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OBJECTIVE@#To summarize the research progress of stem cell transplantation in treating spinal cord injury (SCI) at different stages based on the pathophysiological mechanism of SCI.@*METHODS@#The relevant research literature at home and abroad was extensively reviewed to explore the impact of transplantation timing on the effectiveness of stem cell transplantation in treating SCI.@*RESULTS@#Researchers performed different types of stem cell transplantation for subjects at different stages of SCI through different transplantation approaches. Clinical trials have proved the safety and feasibility of stem cell transplantation at acute, subacute, and chronic stages, which can alleviate inflammation at the injured site and restore the function of the damaged nerve cells. But the reliable clinical trials comparing the effectiveness of stem cell transplantation at different stages of SCI are still lacking.@*CONCLUSION@#Stem cell transplantation has a good prospect in treating SCI. In the future, the multi-center, large sample randomized controlled clinical trials are needed, with a focus on the long-term effectiveness of stem cell transplantation.
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Humanos , Trasplante de Células Madre Hematopoyéticas , Neuronas , Recuperación de la Función/fisiología , Médula Espinal , Traumatismos de la Médula Espinal/cirugía , Trasplante de Células MadreRESUMEN
[Abstract] Objective To assess the effect of wogonoside on the inflammation after rat spinal cord injury. Methods Rats (n = 95) were subjected to dorsal spinal cord transection at T
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Spine cord injury is a kind of severe central nervous system trauma causing motion and sensation dysfunction. Treatment fo-cuses on controlling secondary injury cascade and improving regeneration which are heavily regulated by microRNAs (miRNAs). This re-view discussed the effect of miRNAs with different subtypes on spine cord injury, and investigated their potential roles as therapeutic agents in the personalized treatment of patients with spine cord injury.
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Spine cord injury is a kind of severe central nervous system trauma causing motion and sensation dysfunction. Treatment fo-cuses on controlling secondary injury cascade and improving regeneration which are heavily regulated by microRNAs (miRNAs). This re-view discussed the effect of miRNAs with different subtypes on spine cord injury, and investigated their potential roles as therapeutic agents in the personalized treatment of patients with spine cord injury.
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@#Objective To study the precaution and nursing for the acute complication after traumatic cervical spine cord injury. Methods 56 patients with acute traumatic cervical spine cord injury were analyzed retrospectively.Results All the complication had been cured and none died because of the complication. Conclusion It is important to do something to relieve or prevent the complication as soon as possible.