RESUMEN
Objective To prepare berberine hydrochloric nanoemulsion and study its physicochemical characteristics of nanoemulsion.Methods The nanoemulsion components of isopropyl myristate(IPM),EL40,and glycerin were selected.Berberine hydrochloric nanoemulsion was prepared with pseudoternary phase diagrams.Taking centrifuge tests(13 000 r/min,30 min) and the average diameter as evaluation indexes of nanoemulsion,the content of berberine hydrochloric in nanoemulsion was determined through HPLC.The basic physicochemical characteristics including viscosity,electric conductivity,refraction,zeta-potentral,and particle diameter were studied.And also the stability of nanoemulsion was studied under the conditions of high humid(92.5%),high temperature(40 ℃ and 60 ℃),and strong light [(4 500?500) lx].Results Prepared nanoemulsion was a kind of clarity and transparent solution and it presented as small spherical drops under election microscopy,with the average diameter of about 56.8 nm.Its nanoemulsion for oral application was stable.And also their content and diameter had no distinct change under the above-mentioned conditions.Conclusion The berberine hydrochloric nanoemulsion is good drug delivery system with quality stability.