Resistance training with blood flow restriction and cognition in elderly women (project "forte-mente-ativa"): study protocol

Abstract Aim: In the process of aging, there is a decrease on muscle strength and cognitive function. Resistance training combined with blood flow restriction (BFRRT) has been shown capable of maintaining or improve aspects of physical health. However, the effects of BFRRT the cognitive function of the elderly are not clear. This study aimed to describe the design of a randomized controlled clinical trial, that will investigate the effects of BFRRT on cognitive function, physical performance and physiological and morphological aspects in elderly women. Methods: Forty participants will be randomized into one of the following groups: low load resistance training, blood flow restriction resistance training, moderate load resistance training or Control. All intervention groups will complete 16 weeks of resistance training, three times week (45 minutes each), with training consisting of four exercises for the upper and lower body, including three sets of ten repetitions each. No exercise will be performed by the Control group. Cognitive function will be the primary outcome of the study. Secondary outcomes will include body composition, muscle strength, functional capacity, double-task, level of physical activity, static and dynamic balance, brain activity, BDNF neurotrophic factor, anxiety, depression and sleep state). Conclusion: This project will contribute to the existing knowledge and will have a social impact regarding the use of physical exercise as a non-pharmacological tool for the mental and physical health older individuals. Trial Registration: Brazilian Registry of Clinical Trials number RBR-7BC8ZP.

The application of 320-slice CT with dual-low-dose in whole brain perfusion imaging in detection of acute cerebral ischemia / 实用放射学杂志

Objective To investigate the feasibility and value of CT perfusion imaging in combination of CTA 320-slice CT with dual-low-dose in detection of acute cerebral ischemia.Methods Forty patients with acute stroke underwent perfusion imaging and CTA using a single scan with 320-slice CT with dual-low-dose schedule.CTA,4D-CTA,4D-perfusion imaging and fusion images were generated at a post-processing workstation.All patients also underwent a 3.0T magnetic resonance imaging with DWI for a comparison.Quality of the images,degree of vascular stenosis,and location of ischemic lesions were evaluated.Results The vascu-lar stenosis or occlusion was found in 33 patients,8 of whom were confirmed by the DSA.The ratio of better images of CTA was 82.5%.CTP showed 297 lesions with abnormal perfusion.202 lesions were confirmed as infarct by DWI,while 95 ones were nor-mal on DWI but with increased DLY and TTP and slightly decreased CBF and CBV in 49,increased DLY and TTP and normal CBF and CBV in 21,and increased DLY and TTP and slightly increased CBF and CBV in 25.Conclusion CT perfusion in combination with CTA by 320-slice CT with dual-low-dose is feasible and useful to observe accurately the vascular structures and the ischemic status of the whole brain at early stage.