RESUMEN
Objectives:This study was to evaluate the incidence of meconium aspiration syndrome in babies born to mothers with meconium stained amniotic uid and were to determine the risk factors leading to MSAF, the signicance of blood levels of lactate in determining severity of MAS, determine immediate perinatal outcomes of babies with MSAF and MAS and to evaluated the mortality rate of babies that develop MAS. Methodology:Atotal of 75 babies born of mothers with MSAF were enrolled in this study. Detail assessment was taken to all babies. Gestational age was calculated as per Modied Ballard score. Blood sample was taken for blood lactate levels estimation and x ray were done. Other routine investigations were performed throughout NICU stay. Results: Data was analyzed by using IBM SPSS Statistics 24 model. Pearson chi-square test and Fisher exact tests were used to assess the association between attributes. Binary logistic regression analysis was used to assess the risk factors for MAS. P value was taken ≤ 0.05 for signicant differences. Conclusions: Incidence of MAS was 10.7% of MSAF babies. MSAF and MAS were more common in Babies of para 1 and para 2 mothers. Anaemia followed by pregnancy induced hypertension was common risk factors for MSAF and MAS. MAS was more common in male babies. Term babies and who were birth weight > 3000 grams were affected with MSAF and MAS. Majority of babies with MSAF had no asphyxia. Tachypnea and expiratory grunting were commonly seen in babies with MAS. Babies with MAS, the commonest radiological ndings were observed on the right side alone (50%), followed by bilateral changes (37.5%). Majorities of babies with MAS had blood lactate levels 7.5- 15mmol/l. Blood lactate levels in MSAF babies can predict the severity of MAS. Mortality rate of babies with MAS was 12.5%.
RESUMEN
The author has studied on the differences in blood pictures, especially the differences of blood pictures in capillary blood and venous blood, in 25 premature babies and 50 term babies from birth to 7 days of age sequentially during the period of 6 monts from April 1980 to Sept. 1980. The results are summarized as follws; 1. As comparing blood pictures with term babies, premature babies showed somewhat lower values in erythrocyte, hemoglobin, hematocrit. MCV, MCH, leucocyte and platelet but somewhat higher values in reticulocyte and MCHC. 2. As comparing blood pictures with the venous blood, the capillary blood showed significantly higher values in erythrocyte, hemoglobin and hematocrit during the neonatal period in both premature babies and term babies, but showed somewhat lower values in MCV, MCH, MCHC, and platelet. 3. According to the time of clamping the umbilical cord after birth, there were significant differences of blood pictures between early and late clamping of the umbilical cord. 4. The highest mean erythrocyte counts in both term babies and premaature babies were 5,896,000/cub.mm and 5,542,000/cub.mm at 3-6 hours after birth. Those values were gradually decreased to 5,104,000/cub.mm and 4,753,000/cub.mm on the 6th-7the day of life. 5. The highest average hemoglobin levels in both term babies and premature babies were 21.1gm/dl and 19.5gm/dl at 3-6 hours after birth. Those values were gradually decreased to 18.1gm/dl and 17.1gm/dl on the 6th-7th day of life. 6. The mean values of hematocrit in both term babies and premature babies were higest, 64.5% and 59.9% at 3-6 hours after birth. Those values were gradually decreased to 54.8% and 50.2% on the 6th-7the of life. 7. The average total serum protein levels in both term babies and premature babies were 5.76gm/dl and 5.22gm/dl at birth. Those values were increased to 6.45gm/dl and 5.74gm/dl at 3- hours after birth. 8. The average MCV in both term babies and premature babies showed highest values, 114.2fl and 110.1fl at birth. Those values were gradually decreased to 107.0fl and 103.4fl on the 6th-7th day of life. 9. The average MCH in both term babies and premature babies showed highest values, 36.8pg and 35.3pg at birth. Those values were gradually decreased to 107.0fl and 103.4fl on the 6th-7th day of life. 10. The average MCHC in both term babies and premature babies showed constant levels, 31.3-32.0% and 32.2-33.1% from birth to 7the day of life. 11. The average platelet counts in both term babies and premature babies were 243,000/cub.mm and 229,000/cub.mm during the first 4 days of life. Those values were gradually increased to 283,000/cub.mm and 253,000/cub.mm on the 6th-7the day of life. 12. The highest reticulocyte counts in both term babies and premature babies were 3.1% and 3.6% at the age of 3-6 hours. Those values were rapidly dropped down from 4th day to 7th day of life, decreasing from 1.7% and 1.9% to 1.0% and 1.3%. 13. The highest llecucyte counts in both term babies and premature babies were 25,794/cub.mm and 23,363/cub.mm at the age of 3-6 hours. Both values were gradually decreased to 13,213/cub.mm and 11,870/cub.mm on the 6th-7th day of life.