Evaluation of therapeutic contact lenses used in pterygium surgery combined with limbal conjunctival autograft transplantation / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM:To evaluate the function of therapeutic contact lenses used in pterygium surgery combined with limbal conjunctival autograft transplantation(LCAT).<p>METHODS: Prospective randomized controlled study. Ninety-two patients(ninety-two eyes)with primary pterygium who underwent pterygium surgery combined with LCAT in Ophthalmology of the First Affiliated Hospital of Xi'an Jiaotong University from November 2017 to October 2018. The patients were randomly divided into a therapeutic contact lenses group and a tight bandage group. The corneal epithelial wounds were observed on the 1st, 4th, and 7th day after operation by slit lamp microscope. Then, the postoperative pain was evaluated by the visual analog scale. Last, the questionnaire was used to evaluate the eye comfort level.<p>RESULTS:There was no significant difference in corneal epithelial healing between the two groups on the first and seventh day after surgery. On the fourth day after surgery, the corneal epithelial healing was better in the therapeutic contact lenses group than in the tight bandage group(<i>P</i><0.05). In addition, the postoperative pain score in the therapeutic contact lenses group was lower than that in the tight bandage group(<i>P</i><0.05), and the eye comfort level was also higher than that in the tight bandage group(<i>P</i><0.05).<p>CONCLUSION: The therapeutic contact lenses can not only effectively promote corneal epithelial healing, but also effectively reduce pain, improve eye comfort level and improve postoperative quality of life.

Development and clinical applications of therapeutic contact lenses / 国际眼科杂志(Guoji Yanke Zazhi)

Therapeutic contact lenses, a great invention on optometry, have been widely used on clinical therapy of ocular surface diseases due to its specialty on material and structure. As a result, relevant researches and development should be focused on the optimization of its material making it more adaptable for clinical therapy. In this review, we discuss the progress in developing material of therapeutic contact lenses and mainly illustrate its mechanism and clinical application together with its complications and potential improvements.

Effect of Base Curve Radius of Therapeutic Lenses on Epithelial Healing after Laser-Assisted Subepithelial Keratectomy

PURPOSE: To determine the effect of the base curve radius (BCR) of therapeutic soft contact lens (T-lens) on epithelial healing after laser-assisted subepithelial keratectomy (LASEK). METHODS: Ninety-two eyes in 47 patients with myopia were prospectively evaluated after LASEK. All the patients wore T-lenses with the BCR (R1) randomly chosen after LASEK. The T-lenses were removed after complete healing of the epithelial wounds. We calculated an estimated BCR (R2) from postoperative topography using a diopter conversion table. The patients were divided into two groups according to the differences between the BCR (R1) and the estimated BCR (R2). The flat fitting group was R1 > R2 (Group A), and the steep fitting group was R1R2) had 53 eyes, and Group B (R1

Effect of Base Curve Radius of Therapeutic Lenses on Epithelial Healing after Laser-Assisted Subepithelial Keratectomy

PURPOSE: To determine the effect of the base curve radius (BCR) of therapeutic soft contact lens (T-lens) on epithelial healing after laser-assisted subepithelial keratectomy (LASEK). METHODS: Ninety-two eyes in 47 patients with myopia were prospectively evaluated after LASEK. All the patients wore T-lenses with the BCR (R1) randomly chosen after LASEK. The T-lenses were removed after complete healing of the epithelial wounds. We calculated an estimated BCR (R2) from postoperative topography using a diopter conversion table. The patients were divided into two groups according to the differences between the BCR (R1) and the estimated BCR (R2). The flat fitting group was R1 > R2 (Group A), and the steep fitting group was R1R2) had 53 eyes, and Group B (R1

Application of hydrogel soft contact lens to the treatment of persistence corneal epitheliopathy after intraocular surgery / 眼科

Objective To investigate the efficacy and safety of hydrogel soft contact lens(HSCL) for persistence corneal epitheliopathy after intraocular surgery.Design Retrospective case series.Participants 36 patients(36 eyes) with bullous keratopathy(n=5) or other keratopathy(n=31) including corneal erosion,epithelium missing,and dendritic keratopathy after intraocular surgery,which failed to medicine treatment 2 weeks ago.Method All patients were fitted with HSCL after suitable processing of the corneal foci.The lenses were removed immediately as long as the keratopathy recovered.A new lens was replaced after 3 weeks if still needed.Main Outcome Measures Changes of keratopathy,pain relief and complications.Result 35 patients(97.22%) fitted with HSCL were very comfort within 3 days.At the follow-up of 6 months,30 patients(83.33%) achieved complete remission of keratopathy,6 patients (16.67%) remarkable remission.30 patients(86.11%) had vision increase.All of the non-bullous keratopathy recovered within 3 weeks,while the lenses were fitted much longer in bullous keratopathy.No other lens-related complications appeared.Conclusion The application of hydrogel soft contact lens to persistence corneal epitheliopathy after intraocular surgery is safe,effective,and practical.

