Impact of salvianolic acid B on cognitive function and GSK-3β/β-Catenin signaling pathway in rats with post-traumatic stress disorder / 天津医药

Objective To investigate whether salvianolic acid B(Sal B)can improve the cognitive function in rats with post-traumatic stress disorder(PTSD)by regulating GSK-3β/β-Catenin signal pathway.Methods Sixty rats were randomly grouped into the normal group,the PTSD group,the Sal B low-dose group(10 mg/kg),the Sal B high-dose group(20 mg/kg)and the GSK-3β inhibitor group(30 mg/kg CHIR-99021),with 12 rats in each group.In addition to the normal group,rats in other groups were constructed PTSD rat models by using single prolonged stress(SPS)method.Open field test and Morris water maze test were applied to evaluate the cognitive function of rats.Nissl staining was applied to observe the pathological changes of hippocampal neurons.TUNEL staining was applied to detect the apoptosis of hippocampal neurons.Western blot assay was applied to detect the expression of cleared caspase-3,B-cell lymphoma gene-2-associated X protein(Bax),proto-oncogene(c-Myc),Cyclin D1,total GSK-3β(t-GSK-3β),phosphorylated GSK-3β(p-GSK-3β),total β-Catenin(t-β-Catenin)and phosphorylated β-catenin(p-β-Catenin)proteins in hippocampus.Results Compared with the PTSD group,the number of crawling spaces,standing times,total movement distance and times of crossing the original platform of rats were higher in the Sal B low-dose group,the Sal B high-dose group and the GSK-3β inhibitor group.The escape latency and the time to cross the original platform for the first time were shorter,the apoptosis rate of hippocampal neurons and the expression levels of Bax,cleaved caspase-3,t-GSK-3β and p-β-Catenin proteins in hippocampus were lower,and the expression levels of Cyclin D1,c-Myc,p-GSK-3β,t-β-Catenin proteins were higher(P＜0.05).Conclusion Sal B can reduce the apoptosis and damage of hippocampal neurons in rats with PTSD and improve cognitive dysfunction in rats,and inhibit the GSK-3β/β-Catenin signal pathway.

Influencing factors of post-traumatic stress disorder in patients with acute myocardial infarction after percutaneous coronary intervention / 心血管康复医学杂志

Objective:To study influencing factors of post-traumatic stress disorder(PTSD)in patients with acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods:According to score of PTSD checklist-civilian version(PCL-C),a total of 200 AMI patients undergoing PCI in our hospital were divid-ed into non-PTSD group(n=144,＜44 scores)and PTSD group(n=56,≥44 scores).General clinical data,scores of event related rumination inventory(ERRI),Eysenck personality questionnaire(EPQ)and social support rating scale(SSRS)were compared between two groups.Influencing factors of PTSD in AMI patients after PCI were analyzed.Results:There were 56 cases(28.00％)developing PTSD among the 200 AMI patients undergoing PCI.Compared with non-PTSD group,there were significant rise in age,percentage of hypertension,scores of in-vasive rumination of ERRI and neuroticism of EPQ,and significant reductions in percentage of living in town,scores of active rumination and internal & external of ERRI and SSRS in PTSD group(P＜0.05 or＜0.01).Multiva-riate Logistic regression analysis indicated that age and score of SSRS were independent protective factors for PTSD in AMI patients after PCI(OR=0.885,0.602,P=0.024,0.035),and scores of invasive rumination and neuroti-cism were independent risk factors for it(OR=2.986,3.360,P=0.032,0.025).Conclusion:Incidence rate of PTSD is higher in patients with acute myocardial infarction after PCI.Age,social support,scores of neuroticism and invasive rumination were influencing factors of PTSD in patients with acute myocardial infarction after PCI.

Functional near infrared imaging of college students on speech fluency tasks in traumatized / 中国学校卫生

Objective@#The study aims to explore the neural mechanism of cognitive differences in college students with posttraumatic stress disorder under verbal fluency task based on functional near infrared spectroscopy (fNIRS), so as to provide neuroimaging support for the evaluation, diagnosis and treatment of posttraumatic stress disorder(PTSD).@*Methods@#Posttaumatic Stress Disorder Checklist Combat(PCL-C) was used to screen the subjects, including 21 students in PTSD group (PCL-C≥38) and 30 students in control group from September to Novenber in 2020. A 53 channel near infrared spectroscopy device was used to collect cerebral blood oxygen signals under the verbal fluency task, and correlation analysis, Mann Whitney U test and independent sample t test were performed on the results.@*Results@#The difference in the total average score of PCL-C Scale between PTSD group and the control group(46.38±6.96，25.57±6.09) was statistically significant ( t=11.33, P <0.05). Correlation analysis showed that Avg-HbO in left dorsolateral prefrontal lobe was negatively correlated with PCL-C Score ( r=-0.37, P <0.05). Mann Whitney U test showed that in the left dorsolateral prefrontal lobe (Ch6), the Avg-HbO change in PTSD group [0.19(-0.09, 0.86)mmol/(L〖KG*7〗·mm)] was significantly lower than the control group [0.79( 0.37 , 1.47)mmol/(L ·mm)] ( Z=2.16, P <0.05), which was statistically significant.@*Conclusions@#The degree of PTSD was negatively correlated with the index of oxygenated hemoglobin in the left dorsolateral prefrontal lobe, and the oxygenated hemoglobin content in the PTSD group was lower than that in the normal group. In the future, fNIRS may be used to collect blood oxygen signals from the left dorsolateral prefrontal lobe in cognitive tasks to provide imaging evidence for the identification of PTSD.

Nurses' workload during the COVID-19 pandemic: potential for experiences of moral distress / Carga de trabajo de las enfermeras durante la pandemia de COVID-19: potencial para experiencias de sufrimiento moral / Sobrecarga de trabalho de enfermeiros na pandemia de COVID-19: potência para vivências de sofrimento moral

ABSTRACT Objectives: to understand nurses' experiences of moral distress related to work overload during the COVID-19 pandemic in Brazil. Methods: qualitative research, whose data collection occurred through individual interviews with 19 nurses who worked on the front line of COVID-19 in health services in southeastern Brazil. Data were analyzed using thematic content analysis. Results: work overload proved to be a powerful source of experiences of moral distress due to excessive working hours during vaccination, double working hours, a troubled relationship due to pressure from managers and the population and physical and mental exhaustion, which prevented nurses from act according to their judgment. Final Considerations: nurses' work overload reflects on quality patient care and prevents nurses from acting in accordance with their moral principles, generating moral distress in nurses.

