Expression of WDHD1 protein in esophageal squamous cell carcinoma and its relationship with clinical significance / 中国医师进修杂志

Objective To investigate the clinical significance of WDHD1 protein expression in esophageal squamous cell carcinoma.Methods The expression of WDHD1 protein in esophageal squamous cell carcinoma,adenocarcinoma of esophagus and normal esophagus tissues by immunohistochemical MaxVision was detected.Results The expression of WDHD1 protein in the tissues of esophageal squamous cell carcinoma was significantly higher than that in the normal esophagus tissues and adenocarcinoma of esophagus (15.68 ± 3.01 vs.3.89 ± 2.98 and 4.66 ± 2.46)(P ＜ 0.05),there was no significant between normal esophagus tissues and adenocarcinoma of esophagus (P ＞ 0.05).The expression of WDHD 1 protein in the tissues of esophageal squamous cell carcinoma,high-middle differentiation tissues was higher than poorly differentiation,TNM stage Ⅲ + Ⅳ stage was higher than Ⅰ + Ⅱ stage,depth of invasion T3 + T4 was higher than T1 + T2,with lymph node metastasis tissue was higher than without,differences was statistically significant (P ＜0.05).Conclusions The higher expression of WDHD1 protein is the marker of high invasive and low histological grade of esophageal squamous cell carcinoma,and WDHD1 in esophageal squamous cell carcinomas may play an important role in development.

Perimenstrual Symptoms of Korean Women Living in the USA: Applicability of the WDHD(Women's daily health diary)on Prospective Report / 간호학회지

PURPOSE: To compare perimenstrual (premenstrual, menstrual, postmenstrual) symptoms by concurrent reporting using the Women's Daily Health Diary (WDHD) and by retrospective reporting using the Moos Menstrual Distress Questionnaire (MMDQ). METHODS: A prospective and retrospective study was conducted among 31 Korean women, aged 27 to 48 yrs, living in the USA. RESULTS: On the prospective report using the WDHD, the most severe complaints were fatigue or tiredness (1.48 +/-.98), sensation of weight gain (.88+/-98), increased appetite (.79+/-.96) in premenstrual phase, fatigue or tiredness (1.34+/-.85), backaches (1.06+/-.79), and bloating or swelling of the abdomen (.93+/-.86) during the menstrual phase. On the retrospective report using the MMDQ, the most severe complaints during the premenstrual phase were fatigue (2.2 6+/-1.65), irritability (2.06+/-1.48), and backaches (1.97+/-1.68) and during the menstrual phase backaches (2.35+/-1.62), fatigue (2.29+/-1.75), and cramps (2.23+/- 1.80). According to both measurements of PMS symptomology during the premenstrual and menstrual phases, the most frequently reported symptom was fatigue or tiredness. Highly rated symptoms on the MMDQ and on the WDHD were found to be similar. CONCLUSION: The WDHD was found to be suitable for daily prospective PMS assessment, which will be necessary for the screening and management of women with severe PMS.