

Intestinal intussusception caused by metastatic tumor is uncommon. Symptomatic small bowel metastases from lung cancer have been rarely reported. Here we report a case of intussusception with gastrointestinal bleeding induced by jejunal metastasis of non-small cell lung cancer with a review of the literature. A 52-year-old man was admitted to our hospital because of melena. He had underwent right pneumonectomy and received systemic chemotherapy with radiotherapy for squamous cell lung cancer. Esophagogastroduodenoscopy and colonoscopy failed to reveal bleeding focus. Abdominal CT scan revealed jejunal intussusception and histologic examination of resected jejunum showed metastatic mass from lung cancer. In patients with small bowel obstruction and history of malignancies, possibility of small bowel metastatic tumor should be considered.