RESUMEN Objetivos: comprender las experiencias de angustia moral de los enfermeros relacionadas con la sobrecarga de trabajo durante la pandemia de COVID-19 en Brasil. Métodos: investigación cualitativa, cuya recolección de datos ocurrió a través de entrevistas individuales con 19 enfermeros que actuaron en la primera línea de COVID-19 en servicios de salud de la región Sudeste de Brasil. Los datos fueron analizados mediante análisis de contenido temático. Resultados: la sobrecarga de trabajo resultó ser una poderosa fuente de experiencias de sufrimiento moral por exceso de jornada durante la vacunación, doble jornada laboral, relaciones conflictivas por presiones de los directivos y la población y agotamiento físico y mental, lo que impidió al enfermero actuar según su criterio. Consideraciones Finales: la sobrecarga de trabajo de las enfermeras se refleja en la calidad de la atención al paciente e impide que las enfermeras actúen de acuerdo con sus principios morales, generando sufrimiento moral en las enfermeras.

RESUMO Objetivos: compreender vivências de sofrimento moral de enfermeiros relacionadas à sobrecarga de trabalho durante a pandemia de COVID-19 no Brasil. Métodos: pesquisa qualitativa, cuja coleta de dados ocorreu através de entrevistas individuais com 19 enfermeiros que atuaram na linha de frente da COVID-19 em serviços de saúde da região Sudeste do Brasil. Os dados foram analisados mediante análise temática de conteúdo. Resultados: a sobrecarga de trabalho mostrou-se potente fonte para vivências de sofrimento moral devido à jornada de trabalho excessiva na vacinação, à dupla jornada de trabalho, à relação conturbada por pressão de gestores e população e ao esgotamento físico e mental, os quais impediam o enfermeiro de agir conforme o seu julgamento. Considerações Finais: a sobrecarga de trabalho dos enfermeiros reflete na assistência de qualidade ao paciente, e impede que os enfermeiros atuem conforme os seus princípios morais, gerando sofrimento moral nos enfermeiros.

Nascer no Brasil II: protocolo de investigação da saúde materna, paterna e da criança no pós-parto / Nacer en Brasil II: protocolo de investigación en salud materna, paterna e infantil posparto / Birth in Brazil II: a postpartum maternal, paternal and child health research protocol

Resumo: A gravidez, o parto e o nascimento são momentos de grandes mudanças na vida das mães e dos pais. Este artigo tem como objetivo apresentar o protocolo da pesquisa para estimar a prevalência dos desfechos em saúde mental nas mães e pais no pós-parto, dos maus tratos e satisfação na atenção ao parto/abortamento, e as inter-relações entre eles e fatores socioeconômicos, obstétricos e da saúde da criança. A pesquisa tem dois componentes: estudo de coorte prospectiva com todas as puérperas entrevistadas nas 465 maternidades incluídas na linha de base da pesquisa Nascer no Brasil II realizada entre 2021 e 2023, e estudo seccional com os companheiros/pais dos bebês. As entrevistas são realizadas por ligação telefônica ou link de autopreenchimento enviado por WhatsApp com as puérperas aos 2 e 4 meses após o parto/aborto. Os companheiros são abordados três meses após o nascimento (excluídos os abortos, natimortos e neomortos), a partir do telefone informado pela puérpera na maternidade. As entrevistas abordam, entre as puérperas, sintomas de depressão, ansiedade e transtorno de estresse pós-traumático, maus-tratos na atenção na maternidade e qualidade do vínculo mãe-bebê. São investigados também a presença de morbidade materna e neonatal, utilização de serviços pós-natais, e satisfação com o atendimento na maternidade. Entre os pais, é abordada a ocorrência de sintomas de depressão e ansiedade, e a qualidade do relacionamento com a esposa/companheira e o bebê. As informações coletadas nessa etapa da pesquisa poderão subsidiar o planejamento e melhoria do cuidado voltado para a saúde da tríade mãe-pai-filho após o nascimento.

Resumen: El embarazo, el parto y el nacimiento son momentos de grandes cambios en la vida de madres y padres. Este artículo tiene como objetivo presentar el protocolo de investigación para estimar la prevalencia de los resultados de la salud mental en madres y padres en el posparto, maltratos y la satisfacción durante la atención del parto/aborto, y las interrelaciones entre ellos y los factores socioeconómicos, obstétricos y de salud infantil. La investigación tiene dos componentes: un estudio de cohorte prospectivo con todas las puérperas entrevistadas en las 465 maternidades incluidas en la línea de base de la encuesta Nacer en Brasil II realizada entre 2021 y 2023, y un estudio seccional con las parejas/padres de los bebés. Las entrevistas se efectúan mediante llamada telefónica o enlace de autocumplimentación enviado vía WhatsApp a las puérperas a los 2 y 4 meses después del parto/aborto. El contacto con la pareja se hace a los tres meses del nacimiento (excluyendo abortos, mortinatos y muertes de recién nacidos), a través del teléfono facilitado por la puérpera en la sala de maternidad. Las entrevistas abordan, entre las puérperas, los síntomas de depresión, ansiedad y trastorno de estrés postraumático, maltrato durante la atención en la maternidad y la calidad del vínculo madre-bebé. También se investiga la presencia de morbilidad materna y neonatal, uso de servicios posnatales y satisfacción con la atención en la maternidad. Entre los padres, se aborda la ocurrencia de síntomas de depresión y ansiedad, y la calidad de la relación con la esposa/pareja y el bebé. La información recopilada en esta etapa de la investigación puede apoyar la planificación y mejora de la atención dirigida a la salud de la tríada madre-padre-hijo después del nacimiento.

Abstract: Pregnancy, parturition and birth bring major changes to the lives of mothers and fathers. This article presents a research protocol for estimating the prevalence of postpartum mental health outcomes in mothers and fathers, abuse and satisfaction in delivery/abortion care, and the correlations between them and socioeconomic, obstetric, and child health factors. As a 2-component research, it consists of a prospective cohort study with all postpartum women interviewed in the 465 maternity hospitals included at the Birth in Brazil II baseline survey conducted from 2021 to 2023, and a cross-sectional study with the newborns' fathers/partners. Interviews will be conducted via telephone or self-completion link sent by WhatsApp with the mother at 2 and 4 months after delivery/abortion. Partners will be approached three months after birth (excluding abortions, stillbirths and newborn death) using the telephone number informed by the mother at the maternity ward. Postpartum women will be inquired about symptoms of depression, anxiety and post-traumatic stress disorder, abuse during maternity care and quality of the mother-newborn bond. Maternal and neonatal morbidity, use of postnatal services, and satisfaction with maternity care are also investigated. Fathers will be asked to report on symptoms of depression and anxiety, and the quality of the relationship with the partner and the newborn. The information collected in this research stage may help to plan and improve care aimed at the postpartum health of the mother-father-child triad.

Experiences of women with physical disabilities in labor and delivery assistance / Experiencias de mujeres con discapacidad física en la asistencia durante el trabajo de parto y parto / Vivências de mulheres com deficiência física na assistência ao trabalho de parto e parto

ABSTRACT Objective: To understand the meaning attributed by women with physical disabilities to the health care received and expected during labor and delivery. Methods: Qualitative study, based on Social Network Theory, conducted through an online workshop in April 2022, with the participation of six women with physical disabilities. Data, collected through the focus group technique, underwent thematic content analysis with the assistance of the IRaMuTeQ tool. Results: Three thematic categories emerged: Challenges experienced during pregnancy; The experience within the maternity ward; and, The importance of social networks. The assistance provided by healthcare professionals sometimes differed between what was expected and what was received by women with physical disabilities during labor and delivery. Final Considerations: Experiences were predominantly negative, resulting from inappropriate professional conduct due to ableist attitudes. Support from members of social networks is crucial for preventing stressors.

