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Objective To elucidate the distribution of human neutrophil (HNA ) antibodies among volunteer blood donors in Henan and estimate the risk rate of immune‐mediated transfusion related adverse reaction caused by HNA antibodies .Methods 156 females and 80 males were collected randomly from volunteer blood donors in Henan .All the samples′HNA antibodies were detec‐ted using LABScreen Multi kit .Results The data showed that among the 236 volunteer blood donors ,the positive rate of HNA an‐tibodies was 5 .77% (9/156)in females ,while the rates were 5 .00% (4/80)for males .Among the positive donors ,there were 7 anti‐HNA 1A ,4 anti‐HNA 4A ,1 anti‐HNA 1A/HNA 4A and anti‐HNA 1A/HNA 1C .Conclusion The frequency of HNA antibodies in females is same as the males .Our study is to elucidate the distribution of human neutrophil antibodies among volunteer blood do‐nors in Henan and estimate the risk rate of immune‐mediated transfusion related adverse reaction caused by HNA antibodies ,there‐fore it could provide theoretical basis for clinical transfusion safety .
RESUMEN
BACKGROUND: Transfusion-related adverse reaction is detected based on patients' adverse signs or symptoms during or after transfusion. We analyzed the actual incidence of transfusion-related adverse reactions by investigating diagnosed cases among reported signs or symptoms, and reexamined our transfusion-related adverse reaction reporting system. METHODS: From January to June, 2015, there were 4,234 cases of transfusion and 18,191 units of blood product were used. During transfusion, patients' signs or symptoms were checked and reported by the medical team at least three times, 5 minutes after transfusion started, during transfusion, and after transfusion, using the electronic reporting system in the blood bank. A laboratory medicine doctor investigated reported signs or symptoms by reviewing patients' electronic medical records, diagnosed transfusion-related adverse reaction by textbook definition, and surveyed actual incidence. In addition, incidence of transfusion-related signs or symptoms and transfusionrelated adverse reaction by each blood product was determined. RESULTS: Out of 1,091 transfusion-related signs or symptoms, only 226 cases (20.71%) were diagnosed with transfusion-related adverse reaction. Among these, most common cases were febrile nonhemolytic reaction with incidence of 0.91%, followed by allergic reaction with 0.32%. The incidence of transfusion-related adverse reaction by each blood product was highest for leukocyte-reduced red blood cells 3.41% and apheresis platelets 2.59%. Febrile nonhemolytic reaction was mainly related to red blood cells and allergic reaction was mainly related to platelets. CONCLUSION: The actual incidence of transfusion-related adverse reaction was only 20% of transfusion-related signs or symptoms. Therefore, reforming the reporting system and transfusion-related clinical inspection and education are required.