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Pulse arrival time is the time elapsed between the R-wave of electrocardiogram and systolic peak in peripheral pulse obtained by any of the plethysmographic methods. Similarly, differential pulse arrival time, also known as pulse transit time, is the time elapsed between systolic peaks of proximal and distal peripheral pulse recordings in an extremity. Distance between the proximal and distal site in the extremity (in meters) divided by differential pulse arrival time (in seconds) gives arterial pulse wave velocity in the limb segment. Differential pulse arrival time has been used to discriminate between an aortic or arterial block from generalized atherosclerosis in aortic and arterial occlusive diseases for nearly four decades. All along there have been efforts to monitor beat-to-beat blood pressure with the help of these time intervals and other pulse parameters. Encouraging correlation has been observed with that obtained by Finapres. Recently pulse arrival time has been explored for the prompt detection of sudden hypertensive episodes during laryngeal microsurgery, for detection of mental stress, monitoring of baroreflex sensitivity, and real-time monitoring of blood pressure. This paper briefly describes the measurement technique of pulse arrival time and an overview of its clinical applications.
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Objective:To investigate the effect and feasibility of swallowing intervention on esophageal examination by magnetically controlled gastric capsule endoscope (MCE), and to provide theoretical evidence for clinical application.Methods:From January 2021 to May 2022, 196 subjects who underwent MCE examination at West China Hospital, Sichuan University were prospectively enrolled. According to the swallowing action during MCE procedure, the subjects were divided into routine examination control group and swallowing-controlled intervention group with 98 cases in each group. The data of gender, age, history of smoking and drinking, body mass index, clinical symptoms (abdominal pain or abdominal distension, hematochezia, melena or positive fecal occult-bloodtest), esophageal transit time of MCE and detection rate of esophageal lesions were compared between the 2 groups. Wilcoxon rank sum test and chi-square test were used for statistical analysis.Results:There were no significant differences in age, gender, smoking history, drinking history, body mass index, history of diabetes, history of hypertension, and indication of MCE examination between the routine examination control group and swallowing-controlled intervention group (all P>0.05). All the subjects successfully completed the examination, and the capsules were excreted from the body. The median esophageal transit time of swallowing-controlled intervention group was longer than that of the routine examination control group (44.50 s (26.75 s, 101.25 s) vs. 11.00 s (5.00 s, 29.00 s)), and the difference was statistically significant ( Z=-8.13, P<0.001). The esophageal transit time of the patients aged 40 to 59 years old was longer than that of the patients aged <40 years old, but shorter than that of the patients aged ≥60 years old (54.00 s (36.25 s, 64.75 s) vs. 28.00 s (23.00 s, 35.00 s) and 69.50 s (64.75 s, 73.00 s)), and the differences were statistically significant ( Z=-6.72 and -6.91, both P<0.001). The detection rate of esophageal lesions of swallowing-controlled intervention group was higher than that of routine examination control group (22.4%, 22/98 vs. 11.2%, 11/98), and the difference was statistically significant ( χ2=4.41, P=0.036). Conclusion:Command-controlled swallowing can effectively prolong the time of esophagus examination by MCE, and improve the detection rate of esophageal lesions by MCE.