RESUMEN Objetivo: Comprender el significado atribuido por mujeres con discapacidad física a la asistencia de salud recibida y esperada durante el trabajo de parto y parto. Métodos: Estudio cualitativo, fundamentado en la Teoría de Redes Sociales, llevado a cabo mediante un taller en línea en abril de 2022, con la participación de seis mujeres con discapacidad física. Los datos, recopilados mediante la técnica de grupo focal, fueron sometidos a análisis de contenido temático con la ayuda de la herramienta IRaMuTeQ. Resultados: Emergieron tres categorías temáticas: Problemas experimentados durante el embarazo; La experiencia dentro de la maternidad; y La importancia de las redes sociales. La asistencia proporcionada por los profesionales de la salud, en ocasiones, difirió entre lo esperado y lo recibido por las mujeres con discapacidad física durante el trabajo de parto y parto. Consideraciones finales: Las experiencias fueron predominantemente negativas, resultado de conductas profesionales inadecuadas debido a actitudes capacitistas. El apoyo de los miembros de las redes sociales es fundamental para la prevención de factores estresores.

RESUMO Objetivo: Compreender o significado atribuído por mulheres com deficiência física à assistência de saúde recebida e esperada durante o trabalho de parto e parto. Métodos: Estudo qualitativo, fundamentado na Teoria de Rede Social, realizado por meio de uma oficina online em abril de 2022, com a participação de seis mulheres com deficiência física. Os dados, coletados por meio da técnica de grupo focal, foram submetidos à análise de conteúdo temático com o auxílio da ferramenta IRaMuTeQ. Resultados: Três categorias temáticas emergiram: Problemas vivenciados na gravidez; A experiência dentro da maternidade; e A importância das redes sociais. A assistência prestada pelos profissionais de saúde, por vezes, diferiu entre o esperado e o recebido pelas mulheres com deficiência física durante o trabalho de parto e parto. Considerações Finais: As vivências foram predominantemente negativas, resultantes de condutas profissionais inadequadas devido a atitudes capacitistas. O apoio dos membros das redes sociais é fundamental para a prevenção de fatores estressores.

Association between patient safety culture and professional quality of life among nursing professionals / Asociación entre la cultura de seguridad del paciente y la calidad de vida profesional de los profesionales de enfermería / Associação entre cultura de segurança do paciente e qualidade de vida profissional de trabalhadores de enfermagem

ABSTRACT Objective: To analyze the association between patient safety culture and professional quality of life in nursing professionals. Method: Correlational study carried out in a hospital in Salvador, Bahia, Brazil, with 180 participants. The data were collected through the Hospital Survey on Patient Safety Culture and Professional Quality of Life Scale and analyzed with correlation tests. Results: The use of the Quality of Professional Life model, which encompasses Compassion Satisfaction, Burnout and Traumatic Stress, showed that a better assessment of the safety culture was negatively associated with Burnout. Regarding the dimensions of culture, better evaluations of the general perception of safety, teamwork and staffing were negatively associated with Burnout and Traumatic Stress. Higher Burnout was negatively associated with better handoffs and greater Traumatic Stress was positively associated with error communication. Conclusion: Higher levels of Burnout were associated with worse perception of safety culture and worse teamwork evaluations; staffing and general perception of safety were associated to a higher level of Burnout and Traumatic Stress, which emphasizes the importance of investment in these areas.

RESUMEN Objetivo: Analizar la asociación entre la cultura de seguridad del paciente y la calidad de vida profesional de los profesionales de enfermería. Método: Estudio correlacional realizado en un hospital de Salvador, Bahía, Brasil, con 180 participantes. Los datos fueron recolectados a través de los instrumentos Hospital Survey on Patient Safety Culture y Professional Quality of Life Scale y analizados con pruebas de correlación. Resultados: El uso del modelo de Calidad de Vida Profesional, que engloba la Satisfacción por compasión, el Burnout y el Estrés Traumático, demostró que una mejor evaluación de la cultura de seguridad se asoció negativamente con el Burnout. Respecto a las dimensiones de la cultura, mejores evaluaciones de la percepción general de la seguridad, el trabajo en equipo y la dotación de personal se asociaron negativamente con el Burnout y el estrés traumático. Un mayor Burnout se asoció negativamente con un mejor cambio de turno y un mayor estrés traumático se asoció positivamente con la comunicación de errores. Conclusión: Mayores niveles de Burnout se asociaron con peor percepción de la cultura de seguridad y peores evaluaciones del trabajo en equipo; la dotación de personal y la percepción general de seguridad se asociaron con un mayor nivel de Burnout y Estrés Traumático, lo que enfatiza la importancia de la inversión en estas áreas.

RESUMO Objetivo: Analisar a associação entre cultura de segurança do paciente e qualidade de vida profissional de trabalhadores de enfermagem. Método: Estudo correlacional, realizado em um hospital de Salvador-BA, com 180 participantes. Os dados foram coletados por meio do Hospital Survey on Patient Safety Culture e da Professional Quality of Life Scale e analisados por testes de correlação. Resultados: O emprego do modelo Qualidade de Vida Profissional, que engloba a Satisfação por compaixão, o Burnout e o Estresse Traumático, permitiu verificar que melhor avaliação da cultura de segurança esteve associada negativamente ao Burnout. Referente às dimensões da cultura, melhores avaliações na percepção geral da segurança, trabalho em equipe e dimensionamento de pessoal associaram-se negativamente ao Burnout e ao Estresse Traumático. Maior Burnout associou-se negativamente à melhor passagem de plantão e maior Estresse Traumático positivamente à comunicação sobre erro. Conclusão: Maiores níveis de Burnout estiveram associados à pior percepção da cultura de segurança e piores avaliações acerca do trabalho em equipe; dimensionamento e percepção geral da segurança se associaram ao maior nível de Burnout e de Estresse Traumático, destacando a importância de investimentos nessas áreas.

