Research progress of YKL-40 protein in ocular diseases / 中国医师杂志

YKL-40 protein, also called chitinase 3 like 1 (CHI3L1), is a highly conserved secreted glycoprotein in racial evolution, belonging to the " 18-glycosyl hydrolase" family. A large number of studies have shown that YKL-40 is involved in the pathological process of many diseases. There is little research information about YKL-40 in ocular diseases yet. This article mainly summarizes the research progress of YKL-40 in ocular diseases in the domestic and foreign literatures to provide reference for further clinical research.

Research progress on YKL-40 protein in tumor / 肿瘤研究与临床

Tissue expression and blood level of YKL-40 protein are elevated ia patients with tumor.The protein may have a role in cancer cell proliferation,infiltration,metastasis and remodelling of tumor stroma.Elevated YKL-40 levels are highly associated with short survival and poor response to treatment for patients.Thus,YKL-40 may serve as a biomarker in diagnosis of disease,evaluation of severity and assessment of prognosis.It's more likely to be a new target for anti-tumor treatment.