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Objective:To observe the effects of Jianweiyuyang(JWYY) pills on expressions of spasmolytic Polypeptide(SP)and intestinal trefoil factors(ITF) and analyze its potential mechanism. Methods:A Total of 76 gastric ulcer patients(final diagnosis by gastroscope),were randomly divided into two groups,JWYY treatment group,(36 cases,treatment group) and Ranitidine control group(36 samples,control group).Among them 50 Hp-positive PU patients were confirmed by gastroscope,histological inspection, and urease test,and showed the differentiation of symptoms and signs of the traditional Chinese medicine is the stagnation of liver-QI with deficiency of the spleen type for these 50 patients. There were 12 case in Normal groups.Detection on Biospy Specimens of gastric mucosa was done.The change of SP expression was detected by immunohischemicity,ITF by Western blotting and the contents of aninohexose and phosphatide in ulcerated gastric mucosa were measured. Results:The contents of aninohexose and phosphatide of PU patients increased in JWYY group and there was significant difference between JWYY group and Ranitidine group(P
RESUMEN
AIM:To observe the effect of Jianwei Yuyang Granule(Radix Bupleuri,Radix Codonopsis,Rhizoma Atractylodis macrocephalae,Rhizoma Corydalis,etc.) on the expressions of PS_2 and platelet activating factor(PAF) of helicobacterpylori-associated gastritis and study the potential mechanisim. METHODS:80 cases were divided into two groups.Jianwei Yuyang Granule group(42 cases) was given Jianwei Yuyang Granule and the control group(38 cases) was given three kinds of western medicines combined.H.pylori was detected by urease test on biopsy specimen of gastric mucosa and Warthin-Starry method and the changes of expressions of PS_2 and platelet activating factor(PAF) were observed.The contents of aninohexose and phosphatide in gastric mucosa were determined at the same time.All patients were rechecked gastroscope in the 6th week. RESULTS:The total effect rate of Jian-wei Yuyang group was higher than that of the control group(P
RESUMEN
AIM: To investigate the potencional mechanism of Sea Buckthorn Procyanidins(SBPC) against peptic ulcer. METHODS: 72 gastric ulcer patients(final diagnosis by gasroscope),were randomly divided into two groups,including Sea Buckthorn Procyanidins(SBPC) treatment group(36 cases),and Ranitidine control group(36 cases),among them,50 Hp-positive PU patients were confirmed by endoscopy,histological instection,urease test.Normal group was 12 cases.Detection on Biospy specimens of gastric mucosa was used to observe the change of ITF for Immunohischemical,PS_2 for western blotting and the contents of aninohexose and phosphatide in ulcerated gastric mucosa. RESULTS: The contents of aninohexose,phosphatide of PU patients increased in sea buckthorn procyanidins(SBPC) group.There was a linear correlation between the contents of phosphatide,aninohexose and the expression of ITF、PS_2 in PU patients(P