Adaptación transcultural del instrumento Intensive Care Psychological Assessment Tool en Colombia / Cross-Cultural adaptation of the Intensive Care Psychological Assessment Tool in Colombia / Adaptação transcultural do instrumento Intensive Care Psychological Assessment Tool na Colômbia

La hospitalización de una persona en unidad de cuidados intensivos (UCI) puede generar alteraciones mentales y físicas post internación; en Colombia existen pocas investigaciones para la detección anticipada de morbilidad psicológica en UCI. Este estudio busca generar una versión al español equivalente al instrumento Intensive Care Psychological Assessment Tool (IPAT). Se realizó una traducción directa e inversa del instrumento, previa autorización de los autores se incluyó participación de profesionales lingüistas en las traducciones. Se aplicaron entrevistas a personas de diferentes perfiles sociodemográficos hospitalizadas en UCI, para verificar la adecuación cultural y comparación de la versión colombiana con la versión original. Se encontraron que los ítems 1, 2, 3, 4 y 5 presentaron comprensibilidad del 100%, los restantes ítems 6, 7, 8 y 9 comprensibilidad del 97,5% y el ítem 10 una compresibilidad del 90% que requirió modificaciones. Las medidas de soporte vital como la ventilación mecánica, experiencias traumáticas y recuerdos de la hospitalización, han demostrado ser factores para desarrollar: Ansiedad depresión y trastorno de estrés postraumático, se espera que este estudio sea un punto de referencia para nuevas investigaciones basadas en adaptaciones transculturales de enfermería en Latinoamérica respecto a morbilidad psicológica. La versión colombiana del instrumento IPAT derivada por la adaptación transcultural es equivalente a la inglesa. El estudio sirve como inicio de nuevas investigaciones que busquen desarrollar un instrumento en español personalizado y verificado, y que pueda ser utilizado de forma habitual por el personal de enfermería en un futuro próximo.

Hospitalization in the intensive care unit (ICU) can result in mental and physical disturbances post-hospitalization. In Colombia, there is little research exploring the early detection of psychological morbidity in the ICU. This study aimed to develop a version of the Intensive Care Psychology Assessment Tool (IPAT) in Spanish equivalent to the original instrument. Direct and reverse translations of the IPAT instrument were carried out with prior authorization from the authors and the participation of professional linguists. People with different sociodemographic profiles, hospitalized in the ICU, were interviewed to confirm the cultural adequacy of the Colombian version, as well as to compare it with the original version. It was found that items 1, 2, 3, 4, and 5 presented 100% comprehensibility, items 6, 7, 8, and 9 had 97.5% comprehensibility, and item 10 had 90% comprehensibility, requiring modifications. Life support measures such as mechanical ventilation, traumatic experiences, and memories of the hospital stay were detected as factors for the development of anxiety, depression, and post-traumatic stress disorder. It is hoped that this study will be a reference point for new research based on cross-cultural adaptations related to psychological morbidity, in the nursing field in Latin America. The Colombian version of the IPAT instrument derived from this cross-cultural adaptation is equivalent to the English one. This study represents a starting point for new research that aims to develop a personalized and validated instrument in Spanish that can be used regularly by nursing staff in the near future.

A internação de uma pessoa na unidade de terapia intensiva (UTI) pode gerar alterações mentais e físicas pós-internação; na Colômbia há poucas pesquisas para a detecção precoce de morbidade psicológica na UTI. Este estudo busca gerar uma versão em espanhol equivalente ao instrumento Intensive Care Psychology Assessment Tool (IPAT). Foi realizada tradução direta e reversa do instrumento IPAT, com autorização prévia dos autores, foi incluída a participação de linguistas profissionais nas traduções. Serão aplicadas entrevistas com pessoas de diferentes perfis sociodemográficos internadas na UTI, para verificar a adequação cultural e comparação da versão colombiana com a versão original. Verificou-se que os itens 1, 2, 3, 4 e 5 apresentaram 100% de compreensibilidade, os demais itens 6, 7, 8 e 9 tiveram 97,5% de compreensibilidade e o item 10 teve 90% de compreensibilidade que necessitou de modificações. Medidas de suporte à vida, como ventilação mecânica, experiências traumáticas e memórias de hospitalização, demonstraram ser fatores no desenvolvimento de: ansiedade, depressão e transtorno de estresse pós-traumático, espera-se que este estudo seja um ponto de referência para novas pesquisas baseadas em estudos cruzados de adaptações culturais da enfermagem na América Latina em relação à morbidade psicológica. A versão colombiana do instrumento IPAT derivada da adaptação transcultural é equivalente à inglesa. O estudo serve como início de novas pesquisas que buscam desenvolver um instrumento personalizado e verificado em espanhol, e que possa ser utilizado regularmente pela equipe de enfermagem em um futuro próximo.

Frequência de sintomas sugestivos de transtorno de estresse agudo em pacientes queimados / Frequency of symptoms suggestive of acute stress disorder in burn patients / Frecuencia de síntomas sugestivos de trastorno de estrés agudo en pacientes quemados

As queimaduras são um sério problema de saúde pública devido aos altos custos financeiros e aos impactos físicos, psicológicos e sociais nos indivíduos afetados. Este artigo apresenta um estudo transversal, que investigou a possível ocorrência do transtorno de estresse agudo em pacientes vítimas de queimaduras, a partir do levantamento de sintomas sugestivos do transtorno em pacientes hospitalizados em uma unidade de queimados, com base em uma amostragem não probabilística e de conveniência. Os resultados indicaram que a margem de transtorno de estresse agudo em pacientes que foram internados na unidade de queimados da instituição estudada está próxima à prevalência prevista pelo Manual Diagnóstico e Estatístico de Transtornos Mentais, que é de 10%. A pesquisa mostra a importância de se considerar os impactos psicológicos das queimaduras e a necessidade de políticas públicas que possam ajudar a prevenir e tratar esses transtornos em pacientes afetados.

Burns are a serious public health problem due to the high financial costs and physical, psychological, and social impacts on affected individuals. This article presents a cross-sectional study that investigated the possible occurrence of acute stress disorder in burn patients by assessing symptoms suggestive of the disorder in patients hospitalized in a burn unit, based on a non-probabilistic convenience sample. The results indicated that the rate of acute stress disorder in patients admitted to the burn unit of the institution studied is close to the prevalence predicted by the Diagnostic and Statistical Manual of Mental Disorders, which is 10%. The research highlights the importance of considering the psychological impacts of burns and the need for public policies to prevent and treat these disorders in affected patients.

Las quemaduras representan un grave problema de salud pública debido a los altos costos financieros y a los impactos físicos, psicológicos y sociales en las personas afectadas. Este artículo presenta un estudio transversal que investigó la posible presencia de trastorno de estrés agudo en pacientes víctimas de quemaduras, mediante la evaluación de síntomas sugestivos del trastorno en pacientes hospitalizados en una unidad de quemados, utilizando una muestra no probabilística y de conveniencia. Los resultados indicaron que la tasa de trastorno de estrés agudo en pacientes ingresados en la unidad de quemados de la institución estudiada se encuentra cercana a la prevalencia prevista en el Manual Diagnóstico y Estadístico de Trastornos Mentales, que es del 10%. La investigación resalta la importancia de considerar los impactos psicológicos de las quemaduras y la necesidad de políticas públicas que puedan contribuir a prevenir y tratar estos trastornos en los pacientes afectados.