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Objective:To investigate the potential guiding role of fractional flow reserve(FFR) in surgical revascularization by comparing the relationship between coronary fractional flow reserve(FFR) and blood flow pattern status of bypass graft.Methods:A total of 86 patients with coronary artery disease between March 2016 to October 2019 were included in the study, with 59 males and 27 females; the age ranged from 42 to 77 years old, with an average of(58±12) years old. According to the measured FFR value of the left anterior descending artery, they were divided into severe ischemic group(FFR<0.75), boundary group(0.75≤FFR<0.80) and mild ischemic group(FFR≥0.80). Transit time flow meter(TTFM) was used to evaluate the blood flow status of the bridge vessel from the left internal thoracic artery to the left anterior descending coronary artery.Results:Mean graft flow(MGF) was measured at(21.24±5.71)ml/min, (18.25±7.72)ml/min, (16.47±7.83)ml/min in severe ischemic group, boundary group and mild ischemic group. The results of mean pulsatility index(PI) was 2.58±0.96, 3.14±1.19 and 3.53±1.34, the ratio of diastolic flow during the entire graft flow was 0.63±0.10, 0.55±0.11 and 0.53±0.11, patients appeared systolic reverse flow was 2 cases(3.6%), 3 cases(18.8%) and 3 cases (20.0%), respectively. There were statistically significant differences in MGF( P=0.027)、PI( P=0.007)、the ratio of DF( P=0.001) and the quantity of patients appeared systolic reverse flow( P=0.027) between the three groups. Conclusion:Due to increasing severity of coronary artery stenosis, MGF and the ratio of diastolic flow increased, and there appears to be an decreased PI and quantity of patients appeared systolic reverse flow. The chance of bypass graft occlusion may increase for the near and middle term in mild to moderate functional coronary artery stenosis(FFR≥0.75). For patients with severe functional coronary artery stenosis(FFR<0.75), it can obtain satisfactory flow parameters and ideal clinical outcomes.
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Objective:To analyze the influence of application of bilateral internal mammary artery(BIMA) with different configurations in coronary artery bypass grafting(CABG).Methods:From January 2018 to December 2020, 82 patients underwent CABG using BIMA were included, with 75 males and 7 females, aged(56.9±9.8) years old. According to the target of coronary artery of BIMA, patients were divided into two groups, 23 patients(group B) who underwent the traditional operation(RIMA to the right coronary artery), and 59 patients(group L) whose RIMA were grafted to the left ventricular arteries. Also the patients were divided into two groups according to the RIMA used either in situ(group I, 57 cases) or free(group F, 25 cases). Compare the grafts flow between groups. The CTA angiography of coronary artery was completed to evaluate the grafts patency before discharge.Results:There was 1 early operative death(1.22%). The mean flow(MF) of RIMA was significantly higher in group B( P=0.013). The pulsatility index(PI) of LIMA was significantly lower and the MF of RIMA and BIMA was higher(all P<0.05), fewer patients with LIMA-MF less than 15 ml/min( P=0.023)in the group I. CTA angiography before discharge showed that only 1 RIMA to right coronary artery was occlusion. Conclusion:It is better to use BIMA in situ in CABG, RIMA used in right coronary artery can receive more satisfactory graft flow. BIMA has good patency in early stage, therefore is the ideal and stable coronary bypass graft.
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Capsule endoscopy is one of the main diagnostic methods of small bowel diseases. In small bowel capsule endoscopy, the main factors that influence the diagnostic rate of diseases include gastrointestinal examination completion rate and intestinal preparation, etc. The upper gastrointestinal transit time is one of the main influence factors of examination completion rate. This article reviewed risk factors and clinical management of prolonged upper gastrointestinal transit time in capsule endoscopy.
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【Objective】 To investigate the changes in left wrist pulse wave transit time （PTT） in patients with hypertension， as well as the effects of serological indicators and unhealthy lifestyle. 【Methods】 We recruited 321 hypertensive patients admitted to Chinese PLA General Hospital Hainan Branch from June 2020 to April 2021 and divided them into two groups according to the simple randomization method. Totally 135 patients in the control group drank 20 mL of water after getting up in the morning and 186 patients in the observation group took the nifedipine controlled release tablets on the basis of the control group. A smart watch was used to collect the PTT at 0.5 h， 4.5 h， and 8.5 h after taking the medicine （drinking water） for the two groups. Repeated measurement analysis of variance was used to observe the influences of the time， interaction effect， and medicine on PTT. The data of gender， age， height， weight， left arm circumference， left arm length， resting heart rate， smoking， and alcohol drinking were collected. Fasting blood of 4 mL was collected to detect indicators such as fasting blood glucose （FBG）， total cholesterol （TC）， triglyceride （TG）， and uric acid （UA） to analyze possible factors affecting PTT. 【Results】 The time effect was statistically significant （F=12.065， P<0.001）， while the interaction effect was not （F=0.089， P=0.915）. There was no statistically significant difference between the two groups （F=2.074， P=0.155）. FBG， TC， TG， resting heart rate， and limited alcohol drinking differed significantly （P<0.05）. 【Conclusion】 PTT gradually shortens with time， and it has no significant relationship with antihypertensive drugs， but may be related to FBG， TC， TG， resting heart rate， alcohol drinking and other indicators.
