RESUMEN
Introduction:Various foods and aeroallergens are commonly attributed as the cause and exacerbating factors ofatopic dermatitis (AD) in children. This study aim to describe the common food and aeroallergensImmunoglobulin E (IgE) sensitisation pattern and the association between atopic dermatitis (AD)children of varying eczema severities and age groups.Methods:Patients who fulfil the criteria of AD were recruited and their eczema severities were assessed usingEczema Area and Severity Index (EASI) score. Skin prick test (SPT) was performed and serum totalIgE and specific IgE taken for 6 common foods (cow’s milk, soya, egg white, peanut, wheat andchicken) and 4 aeroallergens [cat dander (Felix domesticus) and house dust mites (Dermatophagoidespteronyssinus, Dermatophagoides farinae and Blomia tropicalis)]. IgE sensitisation was diagnosedpositive when the SPT yield a wheal of ≥3mm compared with the negative control and/or serumspecific IgE level of >0.35ku/L. Data was analysed using SPSS®v20.Results:Overall IgE sensitisation to at least one food and/or aeroallergen was 95%. The most prevalentfood allergen in Group A [≤1 year old] (n=10) was egg white in which both tests showed statisticalsignificant results when compared with Group B [>1 year old] (n=50). Other common food allergensincluded cow’s milk and peanut. D. pteronyssinus was the commonest aeroallergen. Aeroallergenswere significantly more prevalent in Group B when comparing both groups.Conclusion:Food and aeroallergen sensitisations were very common among AD children. Food allergens weremore common in infants and aeroallergens in older children. Bigger sample size may provide morerepresentative results.
RESUMEN
Canine atopic dermatitis (CAD) is an allergic skin disease with characteristic clinical features associated with immunoglobulin E (IgE) antibodies. Identification of the causative allergens is the diagnostic goal, which is essential to treat and manage CAD patients. CAD is commonly associated with environmental allergens surrounding the patients. For this reason, it is important for diagnostic tests to select allergens that are related to the environment of each country and each province. There are two main allergen-specific tests, serological IgE test (SAT) and intradermal skin test (IDT). SAT did not show direct cutaneous reaction but did show serological reaction against allergens. However, SAT is simpler and more convenient than IDT in small animal practice. In this study, we selected domestically prevalent allergens for SAT, including 60 food allergens and 60 inhalant allergens, and tested eight dogs tentatively diagnosed with CAD based on Favrot's criteria. Furthermore, IDT was performed on four dogs from the SAT group for comparison of SAT and IDT, and the results were very similar. In SAT, four types of mites (Bloomia tropicalis, Glycophagus domesticus, Euroglyphus maynei, and mite mixture 1 Korea; house dust mites), four types of molds (Botrytis cinerea, Alternaria alternata, mold fungi mixture 11, mold fungi mixture), and one type of pollen (tree pollen mix 3 Korea) induced a reaction in more than half of dogs tested. In IDT, all four dogs reacted positively to Dermatophagoides farinae, and three reacted positively to Dermatophagoides pteronyssinus and house dust. The mean agreement rate between SAT and IDT in this study was 76.3%. This is the first trial to apply local allergens for SAT in Korean veterinary medicine, and it might play an important role for diagnoses and management of animal allergic diseases.