Research progress in multi-omics biomarkers involved in post-traumatic stress disorder / 中华创伤杂志

Post-traumatic stress disorder (PTSD) is a psychiatric illness induced by exposure to severe stress-induced traumatic events. Repeated traumatic re-experience, avoidance, negative cognition and emotional changes seriously reduce the quality of life of PTSD patients. Currently, it is urgent to further clarify the etiology and molecular mechanism of PTSD in order to guide the diagnosis and treatment of PTSD. Considering the underlying pathophysiology is not entirely known, to identify the pertinent biomarkers of PTSD is critical in researching its incidence and progression. In contrast with the single-omics researches, multi-omics studies may methodically expand on biomolecular interactions from a range of angles, creating a new potential to comprehend the development of complicated human illnesses. Therefore, the authors review the research progress in PTSD biomarkers from aspects of genomics, transcriptomics and proteomics, hoping to provide a reference for future research and treatment of PTSD.

Relationship of PTSD after hypertensive intracerebral hemorrhage and rs806377 polymorphism of CNR1 gene in elderly patients / 中华老年心脑血管病杂志

Objective To construct a risk prediction model of post-traumatic stress disorder(PTSD)after hypertensive intracerebral hemorrhage in elderly patients and analyze the correla-tion of PTSD with rs806377 polymorphism of cannabinoid receptor 1(CNR1)gene.Methods A total of 215 elderly patients with hypertensive cerebral hemorrhage admitted to the Department of Neurology of Geriatric Hospital of Hainan and Department of Neurosurgery of the First Affiliated Hospital of Hainan Medical University from January 2020 to August 2022 were enrolled in this study.According to the results of PTSD scale(scoring＞50 or 0～50)after surgical treatment,they were divided into PTSD group(43 cases)and non-PTSD group(172 cases).The rs806377 polymorphism of CNR1 gene was detected in both groups by gene sequencing.Univariate and mul-tivariate logistic regression analyses were used to analyze the susceptibility to PTSD among the elderly after hypertensive intracerebral hemorrhage.Another 103 elderly patients with hyperten-sive intracerebral hemorrhage during the same period were also subjected and served as verifica-tion set.A prediction model was constructed.Results There were significant differences in age,family annual income,blood loss amount,psychological resilience score and social support score between the PTSD group and non-PTSD group(P＜0.05,P＜0.01).The PTSD group had obvi-ously larger proportion of TT genotype carriers and higher T allele frequency than the non-PTSD group(P＜0.05,P＜0.01).Logistic regression analysis showed that age(OR=2.020,95％CI:1.115-3.658),family annual income(OR=1.799,95％CI:1.232-2.626),blood loss(OR=1.507,95％CI:1.243-1.826),psychological resilience score(OR=2.059,95％CI:1.068-3.969),social support score(OR=1.664,95％CI:1.122-2.467),rs806377 TT genotype(OR=1.861,95％CI:1.485-2.331)and rs806377 T allele(OR=3.777,95％CI:2.049-6.962)were the influencing fac-tors of postoperative PTSD in these patients(P＜0.05,P＜0.01).ROC curve analysis indicated that the sensitivity was 69.57％,the specificity was 71.25％,and the AUC value was 0.762(95％CI:0.708-0.813)in the verification group,indicating a certain accuracy of our model.Conclusion CNR1 gene rs806377 locus polymorphism is an influencing factor for PTSD susceptibility,and rs806377 TT genotype and rs806377 T allele can predict PTSD in elderly patients after hyperten-sive intracerebral hemorrhage.

Relationship between social support and psychological resilience and post traumatic stress disorder in college students / 中国学校卫生

Objective@#To investigate the characteristics of post traumatic stress disorder (PTSD) in college students during the outbreak of COVID-19, and to explore the mediating role of psychological resilience between social support and PTSD.@*Methods@#By using direct selection method, 572 college students in Anhui and Shanghai were selected and administered with General Characteristics Questionnaire, the PTSD Checklist Civilian Version(PCL-C), Psychological Resilience Scale(PRS) and Social Support Rating Scale(SSRS).@*Results@#Among the participants, 25.0% had moderate PTSD symptoms, 11.7% had obvious PTSD symptoms, and the positive rate of PTSD was 36.7%. The prevalence of PTSD in college students was higher in males than in females ( χ 2= 4.31， P <0.05). The junior students were higher than other students ( χ 2=16.81， P <0.01). The scores of social support, psychological resilience and PTSD were (33.79±4.83), (92.17±13.39) and (35.50±11.39), respectively. The correlations of all variables were statistically significant( r =-0.49-0.76， P <0.05); The mediation test showed that social support could not only negatively predict PTSD directly(direct effect was -0.35), but also indirectly affect PTSD through psychological resilience(indirect effect was -0.32).@*Conclusion@#More than one third of college students have PTSD symptoms, and psychological resilience plays a partial mediating role in the relationship between social support and PTSD,social support can both directly and negatively predict PTSD and indirectly affect PTSD by increasing an individual s psychological resilience.

Research progress in pathogenesis and treatment of post-traumatic stress disorder in patients with traumatic brain injury / 中华创伤杂志

Posttraumatic stress disorder (PTSD), the most common mental illness after patients suffer physically or emotionally from traumatic events, can cause persistently strong, painful and terrible avoidance symptoms, emotional and cognitive changes, causing psychologically strong stimulation and heavy burden to patients and even leading to some extreme behavioral reactions. Traumatic brain injury (TBI) is an important factor in the occurrence of PTSD, both of which shares many similar pathological overlaps, and may coexist and interact with each other. The hippocampus and amygdala play a central role in the pathogenesis of PTSD, but the specific cellular and molecular and neural circuit mechanisms are still unclear. About two-thirds of the patients still meet the diagnostic criteria for PTSD after psychotherapy. However, the current treatment methods are complicated and not unified, and patients treated with medications may have adverse drug reactions, poor treatment outcomes and recurrence. Therefore, it is of great significance to further clarify the occurrence and development of PTSD in TBI patients. The authors reviewed the research progress of the pathogenesis and treatment of PTSD in TBI patients, so as to provide reference for the related research and treatment of PTSD in TBI patients.

