Q-markers of Yuquan Capsules based on serum pharmacochemistry of Chinese medicine / 中国中药杂志

This study analyzed the quality markers(Q-markers) of Yuquan Capsules(YQC) based on serum pharmacochemistry of Chinese medicine and detected the components and metabolites of YQC absorbed into the blood by UPLC-Q-TOF-MS and UNIFI systems. As a result, 32 components of YQC were detected, including 17 prototype components and 15 metabolized components. Among them, 12 prototype components(ginsenoside Rh_2, genistein, formononetin, puerarin, daidzein, schizandrin A, schizandrin B, schizandrin C, schizandrol A, schizandrol B, gomisin D, and ononin) and 12 metabolized components(ginsenoside Rg_1, ginsenoside Rg_2, ginsenoside Rg_3, ginsenoside Ro, 3'-methoxypuerarin, daidzin, astragaloside Ⅱ, astragaloside Ⅳ, glycyrrhizic acid, liquiritigenin, isoliquiritin, and verbascoside) showed inhibitory effects and pharmacological activities against diabetes, and these 24 blood-entering components against diabetes were identified as Q-markers of YQC.

Study on Quality Standard of Yuquan Capsules / 中国药房

OBJECTIVE: To establish the quality standard of Yuquan capsules. METHODS: The composition of Yuquan capsules, such as Puerariae lobata, Panax ginseng, Glycyrrhiza uralensis, Astragalus membranaceus, Schisandrae chinensis, were identified by TLC. The content of puerain was determined by HPLC. RESULTS: The identified components of Yuquan capsules were P. lobata, P. ginseng, G. uralensis, A. membranaceus, S. chinensis. The linear range of puerain were 0.127 5～1.02 ?g(r=0.999 9) with an average recovery of 100.29%(RSD=1.68%). CONCLUSION: Established standard can be used for the quality control of Yuquan capsules.