RESUMEN
The expression of transforming growth factor-β1 (TGF-β1) in placental tissue of pregnancy-induced hypertension (PIH) and the relationship between the level of expression of TGF-β1 and the amount of vascular cell adhesion molecule-1 (VCAM-1) in serum was studied. Immunohistochemistry ABC was used to detect the expression and distribution of TGF-β1 in placental tissues in 40 PIH women and 20 normal pregnancy women. High resolution pathological image analysis system was used to determine the quality of TGF-β1. The VCAM-1 in serum was examined by enzyme linked immunoabsorbent assay (ELISA). The results showed that TGF-β1 could be express in syncytiotrophoblast. The levels of TGF-β1 expression in placental tissues of the patients with moderate and severe PIH were significantly higher (P＜0.05), while the serum VCAM-1 was significantly lower than in normal group (P＜0.01). There was a significant positive correlation between the expression of TGF-β1 in placental tissues and the serum VCAM-1 (r=0. 969, P＜0.01). It was concluded that the level of TGF-β1 expression in PIH was increased and was positively correlated with the amount of serum VCAM-1, indicating that they might be involved in the pathogenesis of PIH.
RESUMEN
AIM: To explore the serum levels of certain adhesion mole cules and its significance in acute coronary syndrome(ACS). METHODS: The subjects included 40 patients with acute myocardial infarction(AMI) and 40 patients with unstable angina pectoris (UAP). Among the 80 patients, 60 patients accepted a follow- up 4 months. At the same time we selected 40 controls from people who atte nded a routine health check in the university. Serum levels of E-selectin,sICAM -1,sVCAM-1 were measured by ELISA. RESULTS: Serum level s of E-selectin ,sICAM-1,sVCAM-1 were significantly higher in the ACS group(AMI or UAP) than in the control group. Four months later, the levels of E-selectin,sICAM-1 bec ame sig nificantly lower in the follow-up group than in the ACS group, while sVCAM- 1 showed no significant difference. CONCLUSION: Serum levels of E-se lectin ,sICAM-1 may have certain diagnostic value for ACS, and can be a useful marker reflecting th e stability of the disease.