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@#Introduction: The red dragon fruit (Hylocereus polyrhizus) is a popular fruit, not only where it originated from, in Central America, but across the world including in Asia. It contains healthy minerals, vitamins and antioxidants, and has been shown to have gut motility action in animals. Methods: To determine the effect of red dragon fruit on whole gut transit time, a cross-sectional study of whole gut transit time using two different stool markers was conducted among 128 young Malaysian adults. Results: Red dragon fruit, in a half fruit serving of 225±25 grams, reduced mean whole gut transit time from 26.0±12.9 hours to 21.9±12.8 hours (p<0.001) when colour change in stools was used as an indicator. The tests also showed that 14.8-17.3% of individuals had whole gut transit time ≥40 hours with carbon as a stool marker compared to only 7.8-8.6% when red dragon fruit was consumed and used as a marker. Conclusion: This study demonstrated a laxative effect of red dragon fruit among young adults.
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@#Objective To evaluate the changes of the flow parameters before and after the anastomotic port exploration and dredging during coronary artery bypass grafting by using the transit time flow measurement (TTFM). Methods A total of 167 patients who underwent continuous coronary artery bypass grafting and anastomotic port exploration and dredging surgery in Beijing Anzhen Hospital from 2018 to 2019 were enrolled in this study. There were 136 male and 31 female patients aged 41-82 (58.35±17.26) years. If the probe entered and exited the anastomotic port smoothly, it was recorded as a non-resistance group; if the resistance existed but the probe could pass and exit, it was recorded as a resistance group; if the probe could not pass the anastomotic port for obvious resistance, it was recorded as the stenosis group. In the stenosis group, the grafts were re-anastomosed and the flow parameters were re-measured by TTFM. Results A total of 202 anastomotic ports were carried out by exploration and dredging. Among them, 87 anastomosis (43.1%) were in the non-resistance group, and there was no significant change in the blood flow volume (BFV) and pulsatility index (PI) before and after exploration and dredging (6.16±3.41 mL/min vs. 6.18±3.44 mL/min, P=0.90; 7.06±2.84 vs. 6.96±2.49, P=0.50). Sixty-four anastomosis (31.7%) were in the resistance group, the BFV was higher after exploration and dredging than that before exploration and dredging (17.11±7.52 mL/min vs. 4.96±3.32 mL/min, P<0.01), while the PI was significantly smaller (3.78±2.20 vs. 8.58±2.97, P<0.01). Fifty-one anastomosis (25.2%) were in the stenosis group, and there was no significant change in the BFV and PI before and after exploration and dredging (3.44± 1.95 mL/min vs. 3.48±2.11 mL/min, P=0.84; 10.74±4.12 vs. 10.54±4.11, P=0.36). After re-anastomosis, the BFV was higher (16.48±7.67 mL/min, P<0.01) and the PI deceased (3.43±1.39, P<0.01) than that before exploration and dredging. Conclusion The application of anastomotic exploration and dredging can reduce the occurrence of re-anastomosis, and promptly find and solve the stenosis of the distal coronary artery, improve the poor perfusion of distal coronary, and thus improves the prognosis of patients.
