A Clinical Study on Thrombocytopaenia in Viral Fevers and Malaria

Background:Thrombocytopaenia, decrease platelate count is seen in many viral fevers including heptitis 'C', HIV infections and malaria which is very comman in developing countries.[1] In Thrombocytopaenia due to viral Haemorrhagic fever, others features like increased haematocrit, leucopenia will present along with Thrombocytopaenia. Automated quatitative D3 analysis is used to detect Thrombocytopaeniain our study the commonest causes of Thrombocytopaenia is vivax malaria. Aims and Objectives: This study is to evaluate the Thrombocytopaenia as diagnostic and prognostic tool in viral fevers and malaria. Methods: In our study we have examined 200 patient’s acute febrile illness out of these 200 patients, 10 were diagnosed as dengue fever, 100 were diagnosed as Malaria. Thick and thin blood fever slides were prepared and examined by pathologist. Results: Out of 200 patients 110 were diagnosed as Malaria, 10 patients were diagnosed as Dengue fever Thrombocytopaenia is observed in 60 patients. Conclusion: Thrombocytopaenia is common in viral fevers and Malaria. After exclusion of dengue fever, malaria should be considered in all the patients with low platelet counts.

Skin eruption and thrombocytopaenia in a woman with glaucoma: a case report / Erupción cutánea y trombocitopenia en una mujer con glaucoma: reporte de un caso

Antibiotic and non-antibiotic sulphonamides are often prescribed. Although chemical differences make cross-reactivity rare, reactions may be severe in patients allergic to sulphur. Adverse reactions are common with sulphonamides but low platelets and skin changes are rarely associated with eye-drops for glaucoma. A woman treated with dorzolamide and timolol presented with disseminated eruption. On admission, her physical examination was unremarkable except for the skin changes and severe thrombocytopaenia was detected. Skin biopsy showed hyperkeratosis, acanthosis, perivascular and periadnexal infiltrates with no vasculitis. After discontinuation of eye-drops, the eruption improved but low platelets persisted. Skin changes reappeared with use of dapsone which suggested sulphonamide cross-reactivity.

A menudo se prescriben sulfonamidas antibióticas y no-antibióticas. Aunque las diferencias químicas hacen que la reactividad cruzada sea algo raro, las reacciones pueden ser severas en los pacientes alérgicos al azufre. Las reacciones adversas son comunes con las sulfonamidas pero las plaquetas bajas y los cambios en la piel raramente se asocian con las gotas oculares para el glaucoma. A una mujer a quien se le hizo un tratamiento con dorzolamida y timolol, se le presentó una erupción diseminada. En el momento del ingreso, su examen físico fue común y corriente excepto por los cambios en la piel. Además se le detectó una trombocitopenia severa. La biopsia de la piel reveló hiperqueratosis, acanthosis, infiltrados perivasculares y periadnexales sin vasculitis. Tras descontinuar las gotas oculares, la erupción mejoró pero las plaquetas bajas persistieron. Los cambios de la piel reaparecieron con el uso de dapsona, lo que hizo pensar en una reactividad cruzada de la sulfonamida.