RESUMEN
Objective To study the phenylpropanoids from the roots of Datura metel. Methods The separations and purifications were taken by silica gel and ODS chromatogram columns as well as preparative HPLC, and the structural identification based on physicochemical property, 1H-NMR and 13C-NMR as well as HR-MS data. Results Nineteen compounds obtained from the butanol fraction of the 70% ethanol extract of D. metel roots, which were identified as icariside E5 (1), alangisesquin A (2), Glycopentoside F (3), conicaoside (4), (7S,8R) dehydrodiconiferyl alcohol 9’-O-β-glucopyranoside (5), iariciresinol-4’-O-β-D-glucopyranoside (6), 7R,8R-threo-4,7,9-trihy-droxy-3,3’-dimethoxy-8-O-4’-neolignan-9’-O-β-D-glucopyranoside (7), vitrifol A (8), leptolepisol D (9), thero-2,3-bis-(4-hydroxy-3-methoxypheyl)-3-methoxy-propanol (10), hyuganoside IIIb (11), officinalioside (12), iariciresinol-9-O- β-D-glucopyranoside (13), stroside A (14), erythro-buddlenol B (15), sargentodoside D (16), (+)-(7S,8S)-4-hydroxy-3,3’,5’- trimethoxy-8’,9’-dinor-8,4’-oxyneolignan-7,9-diol-7’-oic acid (17), 5’-methoxy lariciresinol (18), and dehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (19). Conclusion Compounds 2-19 are isolated from Solanaceae family for the first time and compound 1 is firstly isolated from genus Datura L.