Clinical analysis of 16 cases of irritable bowel syndrome of gastrointestinal motility function / 中国医学装备

Objective:To analyze irritable bowel syndrome of 16 cases of gastrointestinal motor function, and provide a theoretical basis for the clinical study on the pathogenesis of irritable bowel syndrome and clinical drug treatment. Methods: Patients in our hospital from 2009 to 2011 with irritable bowel syndrome of esophageal pH monitoring, gastric electrical detection and breath hydrogen test was performed in 16 patients. Results: the patients with irritable bowel syndrome before and after meal gastric electrical change significantly compared with the control group(t=-8.437, t=-7.126;P<0.01), gastric electrical variability index, intestinal transfer time and the control group with significant difference (t=-2.312, t=-1.694, t=-9.163, t=-7.894;P<0.01). Conclusion:The abnormal in patients with irritable bowel syndrome and intestinal digestion and absorption function may be caused by abnormal gut electrophysiological activity.

Lactose tolerance and intolerance in Malaysians

This review explores the digestibility of lactose by Malaysians, and the value of milk and other milk-derived products as sources of appropriate nutrition for Malaysians. Increased calcium intake through consumption of milk is an effective mechanism for increasing calcium uptake from the diet and thereby minimising the risk of development of osteoporosis in later life. Detailed information about rates of lactose intolerance, and adaptation to dietary lactose and its consequences for Malaysians, will help in the formulation of dietary advice, and improve commerial food manufaturing practice and Government policy directed to the minimization of rates of osteoporosis, which presents a substantial morbidity risk to elderly female Asians in particular.

Influence of Azithromycin on Breath Hydrogen Test in Acute Upper Respiratory Infection in Children / 实用儿科临床杂志

Objective To evaluate influence of Azithromycin on breath hydrogen test(BHT) in acute upper respiratory infection(AURI) in Children.Methods Fasting BHT and lacunose BHT were respectively performed by using HD-1 breath hydrogen detector for 38 inpatients before and after receiving Azithromycin.Fasting BHT of 115 healthy controls were determined.Results After Azithromycin was given,Fasting BHT was lower than that before Azithromycin used(P

Lactulose Breath Hydrogen Test in Diagnosis of Small Intestinal Bacterial Overgrowth in Children / 实用儿科临床杂志

Objective To evaluate lactulose breath hydrogen test in diagnosis of small intestinal bacterial overgrowth in children.Me-thods Thirty-five children,aged 3 to 13 years old with mean (7.72?3.06) years old presented with chronic diarrhea,abdominal pain and flatulence.Among them,18 cases were male and 17 cases were female.Breath hydrogen test was carried out after the administration of a 0.5 g?kg-1 or 10 g lactulose,which was 100 g?L-1 solution.After the ingestion of lactulose,the breath hydrogen was collected in every 20 minutes and up to 3 hours.Small intestinal bacterial overgrowth was diagnosed as positive when the hydrogen concentration increased more than 20 mg?m-3 in a sample.Results Eighteen cases in 35 (51.43%) children were positive and 17 cases were negative.Among these positive cases,8 cases in 18 (22.86%) patients were typically double peaks in breath hydrogen concentrations.Among the causes of small intestinal bacterial overgrowth in children,4 cases with chronic superficial gastritis,4 cases with chronic bacterial enteritis,2 cases with malnutrition and anorexia,1 case with volvulus of stomach,1 case with massive resection of small intestine,1 case with steatorrhea and 5 cases with unknown causes.Four cases of chronic bacterial enteritis were gained remission by antimicrobial agents.The other cases were treated by lac-to-and bifidbacteria probiotics.Seven patients of the clinical systems were controlled,3 cases were improved remarkably and 4 cases were failed.Conclusions The lactulose breath hydrogen test is validated as screening test in the diagnosis of small intestinal bacterial overgrowth in children.Antimicrobial agents and bifidbacteria probiotics is effective in treatment of small intestinal bacterial overgrowth.

Prevalence of Lactose Malabsorption in Children by Breath Hydrogen Test / 대한소아소화기영양학회지

PURPOSE: The aim of this study was to investigate the age of onset and the prevalence of lactose malabsorption in early childhood in Korea. METHODS: We conducted a study of lactose malabsorption by breath hydrogen test in healthy children aged between 25~96 months old. Standard lactose loading (2 g lactose/kg, maximum 40g) test was done in 129 children and cow's milk (10 mL/kg) loading in 126 children followed by breath sampling of 60 and 120 minutes after the loading. An increase above baseline of 20 ppm or more was used as a criteria for positive responses. RESULTS: The prevalence of lactose malabsorption was 7% in 25~36 months old, 19% in 37~48 months old, 35% in 49~60 months old, 55% in 61~72 months old, 82% in 72~84 months old, 80% in 85~96 months old children. Only 1% of the children showed positive result in breath hydrogen test after the cow's milk challenge. CONCLUSION: The prevalence of lactose malabsorption was increased between 37 months and 60 months of age, reached to adult level of prevalence after 72 months of age. When physiological dose of lactose was used as the challenge, the number of lactose malabsorbers become clinically insignificant.

AN INVESTIGATION OF THE ABSORPTION AND INTOLERANCE OF LACTOSE IN MILK AND YOGURT IN NORMAL ADULTS / 营养学报

For investigation on the lactose absorption and tolerance in milk and yogurt, 30 healthy adults were tested by a non-invasive and sensitive hydrogen breath test after drinking half a pound of each daily separately. The results showed that 4 persons absorbed the lactose in the milk completely (13.3%), but 26 showed malabsorption (86.7%), among them, 1 case was slight malabsorption (3.3%), 16 moderate (53.3%) and 9 severe in degree (30%). The intolerance rate and intolerance index of lactose in milk were 53.3% and 0.9; but 6.7% and 0.067 in yogurt respectively.The milk lactose intolerant person expired more hydrogen as 60.34?30.57 ml, while drinking yogurt the hydrogen dropped to 14.97 ?33.64ml (P