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Objective: To explore the influence of gender, age and body mass index (BMI) on small intestinal transit time (SITT). Methods: A total of 181 patients admitted to in the Third Medical Center of Chinese PLA General Hospital during September 2012 to December 2018 for capsule endoscopy were selected and their age, gender, BMI and SITT were analyzed. The Mann-Whitney U test was utilized to compare the differences of SITT in patients of different genders. Spearman ρ test and multiple linear regression analysis were adopted to explore the relationship between different physiological variables age, gender, BMI and patient SITT. Results: The median SITT were 267.5 minutes for females and 252.0 minutes for males. Although the median SITT was 15.5 minutes longer in women than men, no statistical significance was found (P=0.360). There was positive correlation between age and SITT (ρ=0.22, P=0.002), and negative correlation between BMI and SITT (ρ=-0.17, P=0.02). Conclusion: The differences in drug bioavailability of modified-release preparations can not be attributed to SITT among patients of different genders, but may be related to SITT among patients of different ages and BMI.
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Objective To evaluate the application value of quantitative parameters of contrast-enhanced ultrasound (CEUS) in evaluating the donor liver from donation after brain death (DBD). Methods Clinical data of 25 DBD donor livers and 10 healthy adult livers were retrospectively analyzed. CEUS examinations of DBD donor livers and healthy livers were collected. Quantitative parameters included the area under curve (AUC), maximum intensity (Imax), time to peak (TTP) and mean transit time (mTT), etc. Results Among 25 cases of DBD donor livers, 23 cases showed normal enhancement pattern, and the other 2 cases presented with abnormal enhancement pattern. Compared with the control group, the AUC, Imax and mTT values of DBD donor livers were significantly decreased (all P < 0.05). Conclusions CEUS quantitative parameters can be effective means to evaluate the micro-perfusion of DBD donor livers.
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Background: Students usually prefer to play games on theirmobile phones to avoid stress which is a major cause of CVDnowadays. CVR to stress can be assessed throughcardiovascular parameters such as blood pressure, heart rateand pulse transit time. The present study was conducted tocompare the Cardiovascular Reactivity (Heart rate, bloodpressure, pulse transit time) before, during and after playingmobile games and to compare cardiovascular parameters onthe 1st day and last day of study.Materials and Methods: This cross-sectional study wasconducted among 100 MBBS students in the age group of 19to 22 years at KD Medical College, Hospital and ResearchCentre, Mathura. Subjects over the period of 2 months wereselected for the study. The subjects were asked to have a lightbreakfast. Then in the sitting position; cardiovascularparameters and anthropometric data of the subjects weretaken 10 minutes before the game. All the rules of(CRASHLAND) mobile game were explained to the subjectsbefore letting him/her to start the game. After taking theseparameters the subject were asked to play the mobile game for30 minutes. Then the game was withdrawal and within 10minutes of interval; all these parameters were taken again. Ifany discomfort was reported by the subject then he/she wasexcluded from this study. Data was analyzed using SPSSversion 20. Variation of Cardiovascular Reactivity before,during and after playing mobile games were accessed byRepeated Measure ANOVA. Comparison of cardiovascularparameters on the 1st day and last day of study of a subjectwas accessed by Paired “t” Test.Results: A positive correlation was found between the BMIand various CVR parameters such as heart rate, SBP, DBP,MAP, pulse transit time, pulse wave velocity during and afterplaying the game. Repeated measure ANOVA analysed thatthere was no significant increase in pulse wave velocity of thesubject before, during and after playing mobile game. One wayANOVA analysed that there was significant increase in SBPand DBP of the subject, suggesting increased stressassociated with playing mobile games.Conclusion: Our study concluded that a positive correlationwas found between the BMI and various CVR parameters suchas heart rate, SBP, DBP, MAP, pulse transit time, pulse wavevelocity during and after playing the game.
