RESUMEN
Cutaneous clear cell squamous cell carcinoma in situ (SCCIS) or clear cell Bowen disease is an unusual variant of SCCIS characterized by a variable component of large clear cells. We report a case of a 73-year-old woman with a solitary facial erythematous nodule. Histologically, the skin lesion revealed nests of atypical clear cells with markedly vacuolated cytoplasm in the upper layer, lack of maturation and lack of polarity of keratinocytes in the epidermis. Electron microscopy showed clear cells with many empty spaces and lysosome-like structures, suggestive of clear cell changes caused by degenerative phenomenon.
Asunto(s)
Anciano , Femenino , Humanos , Enfermedad de Bowen , Carcinoma de Células Escamosas , Citoplasma , Epidermis , Queratinocitos , Microscopía Electrónica , PielRESUMEN
Squamous cell carcinoma in situ on the penis has been reported to have variable success and morbidity. A 71-year-old male patient with the condition was successfully treated with a topical application of 5% imiquimod cream, three times a week for 4 weeks. A biopsy specimen was obtained to confirm tumor clearance. There was no clinical evidence of any residual tumor 3 months after the therapy was completed. There was also no evidence of scarring, deformity or systemic side effects.
Asunto(s)
Anciano , Humanos , Masculino , Biopsia , Carcinoma de Células Escamosas , Cicatriz , Anomalías Congénitas , Neoplasia Residual , PeneRESUMEN
Many treatments for perianal squamous cell carcinoma in situ have been used. Surgery and cryotherapy, which are known to be the most effective treatment for this disease, may have high risk of cosmetic and functional deformity. We have treated squamous cell carcinoma in situ in renal transplant patient with 5% imiquimod successfully. With the experience of our treatment for squamous cell carcinoma in situ, 5% imiquimod cream can be an alternative treatment option of squamous cell carcinoma in situ of anus.