Effects of a mucoadhesive formulation containing Curcuma longa L. on oral wound healing

Introduction: The aim of this study was to investigate the effects of a topical mucoadhesive formulation with Curcuma longa L. extract (MFC) on oral wound healing. Methods: Seventy-two Wistar rats were randomly assigned to 3 groups: Control, Vehicle, and MFC. Traumatic ulcers were made on the dorsum of the tongue with a 3-mm diameter punch. Vehicle and MFC groups received application of the products twice a day, while animals in the control group were cared for in identical conditions but received no product application. Six rats in each group were euthanized at days 3, 5, 10, and 14. Percentage of repair was calculated based on wound area. HE-stained histological sections were obtained for semi-quantitative analysis of re-epithelization and inflammation. Results: Clinical findings revealed that at days 3 and 5, animals from the MFC group exhibited a significantly higher percentage of wound repair. At day 5, animals from this group also demonstrated a significant increase in the degree of re-epithelization and inflammation. Conclusions: MFC is capable of accelerating oral wound repair in an in vivo model by modulating the inflammatory process and stimulating epithelial proliferation. (AU)

Comparative Evaluation of the Effects of Two Different Local Drug Delivery Systems Incorporating Green Tea and Turmeric Extracts in the Treatment of Chronic Periodontitis: A 2-month Clinical Trial

Aim: This randomized, triple-blinded parallel study was aimed to evaluate the effects of two different local drug delivery (LDD)systems incorporating green tea and turmeric extracts as an adjunct to scaling and root planing (SRP) in the treatment ofchronic periodontitis (CP).Materials and Methods: Thirty-four subjects randomized to receive either Gel A or Gel B containing green tea or turmericextract were included in the study. Following SRP, probing pocket depth (PPD), relative attachment level, gingival marginposition (GMP), bleeding on probing, gingival index, and periodontal inflammatory surface area were recorded at baseline and8 weeks after treatment with Gel A or Gel B.Results: Mean PPD reduction from baseline to 8 weeks was −24.57% for Gel A while for Gel B, it was −22.99%. On comparisonof GMP values for Gel A and Gel B at baseline (3.03±1.10 and 2.80±1.06) and at the end of 8 weeks (3.27±1.41 and 3.27±1.14),a statistically significant difference was noted. However, the percentage change was positive (7.69% and 16.67%) in both groups.Conclusion: Both LDD gel systems were equally beneficial and showed a noteworthy reduction in the clinical parametersrecorded when used as an adjunct to SRP in the treatment of CP.