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Continuous and non-invasive measurement of blood pressure (BP) is of great importance particularly for patients in critical state. To achieve continuous and cuffless BP monitoring, pulse transit time (PTT) has been reported as a potential parameter. Nevertheless, this approach remains very sensitive, cumbersome and disagreeable in ambulatory measurement. This paper proposes a new approach to estimate blood pressure through PCG signal by exploring the correlation between PTT and diastolic duration (S21). In this purpose, an artificial neural network was developed using as input data: (systolic duration, diastolic duration, heart rate, sex, height and weight). According to the NN decision, the mean blood pressure was measured and consequently the systolic and the diastolic pressures were estimated. The proposed method is evaluated on 37 subjects. The obtained results are satisfactory, where, the error in the estimation of the systolic and the diastolic pressures compared to the commercial blood pressure device was in the order of 6 .48 ± 4.48 mmHg and 3 .91 ± 2.58 mmHg, respectively, which are very close to the AAMI standard, 5 ± 8 mmHg. This shows the feasibility of estimating of blood pressure using PCG.
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Humanos , Presión Sanguínea , Frecuencia Cardíaca , Métodos , Análisis de la Onda del PulsoRESUMEN
Cuffless technique holds great promise to measure blood pressure (BP) in an unobtrusive way, improving diagnostics and monitoring of hypertension and its related cardiovascular diseases, and maximizing the independence and participation of individual. Pulse transit time (PTT) has been the most commonly employed techniques for cuffl ess BP estimation. Many studies have been conducted to explore its feasibility and validate its performance in the clinical settings. However, there is still issues and challenges ahead before its wide application. This review will investigate the understanding and development of the PTT technique in depth, with a focus on the physiological regulation of arterial BP, the relationship between PTT and BP, and the summaries of the PTT-based models for BP estimation.
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Presión Sanguínea , Enfermedades Cardiovasculares , Hipertensión , Análisis de la Onda del PulsoRESUMEN
Objective To establish the regression equation of blood pressure in population based on the pulse wave transit time (PWTT) and verify its accuracy. Methods A convenient sampling method was used to collect gender, age, arm circumference, arm length, PWTT, history of hypertension, and body height, etc. of 4 121 outpatients' information from the Hainan Branch of Chinese PLA General Hospital from June 2016 to May 2018 to establish a binary variable logistic regression equation for blood pressure elevation or not and screen out the influencing factors of time point blood pressure. The accuracy of the equation was then verified in 252 outpatients. Results Logistic regression analysis showed that PWTT, gender, age, history of hypertension present or not, body height might be the influencing factors of blood pressure elevation [odds ratio (OR) values were 0.995, 0.530, 0.980, 107.128, 0.979, 95% confidence interval (95% CI) were 0.991-0.999, 0.405-0.695, 0.971-0.989, 73.935-155.223, and 0.962-0.996, respectively, all P < 0.05]. The classification prediction equation: Ln [P / (1-P)] = 2.087-0.005×PWTT-0.635×gender (man = 1, woman = 2)-0.02×age + 4.674×hypertension history present or not-0.021×body height [P indicates the probability of a positive result: systolic blood pressure≥140 mmHg (1 mmHg = 0.133 kPa) and/or diastolic blood pressure≥90 mmHg]. The overall test results showed that χ2 = 1 835.305, P < 0.05, statistically significant; The goodness of fit test results:χ2 = 5.881, P > 0.05, the data was conform to the equal proportion distribution. Model-confirmed results showed that in patients with a history of hypertension, the probability of predicting accuracy was 95%-99%. In patients without a history of hypertension, the probability of predicting accuracy was 45%-89%. Conclusion The predictive value of blood pressure elevation with this model in patients with a history of hypertension is superior to that of patients without the history of hypertension.
