RESUMEN
Objective To discuss the correlation between the joint detection of BA,EMAb,ACA and unexplained recurrent spontaneous abortion(URSA).Methods Selected 144 URSA cases,166 SA(sporadic abortion)cases,188 normal pregnant women,and detected their BA,EMAb,ACA and statistical analysis of parallelism.Results Comparing URSA group with SA group and control group respectively,there were significant statistical difference between BA negative rate (74.31%, 25.30% and 50.53%),EMAb positive rate (35.42%,7.23% and 6.91%)and ACA positive rate (26.39%,5.42% and 5.32%)(χ2 = 19.344 ~ 74.180;P < 0.05;χ2 = 37.837 ~ 42.586,P < 0.05),(χ2 = 26.355 ~ 29.270,P < 0.05).URSA group’s BA,ACA and EMAb joint detection rate of positive (84.72%)was significantly higher than SA group and the con-trol group (χ2 =35.532~93.076,P <0.05).Conclusion There was a close relationship between the lack of BA,the genera-tion of EMAb,ACA and unexplained recurrent spontaneous abortion.Joint detection has important clinical significance in auxiliary diagnosis of unexplained recurrent spontaneous abortion and prognosis judgement.
RESUMEN
Recurent spontaneous abortion (RSA) was classified into the primary (1?) and the sec-ondary (2?) according to patients histoty.Occurence of blocking antibodies between them wasinvestigated with mixed lymphocyte reaction—blocking assay and complement dependent cyto-toxicity assay.It was found that the primary abortion had been mainly caused by lack of block-ing antibodies,the secondary abortion without lack of blocking antibodies.Thus,the primaryabortion is different from the secondary abortion in aspects of immune aetiology and immunemechanisms although their clinical manifestations are similar.