Research progress of venous congestion after deep inferior epigastric perforator flap breast reconstruction / 中华整形外科杂志

Breast reconstruction with deep inferior epigastric perforator flap (DIEP flap) is an optimal technique for massive tissue defect after breast cancer surgeries. Venous congestion is one of the main complications and the probable reasons include thrombus, lack of ramus communicans across the midline or between deep and superficial system, improper choice of anastomotic vein, et al. Clinical examination is the main method, and other auxiliary tests can also be used. Preoperative vascular evaluation is of great importance. The venous superdrainage is current preventive measure for congestion.

Effect of cyclophosphamide on the microanatomy of liver of albino rats.

Background: Cyclophosphamide is widely used in the treatment of various neoplastic diseases and diseases associated with altered immunity. Higher doses used for longer duration effects many organs like urinary bladder, lungs, liver, heart and male reproductive organs. Methods: To study the effect of cyclophosphamide on the micro anatomy of liver, sixty eight Albino rats were taken and divided into three groups, group A (control group) of 20 animals, were fed with routine diet, group B (low dose group) of 24 animals, were given cyclophosphamide at the dose of 0.5 mg/100 gms in addition to the routine diet and group C (high dose group) of 24 animals, were given high dose of cyclophosphamide at the dose of 0.7 mg/100 gms of weight of animal in addition to the routine diet. The animals were sacrificed at intervals of 3, 6, 9 and 12 weeks, 5 microns sections of the tissue were prepared and stained with Haematoxylin and Eosin stain. Results: Microscopic changes in liver were apparent in the drug treated animals. In group B the changes appeared after 6 weeks while in group C they started appearing after 3 weeks of drug treatment. The changes were in the form of fatty changes, hemorrhages and central vein congestion. Conclusion: Cyclophosphamide induces histological changes like fatty infiltration and central vein congestion in the liver. These changes are with low doses given for longer durations and manifest earlier when larger doses are used. Thus it is advised that patients receiving cyclophosphamide should be periodically evaluated for liver dysfunction.