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[Objective]To evaluate the validity and feasibility of somatosensory evoked potentials(SEP) and transcranial magnetic stimulation motor evoked potential(TMS-MEP) in early decompression of spinal cord injury(SCI). [Method]Thirty-two rabbits fell into four groups randomly. The static load model were used to simulate human SCI. According to the compression time, the animals were divided into 4 groups (control,5min, 15min,30min). In this study, somatosensory evoked potentials (SEP) and transcranial magnetic stimulation motor evoked potential (TMS-MEP) were used to assess neurologic function. The EPs were recorded at 5min, 15min, 30min, 60min, 6 hours, 24 hours, 3 days, 7 days post-decompression and before spinal cord injury in injury groups. Latency and amplitude were measured for each wave. Tarlov behaviour score was performed before surgery and after surgery at 1,3,7 days. Histologic studies were performed on part of animals. [Result]Spinal cord compression resulted in a gradual increment in the peak latency and significant decrement in the peak amplitude. After decompression, the recovery of the latency was more obvious than the amplitude in all injury groups, EPs recovered earlier than Tarlov score. [Conclusion]EPs may evaluate the neurologic function of SCI models sensitively and impartially. Dcompression early may promote SCI recovery.
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@# ObjectiveTo observe effects of Naotong(NT) oral solution on the somatosensory evoked potentials(SEP) of acute cerebral infarction rats and its curative experimental.Methods24 model rats were randomly divided into three groups and treated with NT oral solution,Naoxuekang(NXK) and normal saline(NS) respectively for 20 days,the SEP and neurologic grades of the rat models were evaluated before and after treatment.ResultsAll the latencies of SEP(P1,N2,P2) in NT group was shorter than that of the pre-treatment and NS control group(P<0.01).The neurologic grades of both NT and NXK groups were highly lowered compared with pre-treatment and NS control group(both P<0.05).The latencies of SEP in the model rats were highly correlated with the neurologic grades(r=0.97～0.99,P<0.05～0.01).ConclusionNT can accelerate the nervous function recovery of the rat models with acute cerebral infarction.SEP may be used as a powerful index of observation on curative effect of acute cerebral infarction.
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@#ObjectiveTo observe effects of intravenous magnesium sulfate (MgSO 4) administration on ischemia reperfusion injury of the spinal cord in rabbits.MethodsNew Zealand White rabbits (n=27) were randomly divided into the group A (treated with MgSO4), group B (treated with saline) and group C (sham group) with 9 animals in each group. Ischemic model was established with midline laparotomy and clamping the aorta just distal to left renal artery and proximal to aortic bifurcation for 30 min followed by a reperfusion period of 48 h. Animals were treated with 0.25 ml/kg/h MgSO4 intravenous infusion in group A, treated with similar volume of saline as control in group B, and were anesthetized and subjected laparotomy without aortic occlusion in group C. Somatosensory evoked potentials (SEP) were monitored before ischemia, during ischemia and in the first 60 min of reperfusion. The neurological outcome was clinically evaluated up to 48 h post ischemia, and motor function was scored. The animals were sacrificed two days post ischemia, and spinal cords were processed for histopathological examination.ResultsSEP amplitudes and latencies in group C did not change during the procedures and all animals recovered without neurological deficits. The waves disappeared in group B and reduced to 29% of the initial amplitude at the end of the ischemia in group A. After 60 min reperfusion, SEP amplitudes returned gradually to 74% and 49% of the initial amplitude respectively (P<0.01) in groups A and B. The N1, P1 latencies returned gradually to (28.9±1.9) ms, (57.3±3.2) ms in group A and (30.7±0.9) ms, (61.2±2.9) ms in group B (P<0.05). The average motor function score in group A was significantly higher than that in group B at 24 h and 48 h after reperfusion (P<0.01).ConclusionMgSO4 intravenous infusion may relieve spinal cord injury and preserve neurological function in transient spinal cord ischemia in rabbits.
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BACKGROUND: The nerve conduction study (NCS) is one of the most important diagnostic tools used to evaluate the function of large myelinated nerve fibers. However, the NCS in patients with diabetic polyneuropathy, who have senso-ry and motor abnormalities on neurological examination, are frequently found to be within normal limits. Somatosensory Evoked Potentials (SEP), F-waves, and NCS were performed to determine their usefulness in detecting electrophysiologic abnormalities in the early stages of patients with diabetic polyneuropathy. METHODS: Posterior tibial SEP (PTSEP) studies were performed in thirty patients with clinically suspected diabetic polyneuropathy who had with-in normal values of NCS involving the upper and lower extremities. PTSEP, F-wave, and NCS were also performed in age and height matched eighteen normal participants. RESULTS: The mean latencies of spinal evoked potentials (T12) and cortical evoked potentials (P1) were significantly prolonged in the diabetic patients compared to the control group (p 0.05). CONCLUSIONS: We found the SEP study to be a useful diagnostic test for detecting diabetic polyneuropathy.