RESUMEN
Objective:To explore the clinical effect and safety of Yikunning granules combined with tibolone and paroxetine in the treatment of female patients with menopausal syndrome. Methods:Totally 150 female patients with menopausal syndrome were randomly divided into the control group (75 cases) and the study group (75 cases). The control group was orally given tibolone (2. 5mg,po,qd) and paroxetine tablets (20mg,po,qd), and the study group was treated with Yikunning granules additionally (3g,po,tid). After 3-month treatment, the modified Kupperman score was used to evaluate the clinical symptoms, radioimmunoassay was used to detect the serum lev-els of estradiol (E2), luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL) and progesterone (P), and the adverse reactions were recorded. Results:After the treatment, most of the indices in the modified Kupperman score were improved in the two groups (P0. 05). The improvement of E2, LH and FSH in the study group was better than that in the control group (P<0. 05). There was no significant difference in the adverse reactions between the two groups (P<0. 05). Conclusion:Yikunning granules combined with tibolone and paroxetine show good effectiveness in the treatment of menopausal syndrome with improved clinical symptom and sex hormone levels, which is worthy of promotion.