La salud humana frente al estrés térmico por el cambio climático

Introducción: La alteración del clima planetario, atribuida directa o indirectamente a la actividad humana, que modifica la composición de la atmósfera mundial y se suma a la variabilidad natural del clima, es conocida como cambio climático global. Sus efectos en la salud, directos e indirectos, ya presentes, perturbarán a la mayoría de las poblaciones en las próximas décadas y pondrán en riesgo la vida y el bienestar de miles de millones de personas. Objetivo: Describir, a partir de una revisión, los principales riesgos para la salud humana derivados de la mayor frecuencia e intensidad de episodios de estrés térmico derivados del cambio climático. Métodos: Se realizó una revisión bibliográfica relativa a los efectos de la temperatura sobre la salud humana, así como su influencia sobre la mortalidad general, en el periodo 2008 hasta 2021, en las bases de datos Scopus, PubMed/Medline, SciELO, Ebsco, LiLACS, así como, otras fuentes y recursos de información disponibles en Internet. Se utilizó el vocabulario controlado del Descriptor en Ciencias de la Salud. Resultados: Se recuperaron 32 publicaciones sobre de la influencia del clima y sus cambios en la salud humana que plantearon, por lo general, que las altas temperaturas guardaron relación con el incremento de la mortalidad principalmente por enfermedades cardiovasculares, cerebrovasculares y respiratorias, se han convertido en un contribuyente considerable a la carga de morbilidad. Conclusiones: Las temperaturas extremas incrementan la morbilidad y mortalidad agudas, principalmente en grupos de riesgo. La promoción de una adecuada hidratación y el uso de ropas adecuadas, ayudará a las personas en la prevención de afecciones por las temperaturas extremas, erigiéndose en acciones individuales de protección contra los efectos de la mayor frecuencia e intensidad de eventos de estrés térmico asociado al cambio climático, a incorporar a la cotidianidad.

Introduction: The alteration of the planetary climate, attributed directly or indirectly to human activity, which modifies the composition of the world atmosphere and adds to the natural variability of the climate, is known as global climate change. Its direct and indirect health effects, already present, will disturb most populations in the coming decades and put the lives and well-being of billions of people at risk. Objective: To describe, based on a review, the main risks to human health derived from the greater frequency and intensity of episodes of thermal stress derived from climate change. Methods: A bibliographic review was carried out regarding the effects of temperature on human health, as well as its influence on general mortality, in the period 2008 to 2021, in the Scopus, PubMed/Medline, SciELO, Ebsco, LiLACS, as well as other information sources and resources available on the Internet. The controlled vocabulary descriptors in Health Sciences were used. Results: 32 publications on the influence of climate and its changes on human health were recovered, which generally stated that high temperatures were related to the increase in mortality, mainly due to cardiovascular, cerebrovascular and respiratory diseases, and have become a significant contributor to the burden of disease. Conclusions: Extreme temperatures increase acute morbidity and mortality, mainly in risk groups. The promotion of adequate hydration and the use of adequate clothing will help people in the prevention of conditions caused by extreme temperatures, establishing individual actions to protect against the effects of the greater frequency and intensity of heat stress events associated with climate change, to incorporate into daily life.

Ninety-day outcomes in patients diagnosed with COVID-19 in São Paulo, Brazil: a cohort study / Desfechos em 90 dias entre pacientes com diagnóstico de COVID-19 em São Paulo (SP): estudo de coorte

ABSTRACT Objective: COVID-19 has been associated with a significant burden to those who survive the acute phase. We aimed to describe the quality of life and symptoms of anxiety, depression, and posttraumatic stress disorder (PTSD) at 90 days after hospital discharge of COVID-19 patients. Methods: Patients with COVID-19 admitted to a private hospital in the city of São Paulo, Brazil, between April of 2020 and April of 2021 were interviewed by telephone at 30 and 90 days after discharge to assess the quality of life and symptoms of depression, anxiety, and PTSD. Results: A total of 2,138 patients were included. The mean age was 58.6 ± 15.8 years, and the median length of hospital stay was 9.0 (5.0-15.8) days. Between the two time points, depression increased from 3.1% to 7.2% (p < 0.001), anxiety increased from 3.2% to 6.2% (p < 0.001), and PTSD increased from 2.3% to 5.0% (p < 0.001). At least one physical symptom related to COVID-19 diagnosis persisted in 32% of patients at day 90. Conclusions: Persistence of physical symptoms was high even at 90 days after discharge. Although the prevalence of symptoms of anxiety, depression, and PTSD was low, these symptoms persisted for three months, with a significant increase between the time points. This finding indicates the need to identify at-risk patients so that they can be given an appropriate referral at discharge.

RESUMO Objetivo: A COVID-19 tem sido associada a um fardo significativo para aqueles que sobrevivem à fase aguda. Nosso objetivo foi descrever a qualidade de vida e sintomas de ansiedade, depressão e transtorno de estresse pós-traumático (TEPT) 90 dias após a alta hospitalar em pacientes com COVID-19. Métodos: Pacientes com COVID-19 internados em um hospital privado na cidade de São Paulo (SP) entre abril de 2020 e abril de 2021 foram entrevistados por telefone 30 e 90 dias após a alta para avaliar a qualidade de vida e sintomas de depressão, ansiedade e TEPT. Resultados: Foram incluídos 2.138 pacientes. A média de idade foi de 58,6 ± 15,8 anos, e a mediana do tempo de internação hospitalar foi de 9,0 (5,0-15,8) dias. Entre os dois momentos, a depressão aumentou de 3,1% para 7,2% (p < 0,001), a ansiedade, de 3,2% para 6,2% (p < 0,001), e o TEPT, de 2,3% para 5,0% (p < 0,001). Pelo menos um sintoma físico relacionado ao diagnóstico de COVID-19 persistia em 32% dos pacientes no 90º dia. Conclusões: A persistência dos sintomas físicos foi elevada mesmo 90 dias após a alta. Embora a prevalência de sintomas de ansiedade, depressão e TEPT tenha sido baixa, esses sintomas persistiram por três meses, com aumento significativo entre os momentos. Esse achado indica a necessidade de identificar os pacientes de risco para que possam receber o encaminhamento adequado no momento da alta.

Adaptación y validación del Cuestionario de Trastorno de Estrés Postraumático (COVID-19-PTSD) en población peruana / Adaptation and Validation of the Questionnaire on Posttraumatic Stress Disorder in a Peruvian Population

Introducción: La alta prevalencia de trastornos mentales como el estrés, en situaciones estresantes prolongadas inducidas por una pandemia, demanda su detección y valoración oportuna; para ello se requieren instrumentos contextualizados y con adecuadas propiedades métricas. Objetivo: Validar el Cuestionario sobre el Trastorno de Estrés Postraumático y Prevalencia de Sintomatología de Estrés Postraumático en población peruana. Métodos: Estudio de tipo instrumental, realizado en la región Ica del Perú, de junio a noviembre del 2021, en 412 participantes adultos. El proceso incluyó traducción al español, evaluación del contenido por jueces y prueba piloto. La validez de constructo se evaluó mediante el Análisis Factorial Exploratorio y el ajuste con Análisis Factorial Confirmatorio, que incluyó el Método de Estimación de Mínimos Cuadrados no Ponderados Robustos; se evaluó la confiabilidad con el Omega de McDonald y comparó la sintomatología del trastorno de estrés postraumático con variables generales. Resultados: Se obtuvo una versión de dieciocho ítems, agrupados en cuatro factores que explicaron el 70,78 por ciento de la varianza total y un ajuste aceptable [x2/gl = 1,54; NFI y CFI = 0,99; SRMR = 0,052; RMSEA = 0,036 (IC90 por ciento: 0,26-0,46)]. Los ítems discriminan de forma satisfactoria; así como la escala según variable sexo, estado civil y los que tienen familiar fallecido por COVID-19. La consistencia interna fue adecuada para la escala global (ω = 0,924) y sus dimensiones (EDA = 0,740; IEAN = 0,882; A = 0,786 y CE = 0,811). Conclusión: La nueva versión peruana del instrumento posee propiedades métricas aceptables; por tanto, se recomienda su uso para valorar el trastorno de estrés postraumático y estudios de validación(AU)

