A Case of Superficial Spreading Capillary Hemangioma / 대한피부과학회지

No abstract available.

Carcinoma epidermoide de cuello uterino con extensión superficial a endometrio / Squamous cell carcinoma of the cervix with superficial extension to the endometrium

El cáncer de cuello uterino es la neoplasia más frecuente del tracto genital femenino, que en su forma avanzada puede invadir localmente a tejido paracervical, vagina, vejiga y recto. Se presenta un caso, muy poco frecuente, de carcinoma cervical con extensión endometrial como neoplasia in situ, en una paciente de 76 años y que se manifestó clínicamente como piometra.

Cervical cancer is the most common malignant tumor of the female genital tract, which in its advanced stage can invade locally paracervical tissue, vagina, bladder and rectum. A case extremely rarely is reported of cervical carcinoma with in situ carcinoma involving to endometrium in a patient of 76 years old and clinically manifested as pyometra.

Características clínicas e histopatológicas del melanoma maligno en el Hospital General Dr. Manuel Gea González / Clinical and histopathological characteristics of malignant melanoma cases seen at Dr. Manuel Gea González General Hospital

Antecedentes: El melanoma maligno es una neoplasia derivada de los melanocitos que suelen localizarse en la unión dermoepidérmica. A pesar de que su incidencia es baja, menor de 10%, 75% de las muertes por cáncer cutáneo se debe a esta neoplasia. Existen cuatro variantes: de extensión superficial, léntigo melanoma maligno, acral lentiginoso y nodular. En la población caucásica predomina el melanoma de extensión superficial; en series mexicanas se ha encontrado que prevalece el nodular. El objetivo de este estudio fue describir los casos de melanoma maligno del Hospital General “Dr. Manuel Gea González” para establecer la frecuencia de presentación y el subtipo clínico. Métodos: Se realizó estudio retrospectivo, descriptivo y transversal, de marzo de 1981 a diciembre del 2006, de los pacientes con melanoma; se registró sexo, edad, residencia, ocupación, evolución de la lesión, topografía y manifestaciones clínicas. Histológicamente se valoró el índice de Breslow y el nivel de Clark. Resultados: Se incluyeron 165 pacientes, de los cuales 112 fueron del sexo femenino y 53 del masculino. La localización más frecuente fue la extremidad inferior. El melanoma acral lentiginoso fue el que mostró mayor prevalencia. Conclusiones: En esta serie los subtipos con mayor prevalencia fueron el melanoma acral lentiginoso y el léntigo maligno melanoma, a diferencia de otras series donde se informa el nodular y el de extensión superficial. La proporción mujer:hombre fue de 2.1:1, mayor a la indicada en otras series.

BACKGROUND: Melanoma is a type of tumor that arises from melanocytes generally located in the dermoepidermal junction. Although melanoma is found in less than 10% of cases, mortality is high representing 75% of deaths attributed to cutaneous cancer. There are four major subtypes: Superficial spreading melanoma, lentigo malignant melanoma, acral lentiginous melanoma and nodular melanoma. Superficial spreading melanoma is the most common type among Caucasians. In a Mexican case series, the nodular type is the most common type reported. The aim of this study was to determine the most common type seen at our medical facility. METHODS: We analyzed patient's medical records from March 1981 to December 2006. Demographic data included sex, age, place of residence, occupation, tumor progression, location and clinical description. Histologically we evaluated tumor thickness using the Breslow scale; invasion was measured using the Clark scale. This is a descriptive, cross-sectional and retrospective study. RESULTS: 165 patients were studied, 112 were females and 53 males. The most common location was the lower limb. Acral lentiginous melanoma was the most common subtype. CONCLUSIONS: Our findings differ from the other series where they report nodular and superficial spreading melanoma as the most common types. The most common subtypes in our study were acral lentiginous melanoma and lentigo malignant melanoma among females, with a ratio of female-male of 2.1:1.

Clinicopathologic Features of the Superficial Spreading Type of Early Gastric Cancer

PURPOSE: The superficial spreading type of early gastric cancer (SSE) has unique features such as its growth pattern and histologic aggressiveness. But its incidence rate is very low, so the clinicopathologic features of SSE are not well known. The aim of this study is to clarify the clinicopathologic features of the superficial spreading type of gastric cancer and we propose an appropriate treatment strategy with the proper treatment modality. METHODS: A retrospective study was conducted on 894 surgically resected patients with early gastric cancer. The superficial spreading type was defined as a lesion more than 20 cm(2). The demographic features and histopathological features were analyzed by using the hospital records. The survival rate was analyzed by the Kaplan-Meier method and the other statistics were analyzed using the chi-square test. RESULTS: For the superficial and common groups, there were no significant differences in the rates of submucosal layer invasion, the histologic types and differentiation and the tumor location. But the ratio of lymph node metastasis was significantly different (P<0.05). There were some differences concerning the operative methods between the groups. For the superficial spreading type, the portion of total gastrectomy was greater than that of the common type. The average distance between the upper portion of the tumor and the proximal resection margin was shorter for the superficial spreading type than that for the common type (3.78+/-2.79 cm vs 5.58+/-2.79 cm, respectively). The 5 year survival rate and the recurrence rate between the two types were not significantly different. CONCLUSION: Because of the higher rate of lymph node metastasis and the higher rate of an indistinct tumor margin, wide resection with adequate lymph node dissection (D1+beta or more) seems to be a proper operative method for the superficial spreading type of early gastric cancer.

