Analysis of occupational health examination results of radiation workers in medical institutions of Shenzhen in 2020 / 中国辐射卫生

Objective To analyze the medical examinations of radiation worker in medical institutions and provide some basic data for radiation protection management. Methods The occupational health examination of 3568 radiation workers from 681 medical institutions who came to our hospital for occupational health examination from January 1 to December 31 in 2020 were summarized and analyzed. Results There was no case of suspected occupational radiation sickness. The abnormal rate was in the range of 2.17%～2.99%, the rate of occupational contraindicated was about 1.44%～2.17%. The total review rate was about 13.00%, more than 79.48% of the radiation workers were checked out other diseases or abnormal. The abnormal examination items are mainly ophthalmology, B ultrasound of liver, gallbladder, spleen and pancreas, liver function, electrocardiogram, blood routine, urine routine, blood pressure, B ultrasound of both kidneys and kidney function. The abnormal rate of ophthalmology in each level of institutions was decreased with the increase of the length of service, while the abnormal results of B-ultrasound of liver, gallbladder, spleen and pancreas, blood pressure, B-ultrasound of both kidneys and renal function were increased with the increase of service. Conclusion Maybe the radiation protection of radiation workers in medical institutions was well in Shenzhen, but there were different effects of the health status of the staff. Therefore, it is important to further strengthen the occupational health monitoring management.

Mechanism of Gardenia jasminoides against cholestasis based on network pharmacology / 中国中药杂志

To screen the active ingredients of Gardenia jasminoides and potential targets,and investigate the mechanisms against cholestasis based on network pharmacology technology. Twenty-one active components of G. jasminoides were retrieved and the target sites were screened by using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform( TCMSP). Cytoscape3. 2. 1 was used to construct the component-target network. Two hundred and eight targets related to cholestasis were searched and screened through Dis Ge NET,KEGG and OMIM databases. The key targets of G. jasminoides components and cholestasis were integrated and screened,and the component-target-disease network was constructed with Cytoscape 3. 2. 1 software to screen out the core network whose freedom degree was greater than the average value. The Clue GO plug-in of Cytoscape 3. 2. 1 software was used to analyze the biological processes and pathway enrichment of G. jasminoides in regulation of cholestasis. GO biological process analysis revealed 17 biological processes,involving 3 signaling biological processes related to cholestasis,i.e. acute inflammatory response,positive regulation of reactive oxygen species metabolic process,and nitric oxide biosynthetic process. KEGG-KEEG-305 terms and REACTOME pathways analysis revealed 17 regulatory pathways,involving 4 signaling pathways related to cholestasis,i.e. metabolism of xenobiotics by cytochrome P450,nuclear receptor transcription pathway,GPVI-mediated activation cascade and platelet activation. It was found that aqueous extract of G. jasminoides could improve serum biochemical abnormalities in ANIT-induced cholestasis rats. Aqueous extract of G. jasminoides could decrease the protein and mRNA expression levels of ESR1 in liver tissues,and increase the protein and mRNA expression levels of PPARG,NOS2,F2 R,NOS3,and NR3 C1. To sum up,the possible mechanisms of G. jasminoides against cholestasis may be related with the above three processes and four pathways.

A Study on Major Health Components of National Health Examination Survey in Korea / 예방의학회지

The purpose of this study was to identify the major health components and measurements to be conducted in National Health Examination Survey(KNHES). The prevalence and severity of disease, acceptability of population and the possibility, of standardization of measurement were considered as guideline for selecting the components. On the base of magnitude and severity of disease, chronic liver disease, hepatic cancer, gastric ulcer, stomach cancer, essential hypertension, cerebrovascular disease, ischemic heart disease, pulmonary tuberculosis, lung cancer, DM, breast cancer, cervical cancer, arthritis and intervertebral disc disorder were selected as the preliminary target diseases. Questionnaire survey for 648 persons in 'K' city and medical specialists in five clinical societies were conducted for evaluating the acceptability of general population for the measurements and the possibility of standardization for the procedures. In conclusion, the major target diseases were chronic liver disease, hypertension and DM and the total cholesterol, high density lipoprotein, triglyceride, total protein, albumin, hemoglobulin, hematocrit, platlet count, anti-HBs, HBsAg, height and weight were selected for basic physical components.