Microbial Contamination of Bandage Contact Lens Following Photorefractive Keratectomy (PRK)

PURPOSE: We studied to evaluate the risk of infectious keratitis in therapeutic contact lens wearer following PRK. METHODS: Forty eyes of 40 normal subjects were applied the therapeutic contact lens after PRK during corneal epithelium regeneration period and all patients used ofloxacin eye drops. After 3 to 5 days the therapeutic contact lenses were removed aseptically and we inoculated them into culture media. RESULTS: The number of culture positive contact lens was 15 (37.5%) and the number of identified organism was 17, because mixed culture (bacteria and fungus) was detected in two lens culture sets. In the 17 positive culture sets, CNS (Coagulase Negative Staphylococcus) was positive in 7 cases (41.2%), P. acnes in 3 cases (17.6%) and even pseudomonas species were positive in 2 cases (11.8%), but there was no infectious keratitis. Fungus was also detected in 4 culture sets. CONCLUSIONS: These results strongly suggest that the risk of infectious keratitis in therapeutic lens wearer after PRK is still high as in extended lens wearers. So, close follow-up for contact lens-related keratitis after PRK is essential despite of the use of antibiotic solution.

The Longterm Evaluation of Recurrent Corneal Erosion

PURPOSE: It is known that the recurrent corneal erosion is a common disease, but its treatment is quite difficult. New concept of the pathogenesis of recurrent corneal erosion has emerged. And new therapeutic trial has been applied and its effect has been great. We review the trend of therapy to propose a new treatment modality of the disease. METHODS: Thirty-one patients who were diagnosed and treated for recurrent corneal erosion in ophthalmology department of our hospital from May.1994 to May. 2001. were selected. The distribution of age, sex, the causative factor of the disease, treatment modality, duration of therapy and the complication of disease in these patients were analyzed. RESULTS: The peak age of recurrent corneal erosion was 40s to 50s. The most common causes of recurrent corneal erosion were trauma, chronic use of eyedrops is also one of the causes of recurrent corneal erosion. The treatment includes simple eye patch (41.93%), therapeutic contact lens (22.58%) and excimer laser (35.48%). The mean duration of treatment was 10.2 days and recurrence rate was 15.94%. CONCLUSION: In conclusion, recurrent corneal erosion does have organic causative factors and the disease can be well-treated with conservative therapy such as simple patch and wearing of contact lens. The surgical techniques such as excimer laser therapy have also brought successful outcome in the patients with corneal erosions of more than 6 weeks'duration.

The Effect of Topical Prostaglandin Synthesis Inhibitor and Therapeutic Contact Lens on the Pain and Corneal Reepithelialization after Excimer Laser PRK

In order to evaluate the effect of topical prostaglanduin synthesis inhibitor(Diclod) and therapeutic contact lens(T-lens) on pain control and epithelial wound healing following excimer laser photorefractive keratectomy(PRK) we examined the score of subjective pain & the degree of corneal epithelial defect on 40 consecutive patients with or without above treatment. The patients were subdivided into 4 groups : 10 patients treated with only pressure patch(Group 1), 10 patients with pressure patch & Diclod(Group 2), 10 patients with only T-lens(Group 3), and 10 patients with T-lens & Diclod(Group 4). Diclod(Group 2&4) was effective on pain control during three days after excimer laser PRK, while T-lens treatment was not effective. Subjective pain score between the patient with Diclod(Group 2&4) and those without Diclod(Group 1&3) was significantly different(p< 0.05). In the point of epithelial wound healing after excimer laser PRK, 95% of patients treated with T-lens(Group 3&4) revealed no epithelial defect three days after excimer laser PRK, while only 65% of the patients treated with pressure patch revealed that. The difference was statistially significant(p< 0.05). Diclod, however, did not influence the epithelial wound healing in both pressure group and T-lens group. In this study we could find that the combination of Diclod & T-lens was a recommendable method to decrease the pain & to increase the epithelial wound healing after excimer laser PRK.

Corneal Epithelial Wound Healing After Excimer Laser Photorefractive Keratectomy

We studied the effects of three different treating methods on corneal repithelization after PRK such as pressure patch, therapeutic contact lens and collagen shield. The degree of pain among three different treating groups showed same results without difference. The postoperative corneal wound healing rate in collagen shield group was slower than the other groups at first day. The corneal wound healing duration in therapeutic contact lens was faster than the other groups. Therefore we could obtained the results that therapeutic contact lens treated group is clinically excellent method for accelerating corneal wound healing after excimer laser photorefractive keratectomy.