The Use of Eradacil(Rosoxacin) in Acute Gonococcal Urethritis / 대한비뇨기과학회지

From July 1982,30 male outpatients with acute gonococcal urethritis, bacteriologically confirmed to be positive for gonococci, were entered in this study. New bactericidal agent Eradacil was administered orally in a signal dose of 300mg in 30 case of acute gonococcal urethritis and following results were obtained. 1. All cases of acute gonococcal urethritis were cured. 2. In 4 cases, there was recurrence of urethral signs and symptoms 3 to 10 days after initial clearing following Eradacil therapy. These 4 case were retreated successfully with Doxycycline. 3. No serious side effects were observed except slight dizziness in one case.

Clinical Effect of Rosoxacin on Acute Gonococcal Urethritis / 대한비뇨기과학회지

Fourty gonococcal urethritis patients were treated with Rosoxacin at the Department of Urology, National Police Hospital from December, 1982 to April, 1983. All patients were male and confirmed as acute gonococcal urethritis by Gram stain and culture. A new bactericidal agent, Rosoxacin, was administered orally in a single dose of 300mg in 40 cases of acute gonococcal urethritis and following results were obtained. 1. Gram negative intracellular diplococci were controlled in 30 patients (100%) among 30 patients with pure gonococcal infection with a single oral dose of Rosoxacin. 2. 7 patients (23.3%) of 30 patients with pure gonococcal infection were revealed to nonspecific urethritis, and they were treated with other antibiotics. 3. Gram negative intracellular diplococci were controlled in 10 patients (100%) among 10 mixed infected patients with a single dose of Rosoxacin. 4. 8 patients (80%) of 10 patients with mixed infection were revealed to nonspecific urethritis, and they were treated with other antibiotics. 5. There was no side effect of Rosoxacin in all patients.

Doxytycline in Treatment of Acute Gonococcal Uriethritis / 대한비뇨기과학회지

This series represents 128 cases of acute gonococcal urethritis treated with doxycycline at the Seoul Red Cross Hospital from the 1st. May to.5th, Oct., 1969. Results of this treatment were divided in three groups: Group I ; Single dose of doxycycline, 300 mg. was administered for this group. 36 cases fall into this category. Cure rate for this group was 36%. Group II; Doxycycline, 200mg. was given on the 1st treatment day and daily dose of 100 mg. for 4 ensuing days. 42 cases were included to this group. Cure rate was 72%. Group III Daily dose of 200 mg. was administered for the remainders, 50 cases for 5 consecutive days. Cure rate was 91%. It was concluded that 200 mg. of doxycycline daily for 5 days dose regime can be recommended for the treatment of acute gonococcal urethritis, especially in cases allergic to penicillin or in which penicillin treatment fails. No anaphylactic shock or some other undesirable side reaction in administering this drug was experienced.