A Case of Melanoma Arising from Acquired Nevus / 대한피부과학회지

Malignant melanoma is a tumor arising from melanocytes which originate in the neural crest. According to several reports, about 20-30% of all melanoma are associated with pre-existing nevi. Because early detection and intervention of aquired and congenital nevi is the only way to increase survival, the important risk factors should be carefully observed, especially if there are changes of to the number, size, and characteristic of the nevi. We present a 41 year-old man who has a superficial, spreading type of malignant melanoma, which arose from an acquired nevus following trauma to the right malleolar area. This case is interesting because of the clinical type and accompanying pathologic condition of the benign nevus.

Clinicopathological Analysis of a Superficial Spreading Type of Early Gastric Cancer

PUPOSE: The superficial spreading type of early gastric cancer has different clinicopathologic features from other types of early gastric cancer in terms of its invasiveness and lymph-node metastases. Therefore, we attempted to elucidate the pathological features, surgical procedures and patients prognoses. MATERIALS AND METHODS: Clinical information was reviewed for patients who had undergone a gastrectomy for gastric cancer during an 8-year period (1995~2002) at Dankook University Hospital and Ulsan University, with an average follow-up of 48 months. Three hundred (300) superficial spreading lesions were analyzed with respect to macroscopic type, lymph-node (LN) metastasis, recurrent pattern, survival rate and method of surgical operation. In addition, the clinicopathological features of the superficial spreading type were compared with those of 739 other patients with small-sized cancer. RESULTS: In both groups, the IIc-type macroscopic lesion, the elevated subtype to be more specific, occurred most frequently. There was no significant difference in the method of surgery between the groups. The submucosal invasion was 39.8% in small-sized cancer, and 61.7% in superficial spreading cancer (P=0.005). The incidence of LN metastasis was 11.3% in early gastric cancer, 7.8% in small-sized cancer and 20.0% in superficial spreading cancer (P=0.005). The incidence of lymphatic invasion was 4.6% in small-sized cancer and 13.0% in superficial spreading cancer (P=0.009). The incidence of recurrence was 1.4% in small-sized cancer and 3.6% in superficial spreading cancer. The overall 5-year survival rate was 84.8% in superficial spreading cancer and 93.0% in small-sized cancer (P=0.052). The 5-year disease- free survival rate was 94.7% in superficial spreading cancer and 87.5% in small-sized cancer (P=0.053). CONCLUSION: The superficial spreading type of early gastric cancer tends to be more invasive and to show a higher incidence of lymph-node metastasis than small-sized early gastric cancer. A wide resection with extensive lymph-node dissection seems to be an appropriate treatment for a superficial spreading type of early gastric cancer.

Clinicopathological Analysis of Superficial Spreading and Small-sized Types of Early Gastric Cancer

PURPOSE: The superficial spreading type of early gastric cancer has different clinicopathologic features from other types of early gastric cancers in terms of its invasiveness and lymph node metastases. Therefore, the clinicopathological features of the superficial spreading type and the small-sized early gastric cancers, were analyzed, and the influence of those features on the surgical procedures and prognosis was investigated. METHODS: During an 8-year period (1992~1999), 22 superficial spreading early gastric cancers were analyzed with respect to the macroscopic type, lymph node metas tasis, and the surgical procedure, and compared with those of 219 small-sized early gastric cancers. The superficial spreading type was defined as a lesion more than 5 5 cm and small-sized type, as a lesion less than 2 2 cm. The survival rate was analyzed using the Kaplan-Meier method and those patients who died of diseases unrelated to gastric cancer were excluded. Other statistical analyses were performed using the chi-square test. RESULTS: Twenty two out of 369 (6%) early gastric cancers were the superficial spreading type. The incidence of a LN metastasis was 12.3% in early gastric cancer, 8.7% in the small-sized type, and 27.3% in the superficial spreading type. The incidence of a LN metastasis was greater in the superficial spreading type than in the small-sized type (P=0.006). The location of the lesions, the histological type, and the depth of the invasion in the superficial spreading and small-sized early gastric cancers were similar There was difference in the method of surgery and the extent of the lymph node dissection between two groups. CONCLUSION: Because the incidence of a lymph node meta stasis is higher in the superficial spreading type than in the small-sized early gastric cancer, a wide resection with an extensive lymph node dissection appears to be appropriate treatment for the superficial spreading type of early gastric cancer.

Superficial Spreading Stomach Cancer: Report of One Case / 대한소화기내시경학회지

Superficial spreading stomach cancer, as first described by Stout in 1942, is superficially spreading cancer confined to mucosa and submucosa, and measuring up to 10 cm in diameter. Clinical manifestation is peptic ulcer like symptom with a long duration, and a gross appearance is characterized by reddening, irregular and slight nodular thickening of the involved mucosa. We should be careful to differentiate chronic atrophie gastritis or multiple superficial gastric erosions from superficial spreading stomach cancer. It is classified to a subtype of early gastric cancer type Ilc(IIc'') and the prognosis is as good as early gastric cancer. A 60-yearold woman was admitted to our hospital because of epigastric pain for 2 years. She was confirmed to have superficial spreading stomach cancer by gastroduodenoscopy, endoseopic ultrasonography, and operation. We report a case of superficial spreading stomach cancer with a review of relevant literatures.