Introduction: The high prevalence of mental disorders such as stress, in prolonged stressful situations induced by a pandemic, demands their timely identification and assessment; in order to do this, contextualized instruments with adequate metric properties are required. Objective: To validate the Questionnaire on Posttraumatic Stress Disorder and Prevalence of Posttraumatic Stress Symptomatology in a Peruvian population. Methods: An instrumental study was conducted in the region of Ica, in Peru, from June to November 2021, with 412 adult participants. The process included translation into Spanish, content assessment by judges, and pilot testing. Construct validity was evaluated by exploratory factor analysis; and fit, with confirmatory factor analysis, which included the robust unweighted least squares estimation method. Reliability was evaluated with McDonald's Omega, while the posttraumatic stress disorder symptomatology was compared with general variables. Results: The obtained version included 18 items, grouped into four factors that explained 70.78 percent of the total variance. Also, an acceptable fit was obtained [x2/gl=1.54; NFI and CFI=0.99; SRMR=0.052; RMSEA=0.036 (90 percent CI: 0.26-0.46)]. The items discriminate satisfactorily, as does the scale according to sex, marital status and those with a family member who died from COVID-19. Internal consistency was adequate for the global scale (ω = 0.924) and its dimensions (EDA=0.740; IEAN = 0.882; A=0.786 and CE=0.811). Conclusion: The new Peruvian version of the instrument has acceptable metric properties; therefore, its use is recommended for assessing posttraumatic stress disorder and validation studies(AU)

Pandemia da Covid-19: um evento traumático para estudantes de Ciências Biológicas e da Saúde? / The Covid-19 pandemic: a traumatic event for health and biological science students?

Resumo: Introdução: Os universitários de Ciências da Saúde se tornaram especialmente afetados pela pandemia do vírus Sars-CoV-2. As angústias intrinsicamente relacionadas à Covid-19 foram somadas aos impactos referentes às mudanças acontecidas nas instituições acadêmicas, particularmente a mudança para o ensino on-line, uma metodologia que pode gerar desconforto aos estudantes, além de vários obstáculos relacionados ao ensino e à aprendizagem, o que pode ter repercussões traumáticas importantes na saúde mental dessa população. Objetivo: Este estudo teve como objetivo verificar a carga mental provocada pela pandemia da Covid-19, como um evento traumático ao ponto de desencadear transtornos psiquiátricos, como o transtorno do estresse pós-traumático (Tept), em universitários. Método: Trata-se de um estudo transversal e quantitativo, com orientação analítico-descritiva, mediante preenchimento de formulário digital anônimo, iniciado após prévia aprovação do Comitê de Ética em Pesquisa. Os sujeitos foram estudantes de Ciências Biológicas e da Saúde de uma universidade estadual localizada na Região Sudeste do Brasil. A amostra foi constituída por 618 estudantes. Resultado: Foram respondidos 618 formulários pelos estudantes que pertenciam aos cursos de Educação Física (28,8%), Medicina (25,4%), Odontologia (18,1%), Ciências Biológicas (15,2%) e Enfermagem (12,5%). A presença de sintomas de estresse pós-traumático verificados pela Escala de Impacto do Evento-Revisada (IES-R) obteve prevalência de 32,7% (n = 202) entre os estudantes universitários das Ciências Biológicas e da Saúde. Conclusão: Houve impacto significativo na saúde mental dos universitários com presença de sintomas depressivos, ansiedade e estresse acima dos encontrados na literatura científica, e, consequentemente, constatou-se alta na prevalência do Tept.

Abstract: Introduction: Health Sciences university students were especially affected by the Sars-CoV-2 virus pandemic. The anxieties intrinsically related to Covid-19 were added to the impacts related to the changes that have taken place in academic institutions, particularly the change to online teaching, a methodology that can generate discomfort for students, in addition to several obstacles related to teaching and learning, which can have important traumatic effects on the mental health of this population. Objective: To assess the mental health burden caused by the COVID-19 pandemic, as a traumatic event capable of triggering psychiatric disorders, such as Post-Traumatic Stress Disorder (PTSD), in university students. Methods: This is a cross-sectional and quantitative study, of analytical-descriptive nature, carried out by filling out an anonymous digital form, initiated after prior approval by the Research Ethics Committee. The subjects were students of Biological and Health Sciences at a State University located in the southeastern region of Brazil. The sample consisted of 618 students. Results: 618 forms were answered by students attending the courses of Physical Education (28.8%), Medicine (25.4%), Dentistry (18.1%), Biological Sciences (15.2%) and Nursing (12.5%). The presence of post-traumatic stress symptoms assessed by the Impact of Event Scale - Revised (IES-R) obtained a prevalence of 32.7% (n = 202) among university students from Biological and Health Sciences courses. Conclusions: There was a significant impact on the mental health of university students, with the presence of depressive symptoms, anxiety and stress above those found in the scientific literature and, consequently, a high prevalence of PTSD.

Symptoms of post-traumatic stress disorder and affects in healthcare workers during the COVID-19 pandemic / Sintomas de transtorno de estresse pós-traumático e afetos em profissionais da saúde durante a pandemia da COVID-19

Objective: This study aimed to evaluate symptoms of post-traumatic stress disorder and affects in health professionals during the COVID-19 pandemic. Method: Three hundred and seventy-four health professionals, among which 235 were front-line and 139 non-front-line workers, answered an online questionnaire consisting of socio-demographic data, identification of past mental disorders, personal experience facing the pandemic, the Impact of Event Scale, and the Positive and Negative Affect Schedule. The sample consisted mainly of physicians and nursing staff aged between 30 and 49 years. Results: The results demonstrate high scores of symptoms related to post-traumatic stress disorder, with greater expressiveness among front-line professionals, especially in the nursing staff, and a strong correlation of these results with negative affects. Conclusion: Psychological assistance and interventions directed to health professionals are urgent to mitigate the impacts caused by the COVID-19 pandemic.

Objetivo: Este estudo objetivou avaliar sintomas de transtorno de estresse pós-traumático e afetos em profissionais de saúde durante a pandemia da COVID-19. Método: Trezentos e setenta e quatro profissionais da área da saúde, dentre os quais 235 profissionais que estavam atuando na linha de frente e 139 que não estavam na linha de frente, responderam a um questionário online composto por dados sociodemográficos, identificação de transtornos mentais pregressos, experiência pessoal frente à pandemia e Escala do Impacto do Evento e Escala de Afetos Positivos e Afetos Negativos. A amostra foi composta majoritariamente de médicos e funcionários da equipe de enfermagem com idades entre 30 e 49 anos. Resultados: Os resultados demonstram altas pontuações de sintomas relativos ao transtorno de estresse pós-traumático, com maior expressividade nos profissionais da linha de frente, principalmente na equipe de enfermagem, e forte correlação desses resultados com afetos negativos. Conclusão: O atendimento e intervenções psicológicas direcionadas aos profissionais de saúde são urgentes para mitigar os impactos causados pela pandemia da COVID-19.

