RESUMEN
The influences of the N -Isosuccinyl - dichloro - cinnamoylamide (7903) on the NA and 5 -HT systems in the brain were studied. Acute administration of 7903 could significantly enhance the level of NA and 5 -HT in mice brain and cortex of rats, and the level of 5 -HT in the hyporthalamus of rats was tending to be enhanced. However, chronic administration of 7903 (two weeks ) could decrease the level of NA and the ra-tio of 5-HIAA/5-HT in the cortex of rats; Chronic administration of 7903 could also decrease the turnover of NA and 5- HT in mice brain, but had no effects on the special binding of ? - receptor to 3-H - DHA and that of 5 -HT receptor to H - ketanserine in the cortex of rats.
RESUMEN
The antidepressant effects of the N-Isosuccinyl-dichlorocinnamo-ylamide ( 7903 ) , an analogue of piperine, upon 5 animal models were studied. The 7903 was found to have antidepressant effects on the models with doses less than TD50. The 7903 with the single dose, which did not increase the spontaneous motor activity of animals, could significantly decrease the duration of immobility of mice and rats in the forced-swimming test and that of mice in the tail-suspension test. The duration of the longest permanent immobility indaced by cornea electro-stimulation in mice was also decreased with the chronic administration ( 2 weeks ) of the 7903. And the hypothermia induced by reserpine could be antagonized by the 7903.