Polyaspartic acid grafted dopamine polymer chelated Fe 3+ for magnetic resonance imaging visual photothermal therapy agent / 生物医学工程学杂志

This study aims to explore the potential of polyaspartic acid grafted dopamine copolymer (PAsp- g-DA) chelated Fe 3+ for magnetic resonance imaging (MRI) visual photothermal therapy. Polyaspartic acid grafted copolymer of covalently grafted dopamine and polyethylene glycol (PAsp- g-DA/PEG) was obtained by the ammonolysis reaction of poly succinimide (PSI), and then chelated with Fe 3+ in aqueous solution. The relaxivity in vitro, magnetic resonance imaging enhancement in vivo and photothermal conversion effect at 808 nm were investigated. The results showed that polymeric iron coordination had good near-infrared absorption and photothermal conversion properties, good magnetic resonance enhancement effect, and good longitudinal relaxation efficiency under different magnetic field intensities. In summary, this study provides a new magnetic resonance visual photothermal therapeutic agent and a new research idea for the research in related fields.

Consideraciones actuales en la insuficiencia de convergencia / Current considerations about convergence insufficiency

La insuficiencia de convergencia es un problema común de coordinación muscular en el cual los ojos tienden a desviarse hacia afuera exoforia con la lectura o cuando se realizan actividades de cerca. Los síntomas más característicos son los astenópicos. Es una de las causas más frecuentes de disconfort ocular. Se diagnostica cuando la exoforia es mayor de cerca y el paciente tiene uno o ambos de los siguientes signos: un punto próximo de convergencia remoto y/o reserva fusional positiva reducida. No existe un consenso para su diagnóstico y tratamiento, aunque muchos coinciden en que la terapia visual y la aplicación de los adelantos técnicos donde los programas de computación juegan un papel importante logran una pronta mejoría en estos pacientes

Convergence insufficiency is a common eye muscle coordination problem in which the eyes tend to drift outward (exophoria) when reading or doing some work at near distance. The most frequent symptoms are the asthenopics. Convergence insufficiency is one of the most common causes of ocular discomfort. The diagnosis is based on exophoria greater at near distance, a remote near point of convergence and decreased convergence amplitudes. There is not any consensus whatsoever about diagnosis and treatment, although many agree on the fact that the visual therapy and the application of technical advances - computer software packages play an important role - manage to attain rapid visual improvement in these patients