RESUMEN
Background: TKTL1 is expressed in various tumor tissues, and its expression level is closely related to tumor invasion, metastasis and prognosis. Aims: To investigate the expression and clinical significance of TKTL1 in colon adenoma and colon cancer. Methods: Thirty normal colon mucosa, 84 colon adenoma confirmed by colonoscopy, and 84 colon cancer tissues diagnosed by surgery from March 2015 to May 2018 at the First Hospital of Zibo were enrolled. Protein expression of TKTL1 was detected by immunohistochemistry, and its relationship with clinicopathological parameters in patients with colon adenoma, colon cancer were analyzed. Results: Rate of TKTL1 expression was significantly increased in colon adenoma and colon cancer than in normal colon mucosa (57.1%, 85.7% vs. 13.3%, P0.05). The expression of TKTL1 was not related to gender, age, differentiation in patients with colon cancer (P>0.05), while was related to TNM staging, distant metastasis, lymph node metastasis and depth of infiltration (P<0.05). Conclusions: The expression of TKTL1 in colon adenoma and colon cancer is significantly higher than that in normal colon tissues, and is related to the staging and metastasis of colon cancer. The expression of TKTL1 is closely related to the occurrence and development of colon cancer.
RESUMEN
Up to now,one transketolase (TKT) and two transketolase-like genes (TKTL1 and TKTL2) have been identified in the human genome.People have conducted a series of basic and clinical researches of TKTL1 in malignant neoplasms since Coy found TKTL1 has a high expression of protein and gene levels in the malignant tumors in 2005.Although the biochemical and functional mechanism have not been clarified clearly,a positive role of TKTL1 in promoting tumorigenesis and tumor progression has been proved.