Acute exercise induces mitochondrial swelling of hepatocytes surrounding the terminal hepatic venule in rat liver acinus / 体力科学

In this study, we investigated the effect of acute exercise on the mitochondrial structure of hepatocytes surrounding the terminal hepatic venule (zone III) in the rat liver acinus. Male SD rats were assigned to a resting group (n=8) and to running groups ran on a motor-driven treadmill for 100 min (n = 8) or did continued running beyond 100 min until exhaustion (n = 5) . Plasma guanase activity was increased with duration time of exercise. The arterial ketone body rate (AKBR) increased during the 100 min of running, but the AKBR significantly diminished with exhaustive running as compared with that for 100 min of running. Although there was no change in the mitochondrial structure of hepatocytes in the perportal area (zone I) during exhaustion, remarkable swelling was observed in that in zone III.<BR>These results suggest that acute running affects mitochondrial structures in zone III, and that this might be a hypoxia zone during exercise.

The Effect of Cryotherapy and Laser Photocoagulation for the Retinopathy of Prematurity

It has been generally accepted that cryotherapy is a effective therapy in structural outcome in management of threshold retinopathy of prematurity. Despited of this structural success, several potential complications have been termed ocular damage. The purpose of this study is to determine whether diode laser photocoagulation, which has fewer adverse effect and is easier to administe, is as effective as cryotherapy in treatment of prethreshold and threshold retinophthy of prematurity. Twenty-one eyes received diode laser retinal photocoagulation, ranging from 1090 to 1750 g birth weight, and sixty-two eyes received cryotherapy, from 1000 to 1680 g birth weight. The laser-treated eyes had 14.3% unfavorable outcome, and the eyes threated with cryotherapy is as effective as cryotherapy in the result suggests that diode laser therapy is as effective as cryotherapy in the treatment of prethreshold and threshold retinopathy of prematurity. Our study, however, showed that posterior retinopathy of prematurity in zone I was more aggressive than retinopathy of prematurity in zone II and had 42% unfavorable outcome. This result suggests that posterior retinopathy of prematurity requires a careful follow-up examination and and earlier surgical intervention than threshold retinopathy of prematurity.