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Introduction: Blood pressure (BP) control continues to be important in reducing cardiovascular risk, along with the modification of other cardiovascular risk factors, especially cholesterol level. Lifestyle modification to reduce BP may control Stage 1 hypertension. Drug treatment should be based on evidence of improved outcomes and individualized account for the patient age, race, and quality of life. BP varies from minute to minute and is influenced by measurement technique, time of day, emotion, pain, discomfort, hydration, temperature, exercise, posture, and drugs. Purpose of Review: In this review, we examine how synthetic novel drugs involved in the management of hypertension not only in the wider population but also within special population groups such as the elderly, pregnant women, and those with a trial fibrillation. Conclusion: The extensive synthetic work carried out shows that some molecules are very effectively managing the hypertension in all ages of patients. Summary: We have made an attempt in reviewing the literature on 1,2 pyrazoline derivatives for their medicinal uses with the help of chemical abstract, journals, and internet surfing.
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A pesquisa teve como objetivo avaliar os atributos de qualidade e de durabilidade dos ovos de duas diferentes linhagens de poedeiras, com dietas contendo aditivos artificiais ou naturais, em diferentes períodos de armazenamento. Foram quantificadas durante o armazenamento as variáveis perda de peso, pH da gema e albúmen, gravidade específica, índice de gema (IG) e foi realizada também classificação por peso e Unidade Haugh (UH). Os resultados foram avaliados segundo teste de Tukey (P≤0,05). As linhagens diferiram quanto à classificação extra dos ovos, com maior porcentagem para a Isa Brown. Os ovos obtidos das poedeiras Carijó apresentaram maior porcentagem de gema (Carijó 30,66 e Isa-Brown 24,55). O tempo de armazenamento fez com que a porcentagem de gema aumentasse nas duas linhagens (Carijó 30,66 tempo zero para 34,85 depois de 36 dias; e Isa- Brown de 24,55 para 27,48). As dietas com aditivos artificiais ou naturais não influenciaram a porcentagem de clara ( por cento Clara 58,72 Controle; 59,52 Aditivo; 60,11 Urucum 1,5 por cento; 59,43 e de gema por centoGema 27,64 Controle; 27,90 Aditivo; 27,21 Urucum 1,5 por cento; 27,66 Urucum 2 por cento). O pH da clara diferiu entre os tratamentos no tempo inicial e aos 36 dias de armazenamento, mas o pH da gema não diferiu durante todo o armazenamento. O índice de gema diferiu nos tempos de armazenamento, mas não diferiu considerando os tratamentos. Em dietas com aditivos artificiais ou naturais, as linhagens e os tempos de armazenamento influenciam na qualidade e durabilidade dos ovos.
The research has the aim of evaluating quality and durability attributes of eggs from two hens lines feed with and without natural or synthetics additives, at several storage periods. During storage, weight lost, albumen and yolk pH, specific gravity andyolk index (IG) were quantified , as well as, weight classification and Haugh Unit (HU) The results were analyzed by Tukey test (P≤0.05). Quality differences are bigger by lines and storage time and the extra classification of eggs were higher for Isa Brown. The egg of Carijó hens presented more yolk percentage (Carijó 30.66 e Isa-Brown 24.55). The storage higher increased yolk percentage (Carijó 30.66 time zero for 34.85 after 36 days; and Isa- Brown 24.55 for 27.48). Two lines diets with natural or synthetics additives didn't influence the white and yolk percentage ( percentwhite 58.72 Control; 59.52 Aditive; 60.11 Urucum 1.5 percent; 59.43 e de yolk and 27.64 Control; 27.90 Aditive; 27.21 Urucum 1.5 percent; 27.66 Urucum 2 percent). Clear pH differs among treatments at initial time and at 36 days of storage, but the yolk pH didn't chage during all storage. The yolk index differed in the storage time, but not at treatments. So, it's possible to concluded that diets with natural and synthetics additives, lines and storage times had influenced quality and durability attributes in the eggs.
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A partir da década de 1980, o misoprostol inicialmente usado em Gastroenterologia, logo foi adotado para uso obstétrico, tanto legal quanto ilegal. De droga vista com desconfiança inicialmente, tornou-se método de escolha nos melhores centros obstétricos. Este estudo teve como objetivo uma atualização do uso do misoprostol para a indução do parto de feto vivo nas várias vias e formas de aplicação. Foi feita uma avaliação das várias vias de aplicação e as dosagens recomendadas pelos autores referendados, com análise crítica da sua efetividade. Conclui-se pela efetividade e segurança do método, ser no momento o método recomendado pelo Ministério da Saúde e pela Federação Brasileira das Associações de Ginecologia e Obstetrícia.
From the 1980s, misoprostol used initially in Gastroenterology, was soon adopted for obstetrics use, legal or illegal. It was considered an unbelieved drug at the begining, but now is the first choice in the best obstetric centers. The purpose of this study was to update the misoprostol use in labor induction with live fetus, at several ways and administration forms. An evaluation of the several administration ways and of the recommended doses by referenced authors was done, with critical analysis of its efficacy. By the method's effectiveness and security it was concluded that the misoprostol is recommended to labor induction for the Brazylian Health Minister, and the Brazilian Federation of Gynecology and Obstetrics.