Fatores associados ao transtorno de estresse pós-traumático e sua relação sobre a qualidade de vida em mulheres com queimadura profunda / Factors associated with post-traumatic stress disorder and their relationship on quality of life in women with deep burns

OBJETIVOS: Determinar os fatores associados ao transtorno de estresse pós-traumático (TEPT) e verificar a correlação com a qualidade de vida (QV) em mulheres com queimaduras profundas. MÉTODO: Estudo de corte transversal, realizado em um hospital de referência para queimados na Região Nordeste do Brasil. Foram incluídas 50 mulheres adultas com mais de 20 anos, que sofreram queimaduras profundas e estavam em tratamento ambulatorial de reabilitação. Foram aplicados os questionários das variáveis sociodemográficas e clínicas e instrumentos para verificar a QV, Burn Specific Health Scale-Revised-BSHS-R, e o TEPT, o Impact of Event Scale-IES. Para análise estatística, foi usado o teste t de Student e também os modelos de regressão linear simples e múltipla. RESULTADOS: Observou-se uma média do escore IES menor estatisticamente quando o índice de massa corporal < 30kg/m2 e maior quando a renda familiar mensal <1 salário-mínimo, o tempo de fisioterapia < 6 meses e diante da necessidade de utilização de órtese. Exceto o domínio de habilidades funcionais simples do questionário BSHS-R, para os demais domínios, incluindo o somatório total, encontrou-se uma correlação positiva entre os escore do IES e do BSHS-R. CONCLUSÕES: Obesidade, baixa renda familiar, menor tempo de fisioterapia e necessidade de uso de órtese, além da pior qualidade de vida, foram os fatores associados ao TEPT em mulheres com queimaduras profundas, sugerindo necessidade de políticas públicas específicas para essa população.

OBJECTIVES: To determine factors associated with post-traumatic stress disorder (PTSD) and actively check with quality of life (QoL) in women with deep burns. METHODS: Cross-sectional study, carried out in a reference hospital for burns in the northeast region of Brazil. Fifty adult women over 20 years old who had suffered deep burns and were undergoing outpatient rehabilitation treatment were included. The experimental variables of sociodemographic and clinical variables and instruments were applied to verify QoL, Burn Specific Health Scale-Revised-BSHS-R, and PTSD, Impact of Event Scale-IES. For statistical analysis, Students t test was used, as well as simple and multiple linear regression models. RESULTS: A statistically lower average IES score was observed when the body mass index < 30kg/m2 and higher when the monthly family income < 1 minimum wage, the time of physiotherapy < 6 months and in view of the need to use an orthosis. Except for the simple skills domain of the BSHS-R, for the other domains, including the total sum, a positive correlation was found between the IES and BSHS-R scores. CONCLUSIONS: Obesity, low family income, shorter physiotherapy time and the need to use an orthosis, in addition to a worse quality of life, were factors associated with PTSD in women with deep burns, suggesting the need for specific public policies for this population.

Estresse, coping e estados afetivos em profissionais da saúde durante a pandemia / Distress, coping and affective statesin healthcare workers durig the COVID-19 pandemic / Estrés, afrontamiento y estados afectivos em profissionales de la salud durante la pandemia de COVID-19

A pandemia da COVID-19 configurou um período de crise mundial com impactos na saúde mental de toda a população, notadamente dos profissionais de saúde da linha de frente. Objetivou-se rastrear a presença de sintomas de Transtorno de Estresse Pós-Traumático em profissionais de saúde da linha de frente e verificar sua associação com estratégias de coping e estados afetivos durante a pandemia da COVID-19 no Brasil. Realizou-se um estudo longitudinal on-line com 51 profissionais da saúde da linha de frente residentes nas cinco regiões do Brasil que responderam aos instrumentos: Escala do Impacto do Evento, Escala de Afetos Positivos e Afetos Negativos, Escala de Coping Ocupacional e questionário sobre a experiência pessoal frente à pandemia. Por meio de análises de comparação de proporções e médias, bem como análise de correlações, verificou-se alto índice de sintomas relacionados ao Transtorno de Estresse Pós-Traumático nos três momentos de coleta com correlações significativas com afetos negativos, mas não com estratégias de coping. Destaca-se o risco aumentado para o desenvolvimento ou agravo de transtornos mentais nesses profissionais, particularmente quadros de estresse pós-traumático e dificuldades de regulação emocional, que exigem ações urgentes de cuidado psicológico (AU).

The COVID-19 pandemic forgeda period of global crisis with impacts on the mental health of the entire population, notably frontline health professionals.The study aimed to track the presence of Post-Traumatic Stress Disorder symptoms in frontline healthcare workers and verify its association with coping strategies and affective states during the COVID-19 pandemic in Brazil. A longitudinal onlinestudy was carried out with 51 frontline healthcare professionalsfrom the fiveregions of Brazilwho responded to the following instruments: Impact of Event Scale, Positive Affect and Negative Affect Scale, Occupational Coping Scale, and questionnaire about personal experience during the pandemic. Comparison of proportions and means, as well as correlationanalysis,revealeda high rate of symptoms related to Post-Traumatic Stress Disorder in the three point of data collection, with significant correlations with negative affects, but not with coping strategies. The increased risk for the development or worsening of mental disorders in these professionals is highlighted, particularly post-traumatic stress and emotional regulation difficulties, which require urgent psychological care actions (AU).

La pandemia de COVID-19 estableció un período de crisis global con impactos en la salud mental de toda la población, en particular de los profesionales de la salud de primera línea. El objetivo fue rastrear la presencia de síntomas de Trastorno de Estrés Postraumático en profesionales de salud de primera línea y verificar su asociación con estrategias de afrontamiento y estados afectivos durante la pandemia de COVID-19 en Brasil. Se realizó un estudio longitudinal onlinecon 51 profesionales de salud de primera línea residentes de las cincoregiones de Brasil que respondieron los siguientes instrumentos: Escala de Impacto de Evento, Escala de Afectos Positivos y Negativos, Escala de Afrontamiento Ocupacional y cuestionario sobre experiencia personal frente ala pandemia.Los análisisde comparación de proporciones y medias, así como análisis de correlaciones, mostró una alta tasa de síntomas relacionados con el Trastorno de Estrés Postraumático en los tres momentos de recolección de datos, con correlaciones significativas con los afectos negativos, pero no con las estrategias de afrontamiento. Se destaca el mayor riesgo para el desarrollo o empeoramiento de trastornos mentales en estos profesionales, en particular el estrés postraumático y las dificultades (AU).