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AIM: To study effect of sodium ferulute on experimental arrhythmias. METHODS: Arrhythmias were induces by drugs and myocardial ischemia. RESULTS: Sodium ferulute 0.6 g·kg-1 iv antagonized arrhythmias induced by ouabain, adrenalin and myocardial ischemia (P < 0.01). but showed no effect on aconitine-induced arrhythmia. CONCLUSION: Sodium ferulute has effect on experimental arrhythmias. The mechanism of antiarrhymias is related to the block of potassium channel and β acceptor.
RESUMEN
AIM To study effect of sodium ferulute on experimental arrhythmias. METHODS Arrhythmias were induces by drugs and myocardial ischemia. RESULTS Sodium ferulute 0 6 g?kg -1 iv antagonized arrhythmias induced by ouabain, adrenalin and myocardial ischemia( P
RESUMEN
AIM To study sodium ferulute on monophasic action potential of ventricular muscle. METHODS Well being rabbits( n =20) were divided into 2 groups randomly,benzyltetrahydroplmatine(BTHP)group is a control group,the other is a study group. Franz's Quadrupole contact electrod catheter is advanced into the rigter ventricular by vein.MAP is recorded by traditional methods. At the same time Ⅱ lead ECG was recorded. Control group and study group were administered BTHP(5 mg?kg -1 ) and sodium ferulute(0 6 g?kg -1 ) respectively,before and after administration the duration of MAP at 20%(MAPD20),50%(MAPD50) and 90% (MAPD90) repolarization,amplitude of MAP (MAPA) and effective refractory period(ERP)were measured. RESULT In control group MAPD50,MAPD90 and ERP were significantly prolonged (124 5?8 96) ms vs (97 5?6 77) ms,(153?7 53) ms vs (123 5?5 8) ms,(142?13 37) vs (111?13 50) ms,respectively, P 0 05). CONCLUSION Sodium ferulute may be potassium channel blocker.