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Objective To analyze the colonic transit time in patients with different severities of constipation.Methods From June, 2015 to September, 2017, 73 male patients with supraconal spinal cord injury were grouped as mild constipation group (n = 25) and severe constipation group (n = 48). They were measured the transit time of entire colorectum, ascending colon (including the right colic flexure), transverse colon, descending colon (including the left colic flexure) and rectosigmoid with Abrahamsson method.Results The transit time of entire colorectum, transverse colon, descending colon increased in the severe constipation group compared with that of the mild constipation group (P ＜ 0.05). For each group, the transit time of rectosigmoid was the longest among colon segments (P ＜ 0.05).Conclusion The colonic transit time of SCI male patients with various constipation is different in colon segments. Accurate interventions are needed to target colon segments.
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Objective:To analyze the relationship of hepatic transit time and portal vein pressure in the patients with portal hypertension and esophagogastric varices, and to clarify its clinical significance.Methods:A total of50hospitalized patients underwent esophagogastric venous embolization due to portal hypertension and esophagogastric varices were selected as observation group, and 50patients without history of liver disease and clinical manifestations of liver disease (hospitalized or out-patient) were selected as control group, All patients underwent liver contrast enhanced ultrasound.The free portal pressure (FPP) was measured by ultrasound guided portal vein puncture for operating pathways in the patients in observation group.The hepatic artery-hepatic vein transit time (HA-HVTT) , the hepatic portal vein-hepatic vein transit time (PV-HVTT) , the liver parenchymahepatic vein transit time (PA-HVTT) of the patients were compared between two groups.The correlations between HA-HVTT, PV-HVTT, PA-HVTT and FPP of the patients in observation group were analyzed.Results:The HA-HVTT, PV-HVTT and PA-HVTT of the patients in observation group were significantly shorter than those in control group (t=5.078, P＜0.01;t=12.163, P＜0.01;t=2.649, P＜0.01) .The HA-HVTT, PV-HVTT and PA-HVTT had negative correlations with FPP in observation group (r=-0.799, P＜0.01;r=-0.554, P＜0.01;r=-0.735, P＜0.01) .The linear relationship between HA-HVTT and FPP was Y=-0.410X+7.254;the linear relationship between PV-HVTT and FPP was Y=-0.355X+4.983;the linear relationship between PA-HVTT and FPP was Y=-0.566X+4.997.Conclusion:Liver transit time can be used as an effective index to judge the portal vein pressure, and it can provide the theroretical basis for the diagnosis and treatment of portal hypertension in the patients.
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Objective: To analyze the relationship of hepatic transit time and portal vein pressure in the patients with portal hypertension and esophagogastric varices, and to clarify its clinical significance. Methods: A total of 50 hospitalized patients underwent esophagogastric venous embolization due to portal hypertension and esophagogastric varices were selected as observation group, and 50 patients without history of liver disease and clinical manifestations of liver disease (hospitalized or out-patient) were selected as control group. All patients underwent liver contrast enhanced ultrasound. The free portal pressure (FPP) was measured by ultrasound guided portal vein puncture for operating pathways in the patients in observation group. The hepatic artery-hepatic vein transit time (HA-HVTT), the hepatic portal vein-hepatic vein transit time (PV-HVTT), the liver parenchyma- hepatic vein transit time (PA-HVTT) of the patients were compared between two groups. The correlations between HA-HVTT, PV-HVTT, PA-HVTT and FPP of the patients in observation group were analyzed. Results: The HA-HVTT, PV-HVTT and PA-HVTT of the patients in observation group were significantly shorter than those in control group 0=5.078, P<0. 01; t=\2. 163, P<0. 01; t=2. 649, PC0.01). The HA-HVTT, PV-HVTT and PA-HVTT had negative correlations with FPP in observation group ( r= 0.799, P
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Several techniques are used to make a capsulorhexis in white mature cataract cases as needle cystotome, Utrata capsulorhexis forceps, microincision capsulorhexis forceps, femtosecond Laser, etc. Zepto precision nano-pulse capsulotomy device (Mynosys Cellular Devices; Fremont, CA, USA) is Food and Drug Administration approved, a disposable capsulotomy device that uses low-energy pulses to create a precise central capsulorhexis, independent of pupil size, corneal clarity, or lens density. In this article, the authors report their experience of performing anterior circular curvilinear capsulorhexis with Zepto precision nano-pulse capsulotomy device in challenging cataract cases done at our center. The Zepto handpiece device was inserted through 2.8 mm clear corneal incision. Results of our study in 3 cataract cases (intumescent cataract, morgagnian cataract, and cataract with small pupil) revealed that the precision pulse capsulotomy technology mechanically and simultaneously cleaves all 360� of the apposed capsule of without cauterizing it, creating CCC of 5.2 mm size.
