RESUMEN
Natural products have always been one of the important sources of new chemical drugs. In recent years, with the continuous increase in the number of natural products reported, the separation and enrichment of new natural compounds have become more and more difficult, and the traditional high throughput screening methods have been unable to meet the needs of new drug development. Given its high efficiency and low cost, in silico(virtual)screening technology has gradually become indispensable in the research and development of new natural products. In this article, we introduce and compare the advantages and disadvantages of four in silico screening methods, collect and sort out the application cases of the virtual screening technology in the research of new natural products in recent years to provide a reference for researchers.