The Correlation between Plasma Leptin Concentration and Adiposity in Obesity

BACKGROUND: Obesity can be considered as hyperaccumulation of body fat. Therefore, the aim to treat obesity is to decrease body fat. Abdominal total fat calculated in computed tomography is thought to be the most accurate index measuring body fat. The body mass index (BMI) and body fat mass are the representative indices also. Leptin is a protein hormone expressed by obesity gene in adipose tissue. It inhibits food intake and increases energy consumption, thereby controls obesity. With a study of relationship between plasma leptin level and body mass index and abdominal total fat area, we tried to find the usefulness of leptin as an index of adiposity. METHODS: The adiposity level was approximated by BMI, computed tomography and bioelectical impedence. To further explore the relationship with body composition, body fat distribution was determined by computed tomograph. To quantify the relationship between serum leptin level and adiposity, correlation analyses have been conducted. RESULTS: The subjects were 32 females with a BMI of over 25 kg/m2. The mean plasma leptin level was 14.2 5.9 ug/L. We investigated the correlation of plasma leptin level with subcutaneous and visceral fat. The plasma leptin level showed a significant correlation with BMI and body fat mass, and was significantly correlated with subctaneous fat (P<0.01), but not with abdominal visceral fat. CONCLUSION: A significant correlation between plasma leptin level and body fat mass was observed. The distribution of subcutaneous fat showed differences in plasma leptin level. Therefore, the plasma leptin level may be used as an index of change of body fat mass, especially subcutaneous fat.

The Effects of Vibration Baths on Abdominal Fat and Blood Lipid Profile in Obese Women

BACKGROUND: Abdominal obesity is recognized as an important risk factor of metabolic diseases and atherosclerosis. The purpose of this study was to investigate the effects of vibration baths on abdominal fat and blood lipid profiles in obese women. METHODS: From Apr. to Jun 2000, the 32 obese women received vibration baths for 4 weeks (30 minutes/day, repeated 5 times per week). The people were divided randomly into two groups, the case (n=17) and the control (n=15) group. The case group received vibration baths (55 Hz) and the control group took baths only. Body weight, height, body mass index (BMI), body fat distribution, lipid profiles, and blood pressures were measured in all subjects immediately before and after 4 weeks of the study. The body fat distribution was assessed by CT scan by which both total abdominal and visceral fat areas were measured at the level of the umbilicus. RESULTS: After 4 weeks, 13 subjects remained in both groups, respectively, and the total abdominal and visceral fat area decreased significantly in the case group compared from those of the control group. There were no significant differences in body weight, body fat mass, serum lipid profiles, and blood pressures before and after the baths in the two groups. CONCLUSIONS: These results suggest that vibration baths is effective in decreasing abdominal fat. But there were no significant weight change, the effect is insufficient in obesity treatment goal.