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Purpose: The purpose of the study was to evaluate the functional success rates using dacryoscintigraphy (DSG) after transcanalicular diode laser dacryocystorhinostomy (TDL-DCR). Methods: In this retrospective study, we investigated the records of 56 patients who underwent TDL-DCR for unilateral primary acquired nasolacrimal duct obstruction and anatomic patency was achieved. The lacrimal drainage systems of the other eyes of the patients were normal and were selected as control group. The functional success was evaluated with tear transit time (TT) on DSG and epiphora complaints' score (ECS) at postoperative 6 months. Results: Twenty-two (39%) of the patients were male and 34 (61%) were female, with a mean age of 46.6 (21�). The dacryoscintigraphic findings of the operated and healthy eyes showed that there was statistically insignificant prolongation in the tear TT at the operated side at postoperative 6th month (P > 0.05). The mean ECS of operated eyes was 0.89. Functional success was achieved in 43 (76.8%) patients when the ECS of 0 and 1 was accepted as successful. A statistically significant delay in drainage was observed in DSG in all of the cases with epiphora score of 2 and 3 (P < 0.05). The tear TT was prolonged with the age increase (P < 0.05), but there was no significant difference concerning the gender. Conclusion: DSG is an effective tool to evaluate the functional success of TDL-DCR.
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OBJECTIVE:To observe therapeutic efficacy and safety of prucalopride in the treatment of chronic constipation (CC). METHODS:Totally of 100 CC patients were selected from anorectal department of our hospital during Jun. 2016-Jan. 2017, and then divided into control group and observation group according to random number table,with 50 cases in each group. Control group was given Mosapride citrate tablets 5 mg +Lactulose oral solution 10 mL orally,3 times a day. Observation group was given Prucalopride succinate tablets 2 mg orally,once a day. Both groups were treated for consecutive 4 weeks. Clinical efficacies of 2 groups were observed,and the levels of serum inflammatory factors(IL-6,TNF-α,IFN-γ)and colonic transit time(total colonic transit time,left colonic transit time,right colonic transit time,rectosigmoid colonic transit time)were observed before and after treatment. The occurrence of defecation disorders and ADR were recorded. RESULTS:None of patient in 2 groups was cured. Total response rate of observation group was 94.00%,which was significantly higher than 78.00% of control group,with statistical significance (P＜0.05). Before treatment,there was no statistical significance in the levels of serum inflammatory factors or colonic transit time (P＞0.05). After treatment,the levels of IL-6 and IFN-γ in control group,the levels of IL-6,TNF-α and IFN-γ in observation group were decreased significantly,and the levels of IL-6,TNF-α and IFN-γ in observation group were significantly lower than those of control group;the colonic transit time in 2 groups was shortened significantly,and observation group was significantly shorter than control group,with statistical significance (P＜0.05). After treatment,the incidence of defecation,incomplete emptying,sense of obstruction and sense of rectal tenesmus in observation group were significantly lower than control group,with statistical significance(P＜0.05). There was no statistical significance in the incidence of sense of rectal tenesmus after treatment or ADR between 2 groups (P＞0.05). CONCLUSIONS:Compared with traditional plan of mosapride combined with lactulose,prucalopride can more effectively reduce the levels of serum inflammatory factors,shorten colonic transit time,reduce the occurrence of defecation disorders as defecation and incomplete emptying,with equivalent safety.