1.
Journal of Pharmaceutical Practice
;
(6): 324-328,400, 2014.
Artículo
en Chino
| WPRIM
| ID: wpr-790351
RESUMEN
Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that play a central role in host cell recognition and responses to microbial pathogens .TLRs-mediated recognition of components derived from a wide range of pathogens and their role in the subsequent initiation of innate immune responses is widely accepted ,besides, the recent discovery of non-TLR PRRs, such as C-type lectin receptors, NOD-like receptors, and RIG-I-like receptors, suggests that many aspects of innate immunity are more sophisticated and complicated .In this review, we focused on the role cooperated by TLRs in mounting protective im-mune responses against infection and their crosstalk with other PRRs with respect to pathogen recognition .