RESUMEN
Subepidermal calcified nodule is a rare form of calcinosis cutis, which is not associated with any dermatologic or systemic diseases, and usually presents as a solitary hard nodule on the face or neck of children. A 25-month-old boy had a small pea-sized, tender nodule on his left sole that had been present for several months. There was no history of previous trauma or systemic illness. The clinical diagnosis as a viral wart was initially made and treated with cryotherapy. Because the lesion was not clear and a yellow-white firm papule was seen after cryotherapy, punch excision was done. Histologic examination showed cystic structure with calcium deposition in the upper dermis. Herein, we present the findings of a patient with a rare, solitary subepidermal calcified nodule on the sole.
Asunto(s)
Niño , Preescolar , Humanos , Masculino , Calcinosis , Calcio , Crioterapia , Dermis , Diagnóstico , Cuello , VerrugasRESUMEN
Subepidermal calcified nodule is an unusual type of idiopathic calcinosis cutis and usually presents as an asymptomatic, solitary, firm, verrucous, white or yellowish nodule. It commonly occurs in young children, generally on the face and neck, especially eyelid, cheek. However, sole is a very rare site. Four patients presented with several months??history of solitary 2~3 mm sized firm nodule on the sole. Three of the patients were less than 1 year old, with no history of trauma. Histopathologic examination revealed hyperkeratosis, acanthosis and amorphous basophilic material in cystic space beneath the epidermis, meaning deposition of calcium salt. These histopathologic features were consistent with subepidermal calcified nodule. Serum calcium and phosphorus levels of the patients were within normal limits. Herein, we present 4 cases of subepidermal calcified nodule on the sole, an atypical location.
Asunto(s)
Niño , Humanos , Basófilos , Calcinosis , Calcio , Mejilla , Epidermis , Párpados , Cuello , FósforoRESUMEN
Luteolin is a flavonoid that exists in a glycosylated form in celery and green pepper. Flavonoids possess antioxidant and anti-inflammatory properties and can reduce the expression of key inflammatory molecules in macrophages and monocytes. It has been reported also that some flavonoids have effects on bone metabolism. The effects of luteolin on the function of osteoblasts were investigated by measuring cell viability, alkaline phosphatase activity, type I collagen production, osteoprotegerin secretion, Wnt promoter activity, BMP-2 and Runx2 expression and calcified nodule formation. Luteolin has no effects upon osteoblast viability but induced an increase in alkaline phosphatase activity, type I collagen production and a decrease in osteoprotegerin secretion in these cells. Luteolin treatment also upregulated BMP-2 mRNA expression. These results suggest that luteolin may be a regulatory molecule that facilitates the differentiation of osteoblasts.
Asunto(s)
Fosfatasa Alcalina , Apium , Capsicum , Supervivencia Celular , Colágeno Tipo I , Flavonoides , Luteolina , Macrófagos , Monocitos , Osteoblastos , Osteoprotegerina , ARN MensajeroRESUMEN
Subepidermal calcified nodule is a rather uncommon, but peculiar subtype of calcinosis cutis. It presents as a single asymptomatic, hard, yellowish white nodule which commonly occurs on the face of children. Histopathologic examination reveals the multifocal various-sized papillary dermal collection of dark blue amorphous globular deposits confirmed by von Kossa stain for calcium. We report a 42-year-old man who had small white hyperkeratotic papule on finger tip for more than 20 years. He could recall neither preceding trauma nor systemic illness. Excisional biopsy, with the clinical impression of verruca or corn, showed typical histopathologic features of the subepidermal calcified nodule.
Asunto(s)
Adulto , Niño , Humanos , Biopsia , Calcinosis , Calcio , Dedos , Verrugas , Zea maysRESUMEN
Subepidermal calcified nodule, a subset of calcinosis cutis, is usually presented as single small, raised, hard nodule. Histologically calcium deposition can be detected by von Kossa or periodic acid-Schiff stain. We report a 3-year-old boy who had erythematous hyperkeratotic plaques and papules on both inner thighs without any previous history of trauma, genetic or systemic illness. A biopsy specimen of plaque of the thigh showed the transepidermal elimination of basophilic granules which were dispersed in the upper dermis and von Kossa stain revealed scattered calcific deposition.
Asunto(s)
Preescolar , Humanos , Masculino , Basófilos , Biopsia , Calcinosis , Calcio , Dermis , MusloRESUMEN
Calcified nodules on the heel have been observed in low-birth weight neonates subjected to repeated heel pricks in intensive care units. Calcified nodules appear at 4 to 12 months of age and disappear spontaneously at 18 to 30months. We report a 12-month-old girl with calcified nodule on the heel. There were no clinical signs of inflammation and tenderness. The patient was born at the 31st week of pregnancy and spent 6 weeks in a neonatal intensive care unit. Histopathologic examination revealed a deposition of calcium material.
Asunto(s)
Niño , Femenino , Humanos , Lactante , Recién Nacido , Embarazo , Calcio , Talón , Inflamación , Unidades de Cuidados Intensivos , Cuidado Intensivo NeonatalRESUMEN
The subepidermal calcified nodule, also known as a form of calcinosis cutis, is characterized by solitary circumscribed deposits of insoluble calcium within the subepidermis. The disease is not associated with any systemic or cutaneous diseases, or any biochemical abnormalities. The pathogenesis is still unknown. A 55-year-old female presented with a 4-month history of solitary skin-colored, hyperkeratotic papule on the left upper eyelid. The lesion was asymptomatic and had increased slowly in size. It is interesting that excisional biopsy showed typical histopathologic features of the subepidermal calcified nodule and the clear cell syringoma.
Asunto(s)
Femenino , Humanos , Persona de Mediana Edad , Biopsia , Calcinosis , Calcio , Párpados , SiringomaRESUMEN
Subepidermal calcified nodule, a form of idiopathic calcinosis cutis, typically present as a hard, 3 to 11 mm, solitary lesion on the exposed area of the head and the extremities. Here we re-port an unusual case of subepidermal calcified nodule occurring on the buttock. A 15-year-old girl presented with a 6-month history of a 12 × 6 mm, oval, hard, erythematous nodule on the right buttock. Histopathologic examination of an excision biopsy specimen revealed extensive deposition of calcium in the whole dermis as large multilobulated masses.
Asunto(s)
Adolescente , Femenino , Humanos , Biopsia , Nalgas , Calcinosis , Calcio , Dermis , Extremidades , CabezaRESUMEN
Subepidermal calcified nodule(SCN) is a form of calcinosis cutis which is usually present as a single small, raised, hard nodule with verrucous surface. A 13-year-old girl presented with a 10-month history of a ricegrain-sized, hard, yellowish white papule on both upper eyelids. The lesions were asymptomatic and had increased slowly in size. An excisional biopsy specimen of the left upper eyelid showed acanthosis and narrow pointed rete ridges of the epidermis, and closely aggregated deposition of basophilic material in the uppermost dermis. The material in the dermis did not stain with von Kossa. It was confirmed as calcium deposition by staining with alizarin red S which is far more specific for calcium than the von Kossa stain.
Asunto(s)
Adolescente , Femenino , Humanos , Basófilos , Biopsia , Calcinosis , Calcio , Dermis , Epidermis , PárpadosRESUMEN
Subepidermal calcified nodule, a form of calcinosis cutis, usually occurs as a solitary lesion and develops in early childhood. We report a 20-month-old boy with an unusual form of subepidermal calcified nodules on both palms and soles which were multiple and present at birth. Interestingly, his uncle had similar lesions during infancy which had shown spontaneous remission.