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Objective: To measure the occipital lobe volume in different genders of healthy Han Chinese adults with MRI. Methods: A total of 200 volunteers were selected from the healthy adult brain database of Han nationality in China. Whole-brain images were obtained using 3D magnetization prepared rapid acquisition gradient echo T1W sequence. The volume of left and right occipital lobes and whole brain volume were measured with manually sketching ROIs. Then the measured data were standardized, and the volume of left and right lateral occipital lobe were compared between different genders, the relation of the occipital lobe volume and age was analyzed, and the influence of gender and age to occipital lobe volume was analyzed. Results: The occipital lobe volume of normal adult was (105.37±10.41) cm3, which was (105.44±9.20) cm3 after standardization. Before standardization, the volume of occipital lobe in male adults ([111.34±9.15] cm3) was statistically different from that in females ([99.38±7.85]cm3), while after standardization, the volume of occipital lobe in male adults ([111.39±7.31]cm3) was also statistically different from that in females ([99.48±6.72]cm3,t=9.91, 12.01, both P0.05). Before and after standardization, no obvious correlation of occipital lobe volume with age in males or in females was observed (r=-0.01, 0.18, P=0.90, 0.08; r=0.05, 0.01,P=0.64, 0.92). There was no interaction between genders nor age on occipital lobe volume. Conclusion: The occipital lobe volume of healthy male adults is larger than that of females, and the volume of bilateral occipital lobe is basically the same in different genders. The occipital lobe volume is less likely to atrophy with age.
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Objective To investigate the eyelid and orbital development of congenital microphthalmia. Design Prospective case se- ties. Participants 23 eyes of 23 patients with congenital microphthalmia aged from 6 months to 78 months. Methods The parameters of palpebral fissure length (PFL), palpebral fissure height(PFH) were measured in all patients. Also, combining the computer tomography (CT) imaging with the computer-aided design system, the anteroposterior axis of eyeball and orbital volumn were calculated automatically. To e- valuate the influence factor of eyelid and orbital growth, correlations between age, anteroposterior axis of eyeball and PFL, PFH, orbital volumn were analyzed. Main Outcome Measures PFL, PFH, anteroposterior axis of eyeball and orbital volumn. Results The PFL, PFH, anteroposterior axis of eyeball and orbital volumn in micro-side were (16.44?3.24) mm, (2.47?1.48) mm, (11.99?3.33) mm, (14.19?2.37) ml respectively. These parameters above were all significantly smaller than the unaffected side (all P=0.000). Moreover, orbital volume showed a strong linear correlation with the anteroposterior axis of eyeball and age(r=0.62, 0.63;p=0.037, 0.035). Both PFL and PFH were corelated with the anteroposterior axis of eyeball (r=0.54, 0.53; P=0.030,0.034), while showing no significant difference with age. According to the an- teroposterior axis of eyeball, two groups, including group less than or equal to 12 mm (10 cases) and group more than 12 mm (13cases), whose PFL,PFH and orbital volumn were (13.50?1.97) mm, (1.08?0.66) mm; (12.73?0.95) ml, (18.20?2.49) mm; (3.30?1.16) mm, (15.05?2.57) ml, respectively. They had statistically significant difference in PFL, PFH and orbital volumn (P=0.001, 0.003,0.024). Conclusion The development of eyelid and orbit with congenital microphthalmia is obviously retarded. The smaller the eyeball is, the much worse in- fluence in eyelid and orbital growth is. The intervention therapy in early stage as far as possible is fundamental approach in simulating the eyelid and orbital development, or preventing and reducing the incidence of orbital deformity.
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OBJECTIVE:To make clear the present status and developing trend of drugs used in enterprise hospitals and municipal hospitals in Chongqing between2001～2003to offer reference information for the departments concerned.METHO_ DS:The data of drugs used in enterprise and municipal hospitals in Chongqing were retrospectively analysed.RESULTS:In enterprise hospitals and municipal hospitals,the annual increasing rates of sales volumn of drugs were8.24%and18.29%;the anti-infectives accounted for40%～41%and36%～40%of annual sales volumn and sales volumn of imported drugs amounted to4.40%and14.78%of total drugs consumed respectively.CONCLUSION:The sales volumn of drugs in enterprise hospitals is decreasing year by year,while that in municipal hospitals is increasing.