Research strategies and applications of functional metabolomics in anti-depressive mechanisms of traditional Chinese medicine / 药学学报

Depression is a common emotional disorder that seriously affects people's life and health all over the world. The pathogenesis of depression is complex, and traditional Chinese medicine (TCM) for antidepressants has a good therapeutic effect because of its multi-component, multi-pathway, and multi-target action mode. At present, the anti-depressive mechanism of TCM has not been fully clarified, but it is clear that depression is closely related to metabolic health. Therefore, in order to further explore the anti-depressive mechanism of TCM, this paper proposes research strategies on the anti-depressive mechanism of TCM based on functional metabolomics from the perspective of metabolism, the potential biomarkers of depression are analyzed with the help of multi-omics combined analysis technology, and the functional molecules of TCM for antidepressant are studied. Molecular biology techniques are used to accurately capture the molecular interactions between biomarkers of depression and functional compounds, which identify effective drug targets and further elucidate the biochemical functions and related mechanisms involved in depression metabolic disorders. This paper systematically reviews the research strategies and applications of functional metabolomics in the anti-depressive mechanisms of TCM, expounds on the core value of functional metabolomics, and summarizes the current research status and hot issues of TCM for antidepressants in recent years, providing new methods and new ideas for the study of mechanisms of TCM with the help of functional metabolomics.

Contribuição a uma teoria psicanalítica da mentira / Contribution to a psychoanalytic theory of the lie / Contribución a una teoría psicoanalítica de la mentira

A mentira, aspecto pouco edificante do psiquismo e tremendo obstáculo ao tratamento, também é, simultaneamente, uma capacidade psicológica à procura de um pensador. Um refúgio da mente. Uma função mental com um gradiente. Um elemento de vitalidade psíquica (Ogden). Uma possível conquista da análise

Lies, little edifying aspect of psychism and immense obstacle to treatment, is at the same time a psychological capacity in search of a thinker. A refuge of the mind. A mental function with a gradient. An element of psychic vitality (Ogden). A possible achievement of the analysis

La mentira, un aspecto poco edificante del psiquismo y un obstáculo formidable para el tratamiento, es también al mismo tiempo una capacidad psicológica en busca de un pensador. Un refugio de la mente. Una función mental con un gradiente. Un elemento de vitalidad psíquica (Ogden). Una posible conquista del análisis

La depresión: encrucijada entre las nuevas modalidades del ser y el dispositivo farmacéutico / Depression: crossroads between the new modalities of the being and the pharmaceutical apparatus

Siguiendo la tesis del sociólogo Alain Ehrenberg, la depresión se instaló en las sociedades occidentales como una consecuencia de las nuevas modalidades del individuo. La emancipación y la soberanía individual comenzadas en el siglo de las luces trajeron consigo nuevos malestares de la mente. La neurastenia resume la primera "epidemia" mundial que muestra las consecuencias de estas mutaciones antropológicas. La neurosis y el psicoanálisis demuestran que la depresión y otras formas de sufrimiento de las personas ordinarias son el resultado de un precio a pagar por entrar en la civilización. Para Ehrenberg, la epidemia contemporánea de depresión es el rostro de un eclipse de la culpabilidad y el conflicto interior, favoreciendo una apertura de infinitas posibilidades y la consagración personal como nuevos ideales constitutivos de la personalidad y la identidad, siendo la depresión una disfunción o insuficiencia a convertirse en uno mismo. Sin embargo, las tesis de Ehrenberg no toman en cuenta el esfuerzo realizado por la industria farmacéutica y el dispositivo comercial y de mercadeo creado para modificar las costumbres y el saber médico, facilitando así la explosión diagnóstica y autodiagnóstica de este trastorno controversial.

Based on the thesis of the sociologist Alain Ehrenberg depression settled in Western societies as a result of the consequences of the new types of individuals. The emancipation and sovereignty from the beginning of the Century of Light brought new mind ailments. Neurasthenia is the first "epidemic" as a result of these anthropological mutations. Neurosis and psychoanalysis show that depression and other ailments in ordinary people are but the result of a price to pay when entering civilization. For Ehrenberg, depression which is the contemporary epidemic is the face of an eclipse between guilt and interior conflict, favoring an openness of infinite possibilities and the personal sacredness as new ideals which make the personality and the identity, depression is a dysfunction which does not allow one to become oneself. However, Ehrenberg ́s theses do not take into account the efforts of the pharmaceutical industry or the marketing strategies created to modify costumes, nor the medical knowledge, facilitating the explosion of the diagnosis and self diagnosis of this controversial illness.